Promising Response with PI3K Inhibitor for a Patient with Heavily Pretreated PIK3CA Mutation Head-and-Neck Cancer
The treatment options for patients with head-and-neck squamous cell carcinoma (HNSCC) are limited when the disease progresses after taking platinum, a PD-1 inhibitor, and cetuximab. To develop new agents for managing such pretreated malignancies, therapies targeting carcinogenic pathways could be po...
| 出版年: | Journal of Cancer Research and Practice |
|---|---|
| 主要な著者: | Ming-Jing Lee, Hsiang-Fong Kao |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Wolters Kluwer Medknow Publications
2023-04-01
|
| 主題: | |
| オンライン・アクセス: | https://journals.lww.com/10.4103/ejcrp.eJCRP-D-22-00018 |
類似資料
Pulmonary Vein Stenosis Associated with Germline <i>PIK3CA</i> Mutation
著者:: Delphine Yung, 等
出版事項: (2022-05-01)
著者:: Delphine Yung, 等
出版事項: (2022-05-01)
Alpelisib and Immunotherapy: A Promising Combination for Recurrent and Metastatic Squamous Cell Carcinoma of the Head and Neck
著者:: Riham Suleiman, 等
出版事項: (2024-10-01)
著者:: Riham Suleiman, 等
出版事項: (2024-10-01)
Phase Ib and pharmacokinetics study of alpelisib, a PIK3CA inhibitor, and capecitabine in patients with advanced solid tumors
著者:: Ah Reum Lim, 等
出版事項: (2024-07-01)
著者:: Ah Reum Lim, 等
出版事項: (2024-07-01)
The effect of the alpha-specific PI3K inhibitor alpelisib combined with anti-HER2 therapy in HER2+/PIK3CA mutant breast cancer
著者:: Maria Letizia Cataldo, 等
出版事項: (2023-07-01)
著者:: Maria Letizia Cataldo, 等
出版事項: (2023-07-01)
Anticancer effects of alpelisib on PIK3CA-mutated canine mammary tumor cell lines
著者:: Jiah Yeom, 等
出版事項: (2023-11-01)
著者:: Jiah Yeom, 等
出版事項: (2023-11-01)
Target therapy of luminal HER2-negative advanced breast cancer with PIK3CA mutation: combination of alpelisib plus fulvestrant in real clinical practice
著者:: D. A. Filonenko, 等
出版事項: (2021-12-01)
著者:: D. A. Filonenko, 等
出版事項: (2021-12-01)
Acrofacial vitiligo secondary to PI3KCA inhibitor, alpelisib: case report
著者:: Maayan Geller Hinich, 等
出版事項: (2023-10-01)
著者:: Maayan Geller Hinich, 等
出版事項: (2023-10-01)
Integrating cfDNA liquid biopsy and organoid-based drug screening reveals PI3K signaling as a promising therapeutic target in colorectal cancer
著者:: Huan Yang, 等
出版事項: (2024-02-01)
著者:: Huan Yang, 等
出版事項: (2024-02-01)
Inhibitors of cyclin-dependent kinases 4/6 for breast cancer patients with different somatic mutations of the PIK3CA gene
著者:: A. F. Nasretdinov, 等
出版事項: (2020-12-01)
著者:: A. F. Nasretdinov, 等
出版事項: (2020-12-01)
Anti-PD1 prolongs the response of PI3K and farnesyl transferase inhibition in HRAS- and PIK3CA-mutant head and neck cancers
著者:: Dinesh Babu Manikandan, 等
出版事項: (2025-05-01)
著者:: Dinesh Babu Manikandan, 等
出版事項: (2025-05-01)
Understanding PI3K/Akt/mTOR signaling in squamous cell carcinoma: mutated PIK3CA as an example
著者:: Shutao Zheng, 等
出版事項: (2024-04-01)
著者:: Shutao Zheng, 等
出版事項: (2024-04-01)
Unaltered mRNA Levels of EGFR and PIK3CA in Head and Neck Squamous Cell Carcinoma
著者:: Neda Bafandeh, 等
出版事項: (2025-09-01)
