Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues

ABSTRACT Herpesviruses are large double-stranded DNA viruses that encode core replication proteins and accessory factors involved in nucleotide metabolism and DNA repair. Mammalian uracil-DNA glycosylases (UNG) excise deleterious uracil residues from their genomic DNA. Each herpesvirus UNG studied t...

書誌詳細
出版年:	mSphere
主要な著者:	Kyle R. Smith, Somnath Paul, Qiwen Dong, Orchi Anannya, Darby G. Oldenburg, J. Craig Forrest, Kevin M. McBride, Laurie T. Krug
フォーマット:	論文
言語:	英語
出版事項:	American Society for Microbiology 2023-10-01
主題:	gammaherpesvirus lytic replication uracil-DNA glycosylase viral DNA polymerase viral DNA polymerase processivity factor viral replication compartment
オンライン･アクセス:	https://journals.asm.org/doi/10.1128/msphere.00278-23

類似資料

A New Class of Uracil–DNA Glycosylase Inhibitors Active against Human and Vaccinia Virus Enzyme
著者:: Inga R. Grin, 等
出版事項: (2021-11-01)

Single G-quadruplex-based fluorescence method for the uracil-DNA glycosylase inhibitor screening
著者:: Pansong Zhang, 等
出版事項: (2024-09-01)

A Multimodal Approach towards Genomic Identification of Protein Inhibitors of Uracil-DNA Glycosylase
著者:: Wael Muselmani, 等
出版事項: (2023-06-01)

Viral replication organelles: the highly complex and programmed replication machinery
著者:: Hao Deng, 等
出版事項: (2024-07-01)

Apolipoprotein E selectively supports gammaherpesvirus replication in macrophages
著者:: Damon L. Schmalzriedt, 等
出版事項: (2025-06-01)

Repair and DNA Polymerase Bypass of Clickable Pyrimidine Nucleotides
著者:: Anton V. Endutkin, 等
出版事項: (2024-06-01)

Mismatch uracil DNA glycosylase (Mug) is maintained in the Corynebacterium pseudotuberculosis genome and exhibits affinity for uracil but not other types of damage
著者:: Bruno Carvalho Resende, 等
出版事項: (2025-04-01)

Real-time PCR method for detection of short DNA using a deoxyuridine probe and application for detection of fomivirsen
著者:: Naoki Harikai, 等
出版事項: (2022-12-01)

An extension of the Beretta-Kuang model of viral diseases
著者:: Ivo Siekmann, 等
出版事項: (2008-05-01)

Colorimetric and electrochemical dual-signal detection of uracil-DNA glycosylase using functionalized pure DNA hydrogel on paper-based analytical devices
著者:: Wei Xue, 等
出版事項: (2023-09-01)

Anchored linear oligonucleotides: the effective tool for the real-time measurement of uracil DNA glycosylase activity
著者:: Anna Ligasová, 等
出版事項: (2021-10-01)

Editorial: The DNA Replication Machinery as Therapeutic Targets
著者:: Andrew F. Gardner, 等
出版事項: (2019-05-01)

Vaccination with a Replication-Dead Murine Gammaherpesvirus Lacking Viral Pathogenesis Genes Inhibits WT Virus Infection
著者:: Dipanwita Mitra, 等
出版事項: (2024-12-01)

Independent Inhibition of the Polymerase and Deubiquitinase Activities of the Crimean–Congo Hemorrhagic Fever Virus Full-Length L-Protein
著者:: Egor P. Tchesnokov, 等
出版事項: (2020-06-01)

Identifying Protein Interactions with Viral DNA Genomes during Virus Infection
著者:: Jessica E. Packard, 等
出版事項: (2024-05-01)

HDACi mediate UNG2 depletion, dysregulated genomic uracil and altered expression of oncoproteins and tumor suppressors in B- and T-cell lines
著者:: Tobias S. Iveland, 等
出版事項: (2020-04-01)

Dimethyl Sulfoxide Enhances Kaposi’s Sarcoma-Associated Herpesvirus Production During Lytic Replication
著者:: Su-Kyung Kang, 等
出版事項: (2021-12-01)

