Traditional Herbal Medicine Mediated Regulations during Head and Neck Carcinogenesis
Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent neoplasms worldwide. It is well recognized that environmental challenges such as smoking, viral infection and alcohol consumption are key factors underlying HNSCC pathogenesis. Other than major clinical interventions (e.g., s...
| الحاوية / القاعدة: | Biomolecules |
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| المؤلفون الرئيسيون: | , , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
MDPI AG
2020-09-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://www.mdpi.com/2218-273X/10/9/1321 |
| _version_ | 1850406938246905856 |
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| author | Xiang-Yun Lan Tzu-Ting Chung Chien-Ling Huang Yi-Jang Lee Wan-Chun Li |
| author_facet | Xiang-Yun Lan Tzu-Ting Chung Chien-Ling Huang Yi-Jang Lee Wan-Chun Li |
| author_sort | Xiang-Yun Lan |
| collection | DOAJ |
| container_title | Biomolecules |
| description | Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent neoplasms worldwide. It is well recognized that environmental challenges such as smoking, viral infection and alcohol consumption are key factors underlying HNSCC pathogenesis. Other than major clinical interventions (e.g., surgical resection, chemical and radiotherapy) that have been routinely practiced over years, adjuvant anticancer agents from Traditional Herbal Medicine (THM) are proposed, either alone or together with conventional therapies, to be experimentally effective for improving treatment efficacy in different cancers including HNSCCs. At a cellular and molecular basis, THM extracts could modulate different malignant indices via distinct signaling pathways and provide better control in HNSCC malignancy and its clinical complications such as radiotherapy-induced xerostomia/oral mucositis. In this article, we aim to systemically review the impacts of THM in regulating HNSCC tumorous identities and its potential perspective for clinical use. |
| format | Article |
| id | doaj-art-db9d7cc382e84fd1a2dd2bec0cfc1cab |
| institution | Directory of Open Access Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-db9d7cc382e84fd1a2dd2bec0cfc1cab2025-08-19T22:48:05ZengMDPI AGBiomolecules2218-273X2020-09-01109132110.3390/biom10091321Traditional Herbal Medicine Mediated Regulations during Head and Neck CarcinogenesisXiang-Yun Lan0Tzu-Ting Chung1Chien-Ling Huang2Yi-Jang Lee3Wan-Chun Li4Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei 11221, TaiwanDepartment of Dentistry, School of Dentistry, National Yang-Ming University, Taipei 11221, TaiwanDepartment of Health Technology and Informatics (HTI), The Hong Kong Polytechnic University (PolyU), Hung Hom, Kowloon, Hong Kong, SAR, ChinaDepartment of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 11221, TaiwanInstitute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei 11221, TaiwanHead and neck squamous cell carcinoma (HNSCC) is one of the most prevalent neoplasms worldwide. It is well recognized that environmental challenges such as smoking, viral infection and alcohol consumption are key factors underlying HNSCC pathogenesis. Other than major clinical interventions (e.g., surgical resection, chemical and radiotherapy) that have been routinely practiced over years, adjuvant anticancer agents from Traditional Herbal Medicine (THM) are proposed, either alone or together with conventional therapies, to be experimentally effective for improving treatment efficacy in different cancers including HNSCCs. At a cellular and molecular basis, THM extracts could modulate different malignant indices via distinct signaling pathways and provide better control in HNSCC malignancy and its clinical complications such as radiotherapy-induced xerostomia/oral mucositis. In this article, we aim to systemically review the impacts of THM in regulating HNSCC tumorous identities and its potential perspective for clinical use.https://www.mdpi.com/2218-273X/10/9/1321head and neck cancertraditional herbal medicinetumor growthmetastasisangiogenesisxerostomia |
| spellingShingle | Xiang-Yun Lan Tzu-Ting Chung Chien-Ling Huang Yi-Jang Lee Wan-Chun Li Traditional Herbal Medicine Mediated Regulations during Head and Neck Carcinogenesis head and neck cancer traditional herbal medicine tumor growth metastasis angiogenesis xerostomia |
| title | Traditional Herbal Medicine Mediated Regulations during Head and Neck Carcinogenesis |
| title_full | Traditional Herbal Medicine Mediated Regulations during Head and Neck Carcinogenesis |
| title_fullStr | Traditional Herbal Medicine Mediated Regulations during Head and Neck Carcinogenesis |
| title_full_unstemmed | Traditional Herbal Medicine Mediated Regulations during Head and Neck Carcinogenesis |
| title_short | Traditional Herbal Medicine Mediated Regulations during Head and Neck Carcinogenesis |
| title_sort | traditional herbal medicine mediated regulations during head and neck carcinogenesis |
| topic | head and neck cancer traditional herbal medicine tumor growth metastasis angiogenesis xerostomia |
| url | https://www.mdpi.com/2218-273X/10/9/1321 |
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