The application of multimodal molecular imaging in the diagnosis of dementia with Lewy bodies

• Published in: Chinese Journal of Contemporary Neurology and Neurosurgery
• Main Authors: Zhong-bao GAO, Wei WANG, Tong CHEN, Li-ping FU, Bai-xuan XU, Zhen-fu WANG
• Format: Article
• Language: English
• Published: Tianjin Huanhu Hospital 2017-01-01
• Subjects: Lewy body disease; Dementia; Positron-emission tomography
• Online Access: http://www.cjcnn.org/index.php/cjcnn/article/view/1536

<p><strong>Objective</strong> To evaluate the value of multimodal molecular imaging in the diagnosis of dementia with Lewy bodies (DLB). <strong>Methods</strong> Five patients with probable DLB received detailed clinical data collection, neuropsychological tests, head MRI examination, ¹¹C-methyl-N-2β-carbomethoxy-3β-(4-fluorophenyl)-tropane (¹¹C-β-CFT) PET, ¹¹C-Pittsburgh compound B (¹¹C-PIB) PET and ¹⁸F-fluoro-2-deoxy-D-glucose (¹⁸F-FDG) PET examination. <strong>Results</strong> Cognitive dysfunction and visual hallucinations were prominent symptoms in patients with DLB. ¹¹C-β-CFT PET showed that the radioactive uptake significantly reduced in bilateral putamen and caudate nuclei. ¹¹C-PIB PET showed increased radioactive retention in bilateral frontal, temporal, parietal and occipital cortex with various degrees. ¹⁸F-FDG PET showed glucose hypometabolism in bilateral parietal and occipital cortex. <strong>Conclusions</strong> Multimodal molecular imaging greatly improves the specificity of clinical diagnosis of DLB, and it is expected to achieve accurate diagnosis before death.</p><p> </p><p><strong>DOI: </strong>10.3969/j.issn.1672-6731.2017.01.009</p>