| الملخص: | <p><strong>Objective</strong> To evaluate the value of multimodal molecular imaging in the diagnosis of dementia with Lewy bodies (DLB). <strong>Methods</strong> Five patients with probable DLB received detailed clinical data collection, neuropsychological tests, head MRI examination, <sup>11</sup>C-methyl-N-2β-carbomethoxy-3β-(4-fluorophenyl)-tropane (<sup>11</sup>C-β-CFT) PET, <sup>11</sup>C-Pittsburgh compound B (<sup>11</sup>C-PIB) PET and <sup>18</sup>F-fluoro-2-deoxy-D-glucose (<sup>18</sup>F-FDG) PET examination. <strong>Results</strong> Cognitive dysfunction and visual hallucinations were prominent symptoms in patients with DLB. <sup>11</sup>C-β-CFT PET showed that the radioactive uptake significantly reduced in bilateral putamen and caudate nuclei. <sup>11</sup>C-PIB PET showed increased radioactive retention in bilateral frontal, temporal, parietal and occipital cortex with various degrees. <sup>18</sup>F-FDG PET showed glucose hypometabolism in bilateral parietal and occipital cortex. <strong>Conclusions</strong> Multimodal molecular imaging greatly improves the specificity of clinical diagnosis of DLB, and it is expected to achieve accurate diagnosis before death.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2017.01.009</p>
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