Exploring cytokine levels in pregnancy, preeclampsia, and sepsis-complicated preeclampsia

Around the world, preeclampsia (PE) influences five to  eight percent of pregnancies and  contributes significantly to maternal mortality. This study applies a scientific observational cross-sectional review to examine how TNF-α, TNF-R1, and TNF-R2 play their roles in normal pregnancy, preeclampsia,...

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Bibliographic Details
Published in:Qanun Medika: Jurnal Kedokteran Fakultas Kedokteran Universitas Muhammadiyah Surabaya
Main Authors: Mira Kusuma Wardhani, Harry Kurniawan Gondo
Format: Article
Language:Indonesian
Published: Universitas Muhammadiyah Surabaya 2024-07-01
Subjects:
tnf levels
healthy pregnancy
preeclampsia
sepsis-complicated preeclampsia
Online Access:https://journal.um-surabaya.ac.id/qanunmedika/article/view/20427
Description
Summary:Around the world, preeclampsia (PE) influences five to  eight percent of pregnancies and  contributes significantly to maternal mortality. This study applies a scientific observational cross-sectional review to examine how TNF-α, TNF-R1, and TNF-R2 play their roles in normal pregnancy, preeclampsia, and  preeclampsia associated with  sepsis. Blood tests were gathered from subjects  at a  local medical clinic in Malang, Indonesia, and  TNF-α, TNF-R1, and TNF-R2 levels were surveyed utilizing the Enzyme-linked Immunosorbent Assay (ELISA) strategy. The results demonstrate raised TNF-α levels in both preeclampsia and preeclampsia with sepsis, along with expanded TNF-R1 and TNF-R2 receptor levels, signifying their association in these circumstances. Validation through bigger scope studies is basic, possibly situating TNF-α as an early indicative biomarker for sepsis. This study highlights the importance of TNF-α in pregnant mothers with preeclampsia and preeclampsia muddled by sepsis, uncovering possible analytic and remedial avenues.
ISSN:2541-2272
2548-9526

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