著者:: Neda Bafandeh, 等
出版事項: (2025-09-01)
Somatic PIK3R1 mutations in the iSH2 domain are accessible to PI3Kα inhibition
著者:: Gabriel Morin, 等
出版事項: (2025-05-01)
著者:: Gabriel Morin, 等
出版事項: (2025-05-01)
Preventing alpelisib-related hyperglycaemia in HR+/HER2−/PIK3CA-mutated advanced breast cancer using metformin (METALLICA): a multicentre, open-label, single-arm, phase 2 trialResearch in context
著者:: Antonio Llombart-Cussac, 等
出版事項: (2024-05-01)
著者:: Antonio Llombart-Cussac, 等
出版事項: (2024-05-01)
Profiling PIK3CA variants in disorders of somatic mosaicism
著者:: Bahareh A. Mojarad, 等
出版事項: (2023-01-01)
著者:: Bahareh A. Mojarad, 等
出版事項: (2023-01-01)
Multiple PIK3CA mutation clonality correlates with outcomes in taselisib + fulvestrant-treated ER+/HER2–, PIK3CA-mutated breast cancers
著者:: Katherine E. Hutchinson, 等
出版事項: (2023-04-01)
著者:: Katherine E. Hutchinson, 等
出版事項: (2023-04-01)
PIK3CA-related overgrowth spectrum: animal model and drug discovery
著者:: Venot, Quitterie, 等
出版事項: (2021-07-01)
著者:: Venot, Quitterie, 等
出版事項: (2021-07-01)
Views on the Current Diagnosis and Treatment of PIK3CA-Related Overgrowth Spectrum
著者:: SUN Liying, 等
出版事項: (2023-10-01)
著者:: SUN Liying, 等
出版事項: (2023-10-01)
PIK3CA mutations in endocrine-resistant breast cancer
著者:: Caroline Schagerholm, 等
出版事項: (2024-05-01)
著者:: Caroline Schagerholm, 等
出版事項: (2024-05-01)
Detection of <i>PIK3CA</i> Gene Mutation in Head and Neck Squamous Cell Carcinoma Using Droplet Digital PCR and RT-qPCR
著者:: Edyta M. Borkowska, 等
出版事項: (2021-05-01)
著者:: Edyta M. Borkowska, 等
出版事項: (2021-05-01)
The way to precision medicine in gynecologic cancers: The first case report of an exceptional response to alpelisib in a PIK3CA-mutated endometrial cancer
著者:: Anna Passarelli, 等
出版事項: (2023-01-01)
著者:: Anna Passarelli, 等
出版事項: (2023-01-01)
Uncovering somatic mosaic variants of PIK3CA-related overgrowth disorders – three cases with different clinical presentations
著者:: M. Tooming, 等
出版事項: (2025-01-01)
著者:: M. Tooming, 等
出版事項: (2025-01-01)
PIK3CA-related overgrowth with an uncommon phenotype: case report
著者:: Roberta Rotunno, 等
出版事項: (2022-05-01)
著者:: Roberta Rotunno, 等
出版事項: (2022-05-01)
Real world outcomes with alpelisib in metastatic hormone receptor-positive breast cancer patients: A single institution experience
著者:: Sabah Alaklabi, 等
出版事項: (2022-10-01)
著者:: Sabah Alaklabi, 等
出版事項: (2022-10-01)
The Effect and Treatment of PIK3CA Mutations in Breast Cancer: Current Understanding and Future Directions
著者:: Young-Bin Cho, 等
出版事項: (2025-03-01)
著者:: Young-Bin Cho, 等
出版事項: (2025-03-01)
Biomarkers of cetuximab resistance in patients with head and neck squamous cell carcinoma
著者:: Olivia Leblanc, 等
出版事項: (2020-02-01)
著者:: Olivia Leblanc, 等
出版事項: (2020-02-01)
Safety findings from the phase 1/2 MOSAIC study of miransertib for patients with PIK3CA-related overgrowth spectrum or Proteus syndrome
著者:: Whitney Eng, 等
出版事項: (2025-07-01)
著者:: Whitney Eng, 等
出版事項: (2025-07-01)
Any Role of PIK3CA and PTEN Biomarkers in the Prognosis in Oral Squamous Cell Carcinoma?