One-pot, uracil-DNA-glycosylase-aided, and multi-indicator nanobiosensor detection platform for identifying Brucella melitensis from the Brucella spp
著者:: Xinggui Yang, 等
出版事項: (2025-08-01)

Impact of metal oxide nanoparticles on in vitro DNA amplification
著者:: Chun-Hui Gao, 等
出版事項: (2019-06-01)

Structure of a DNA Glycosylase Bound to a Nicked T:G Mismatch-Containing DNA
著者:: Hala Ouzon-Shubeita, 等
出版事項: (2025-05-01)

The DNA polymerases of Drosophila melanogaster
著者:: Steven J. Marygold, 等
出版事項: (2020-10-01)

Guinea Pig X Virus Is a Gammaherpesvirus
著者:: Vy Ngoc Yen Truong, 等
出版事項: (2025-08-01)

Bisbenzimide compounds inhibit the replication of prototype and pandemic potential poxviruses
著者:: Jerzy Samolej, 等
出版事項: (2024-04-01)

Epstein-Barr virus (<i>Herpesviridae: Gammaherpesvirinae: Lymphocryptovirus: Human gammaherpesvirus 4</i>): replication strategies
著者:: S. A. Yakushina, 等
出版事項: (2020-09-01)

Inventory and Evolution of Mitochondrion-localized Family A DNA Polymerases in Euglenozoa
著者:: Ryo Harada, 等
出版事項: (2020-04-01)

Pol32, an accessory subunit of DNA polymerase delta, plays an essential role in genome stability and pathogenesis of Candida albicans
著者:: Shraddheya Kumar Patel, 等
出版事項: (2023-12-01)

Molecular Dissection of the Primase and Polymerase Activities of Deep-Sea Phage NrS-1 Primase-Polymerase
著者:: Fengtao Huang, 等
出版事項: (2021-12-01)

Beyond the Lesion: Back to High Fidelity DNA Synthesis
著者:: Joseph D. Kaszubowski, 等
出版事項: (2022-01-01)

Antiviral Activity of Acetylsalicylic Acid against Bunyamwera Virus in Cell Culture
著者:: Sara Yolanda Fernández-Sánchez, 等
出版事項: (2023-04-01)

The Loop of the TPR1 Subdomain of Phi29 DNA Polymerase Plays a Pivotal Role in Primer-Terminus Stabilization at the Polymerization Active Site
著者:: Alicia del Prado, 等
出版事項: (2019-10-01)

Detection and characterization of constitutive replication origins defined by DNA polymerase epsilon
著者:: Roman Jaksik, 等
出版事項: (2023-02-01)

Diverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells
著者:: Erik C Hansen, 等
出版事項: (2016-09-01)

RNA-Dependent RNA Polymerases of Picornaviruses: From the Structure to Regulatory Mechanisms
著者:: Cristina Ferrer-Orta, 等
出版事項: (2015-08-01)

Protein–Protein Interactions in Base Excision Repair
著者:: Govardhan Rathnaiah, 等
出版事項: (2025-06-01)

Mechanism of Hepatitis B Virus cccDNA Formation
著者:: Lei Wei, 等
出版事項: (2021-07-01)

Functional analysis of promoter element 2 within the viral polymerase gene of an emerging paramyxovirus, Sosuga virus
著者:: Lipi Akter, 等
出版事項: (2025-05-01)

Recent advancements in the diverse roles of polymerase-associated proteins in the replication and pathogenesis of Newcastle disease virus
著者:: Jinghang Zhou, 等
出版事項: (2025-01-01)

Dynamics of HBV cccDNA expression and transcription in different cell growth phase
著者:: Chong Chin-Liew, 等
出版事項: (2011-12-01)

Replication and transcription machinery for ranaviruses: components, correlation, and functional architecture
著者:: Fei Ke, 等
出版事項: (2022-01-01)

Interaction and assembly of the DNA replication core proteins of Kaposi’s sarcoma-associated herpesvirus
著者:: Lee-Wen Chen, 等
出版事項: (2023-12-01)