Enhanced fibrotic potential of COL1A1hiNR4A1low fibroblasts in ischemic heart revealed by transcriptional dynamics heterogeneity analysis at both bulk and single-cell levels

BackgroundFibroblasts in the fibrotic heart exhibit a heterogeneous biological behavior. The specific subsets of fibroblasts that contribute to progressive cardiac fibrosis remain unrevealed. Our aim is to identify the heart fibroblast (FB) subsets that most significantly promote fibrosis and the re...

Full description

Bibliographic Details
Published in:	Frontiers in Cardiovascular Medicine
Main Authors:	Cheng Luo, Baoping Tan, Luoxiang Chu, Liqiang Chen, Xinglong Zhong, Yangyang Jiang, Yuluan Yan, Fanrui Mo, Hong Wang, Fan Yang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Subjects:	fibroblasts ischemic heart disease cardiac fibrosis single nuclei RNA sequencing diagnostic model
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2024.1460813/full

Similar Items

Mid-infrared Properties of Narrow-line Seyfert 1 Galaxies Detected by LoTSS DR2
by: Xu-Liang Fan
Published: (2024-01-01)

On the Properties of X-Ray Corona in Seyfert 1 Galaxies
by: Indrani Pal, et al.
Published: (2024-01-01)

X-Ray Unveiling Events in a z ≈ 1.6 Active Galactic Nucleus in the 7 Ms Chandra Deep Field-South
by: Li-Ming Yu, et al.
Published: (2023-01-01)

Advancements in nuclear physics research using Beijing HI-13 tandem accelerator
by: HUA Hui, et al.
Published: (2023-08-01)

A UV to X-Ray View of Soft Excess in Type 1 Active Galactic Nuclei. I. Sample Selection and Spectral Profile
by: Shi-Jiang Chen, et al.
Published: (2025-01-01)

Keep it accurate and robust: An enhanced nuclei analysis framework
by: Wenhua Zhang, et al.
Published: (2024-12-01)

The Pan-STARRS1 z > 5.6 Quasar Survey. II. Discovery of 55 Quasars at 5.6 < z < 6.5
by: Eduardo Bañados, et al.
Published: (2023-01-01)

A Reemerging Bright Soft X-Ray State of the Changing-look Active Galactic Nucleus 1ES 1927+654: A Multiwavelength View
by: Ritesh Ghosh, et al.
Published: (2023-01-01)

Late-time Radio Brightening and Emergence of a Radio Jet in the Changing-look AGN 1ES 1927+654
by: Eileen T. Meyer, et al.
Published: (2025-01-01)

Strong X-Ray Variability of I Zwicky 1: Obscuration from Clumpy Accretion-disk Winds
by: Jian Huang, et al.
Published: (2026-01-01)

X-Ray Polarization Variability of High Spectral Peak BL Lacertaes: Cases of 1ES 1959+650 and PKS 2155–304
by: Xin-Ke Hu, et al.
Published: (2024-01-01)

SDSS J110546.07+145202.4: The First Long-duration Radio Changing-look NLS1 Galaxy
by: S. Komossa, et al.
Published: (2026-01-01)

A Complete 16 μm Selected Galaxy Sample at z ∼ 1. II. Morphological Analysis
by: Piaoran Liang, et al.
Published: (2024-01-01)

Progress on the Relationship Between the Regulation of Gastrointestinal System Function by Acupuncture and Central Nuclei
by: BU Fan-you, et al.
Published: (2017-01-01)

The Origin Channels of Hierarchical Binary Black Hole Mergers in the LIGO–Virgo–KAGRA O1, O2, and O3 Runs
by: Guo-Peng Li, et al.
Published: (2025-01-01)

lnc-SAMD14-4 can regulate expression of the COL1A1 and COL1A2 in human chondrocytes
by: Haibin Zhang, et al.
Published: (2019-09-01)

The Messy Nature of Fiber Spectra: Star–Quasar Pairs Masquerading as Dual Type 1 AGNs
by: Ryan W. Pfeifle, et al.
Published: (2023-01-01)

Identification of 4FGL Uncertain Sources at Higher Resolutions with Inverse Discrete Wavelet Transform
by: Haitao Cao, et al.
Published: (2024-01-01)