著者:: Anna Starzyńska, 等
出版事項: (2020-12-01)
著者:: Anna Starzyńska, 等
出版事項: (2020-12-01)
PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma
著者:: Shota Tanaka, 等
出版事項: (2019-04-01)
著者:: Shota Tanaka, 等
出版事項: (2019-04-01)
CLOVES syndrome caused by mosaic mutation in the PIK3CA gene identified in fibroblasts
著者:: Magdalena Kłaniewska, 等
出版事項: (2021-07-01)
著者:: Magdalena Kłaniewska, 等
出版事項: (2021-07-01)
Results of multicenter testing of PIK3CA somatic mutations in hormone-receptor positive HER2-negative advanced breast cancer
著者:: Snježana Ramić, 等
出版事項: (2023-01-01)
著者:: Snježana Ramić, 等
出版事項: (2023-01-01)
Delineation of the phenotypes and genotypes of facial infiltrating lipomatosis associated with PIK3CA mutations
著者:: Hongrui Chen, 等
出版事項: (2023-07-01)
著者:: Hongrui Chen, 等
出版事項: (2023-07-01)
Case Report: Kaposiform hemangioendothelioma with PIK3CA mutation successfully treated with sirolimus
著者:: Zuopeng Wang, 等
出版事項: (2023-05-01)
著者:: Zuopeng Wang, 等
出版事項: (2023-05-01)
Cisplatin triggers cancer stem cell enrichment in platinum-resistant cells through NF-κB-TNFα-PIK3CA loop
著者:: Bhushan Thakur, 等
出版事項: (2017-11-01)
著者:: Bhushan Thakur, 等
出版事項: (2017-11-01)
Polymorphic GT Dinucleotide Repeat in the PIK3CA Gene and its Association with Colorectal Cancer Risk
著者:: Soha Parsafar, 等
出版事項: (2015-06-01)
著者:: Soha Parsafar, 等
出版事項: (2015-06-01)
Anti-tumor effects of low-dose metronomic vinorelbine in combination with alpelisib in breast cancer cells
著者:: Slavomir Krajnak, 等
出版事項: (2023-01-01)
著者:: Slavomir Krajnak, 等
出版事項: (2023-01-01)
PIK3CA exon 20 mutations are associated with poor prognosis in breast cancer patients
著者:: Flavia R. Mangone, 等
出版事項: (2012-11-01)
著者:: Flavia R. Mangone, 等
出版事項: (2012-11-01)
Mutation-Associated Phenotypic Heterogeneity in Novel and Canonical PIK3CA Helical and Kinase Domain Mutants
著者:: Arman Ali Ghodsinia, 等
出版事項: (2020-04-01)
著者:: Arman Ali Ghodsinia, 等
出版事項: (2020-04-01)
Mutations of the PIK3CA gene in patients with breast cancer in the Krasnoyarsk region
著者:: A. V. Zyuzyukina, 等
出版事項: (2024-07-01)
著者:: A. V. Zyuzyukina, 等
出版事項: (2024-07-01)
Association of PIK3CA somatic mutations with clinicopathological parameters in breast cancer
著者:: Gizem Teoman, 等
出版事項: (2024-12-01)
著者:: Gizem Teoman, 等
出版事項: (2024-12-01)
類似資料
-
Pulmonary Vein Stenosis Associated with Germline <i>PIK3CA</i> Mutation
著者:: Delphine Yung, 等
出版事項: (2022-05-01) -
Alpelisib and Immunotherapy: A Promising Combination for Recurrent and Metastatic Squamous Cell Carcinoma of the Head and Neck
著者:: Riham Suleiman, 等
出版事項: (2024-10-01) -
Phase Ib and pharmacokinetics study of alpelisib, a PIK3CA inhibitor, and capecitabine in patients with advanced solid tumors
著者:: Ah Reum Lim, 等
出版事項: (2024-07-01) -
The effect of the alpha-specific PI3K inhibitor alpelisib combined with anti-HER2 therapy in HER2+/PIK3CA mutant breast cancer
著者:: Maria Letizia Cataldo, 等
出版事項: (2023-07-01) -
Anticancer effects of alpelisib on PIK3CA-mutated canine mammary tumor cell lines
著者:: Jiah Yeom, 等
出版事項: (2023-11-01)