A Search for X-Ray/UV Correlation in the Reflection-dominated Seyfert 1 Galaxy Markarian 1044
by: Samuzal Barua, et al.
Published: (2023-01-01)

A Disk-originated 329 Day Quasiperiodic Oscillation in the Seyfert 1 Galaxy J1626+5120
by: Litao Zhu, et al.
Published: (2025-01-01)

Discovery of Giant Radio Sources from TGSS Alternative Data Release 1: Radio, Optical, and Infrared Properties
by: Netai Bhukta, et al.
Published: (2024-01-01)

AT2021aeuk: A Repeating Partial Tidal Disruption Event Candidate in a Narrow-line Seyfert 1 Galaxy
by: Jingbo Sun, et al.
Published: (2025-01-01)

Detection of X-Ray Polarization from the Blazar 1ES 1959+650 with the Imaging X-Ray Polarimetry Explorer
by: Manel Errando, et al.
Published: (2024-01-01)

The evaluation of variants within eight collagen genes COL1A1, COL1A2, COL3A1, COL5A1, COL11A1, COL15A1, COL22A1, and COL27A1 and a risk of non-contact knee ligament rupture in elite handball players: A case-control study
by: Katarzyna KRAWCZAK-WÓJCIK, et al.
Published: (2025-09-01)

A Two-zone Accretion Disk in the Changing-look Active Galactic Nucleus 1ES 1927+654: Physical Implications for Tidal Disruption Events and Super-Eddington Accretion
by: Ruancun Li, et al.
Published: (2024-01-01)

Barriers in the energy of deformed nuclei
by: V. Yu. Denisov, et al.
Published: (2014-06-01)

Testing Physical Scenarios for the Reflection Features of Type-1 AGNs using XMM-Newton and NuSTAR Simultaneous Observations
by: César Ivan Victoria-Ceballos, et al.
Published: (2023-01-01)

XMM-Newton Observations of Two Archival X-Ray Weak Type 1 Quasars: Obscuration Induced X-Ray Weakness and Variability
by: Zijian Zhang, et al.
Published: (2023-01-01)

A Radio Changing-state Jet in the Narrow-line Seyfert 1 Galaxy J1105+1452
by: Liming Dou, et al.
Published: (2026-01-01)

Dust-obscured Galaxies in the XMM-SERVS Fields: Selection, Multiwavelength Characterization, and Physical Nature
by: Zhibo Yu, et al.
Published: (2024-01-01)

Charge density distributions for odd-A of 2s-1d shell nuclei
by: Baghdad Science Journal
Published: (2010-06-01)

Novel variations in the PLOD1, COL1A1, COL5A2 and COL4A1 genes related to keratoconus
by: Qinghong Lin, et al.
Published: (2025-03-01)

Therapeutic potential for targeting Annexin A1 in fibrotic diseases
by: Zhibin Yan, et al.
Published: (2022-11-01)

FORMATION AND REARING OF THE BEE NUCLEI (Apis mellifera L.)
by: Zlatko Puškadija, et al.
Published: (2008-12-01)

Ectopic Expansion of Pulmonary Vasculature in Fibrotic Lung Disease and Lung Adenocarcinoma Marked by Proangiogenic COL15A1+ Endothelial Cells
by: Eric Engelbrecht, et al.
Published: (2025-04-01)

On the Extremely X-Ray Variable Active Galactic Nuclei in the XMM-LSS Field
by: Zijian Zhang, et al.
Published: (2025-01-01)

The ratio of COL2A1:COL1A1 in dartos tissue patients with hypospadias
by: Prahara Yuri, et al.
Published: (2025-01-01)

Tumor-Infiltrating PD-1hiCD8+-T-Cell Signature as an Effective Biomarker for Immune Checkpoint Inhibitor Therapy Response Across Multiple Cancers
by: Zhenyu Yang, et al.
Published: (2021-09-01)

The Hα Broadband Photometric Reverberation Mapping of Four Seyfert 1 Galaxies
by: Qinchun Ma, et al.
Published: (2023-01-01)

Investigation of Stellar Kinematics and Ionized Gas Outflows in Local (U)LIRGs
by: Ashraf Ayubinia, et al.
Published: (2023-01-01)