Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease
Abstract Alcohol-related liver disease (ARLD) represents a major public health burden. Identification of high-risk individuals would allow efficient targeting of public health interventions. Here, we show significant interactions between pattern of drinking, genetic predisposition (polygenic risk sc...
| 發表在: | Nature Communications |
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| Main Authors: | , , , , , , , , , , |
| 格式: | Article |
| 語言: | 英语 |
| 出版: |
Nature Portfolio
2023-12-01
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| 在線閱讀: | https://doi.org/10.1038/s41467-023-43064-x |
| _version_ | 1850122669908819968 |
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| author | Chengyi Ding Linda Ng Fat Annie Britton Pek Kei Im Kuang Lin Anya Topiwala Liming Li Zhengming Chen Iona Y. Millwood Steven Bell Gautam Mehta |
| author_facet | Chengyi Ding Linda Ng Fat Annie Britton Pek Kei Im Kuang Lin Anya Topiwala Liming Li Zhengming Chen Iona Y. Millwood Steven Bell Gautam Mehta |
| author_sort | Chengyi Ding |
| collection | DOAJ |
| container_title | Nature Communications |
| description | Abstract Alcohol-related liver disease (ARLD) represents a major public health burden. Identification of high-risk individuals would allow efficient targeting of public health interventions. Here, we show significant interactions between pattern of drinking, genetic predisposition (polygenic risk score, PRS) and diabetes mellitus, and risk of incident ARLD, in 312,599 actively drinking adults in UK Biobank. Binge and heavy binge drinking significantly increase the risk of alcohol-related cirrhosis (ARC), with higher genetic predisposition further amplifying the risk. Further, we demonstrate a pronounced interaction between heavy binge drinking and high PRS, resulting in a relative excess risk due to interaction (RERI) of 6.07. Diabetes consistently elevates ARC risk across all drinking and PRS categories, and showed significant interaction with both binge patterns and genetic risk. Overall, we demonstrate synergistic effects of binge drinking, genetics, and diabetes on ARC, with potential to identify high-risk individuals for targeted interventions. |
| format | Article |
| id | doaj-art-dcafe0e689764fa7be18ce55e256937a |
| institution | Directory of Open Access Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| spelling | doaj-art-dcafe0e689764fa7be18ce55e256937a2025-08-19T23:55:42ZengNature PortfolioNature Communications2041-17232023-12-011411810.1038/s41467-023-43064-xBinge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver diseaseChengyi Ding0Linda Ng Fat1Annie Britton2Pek Kei Im3Kuang Lin4Anya Topiwala5Liming Li6Zhengming Chen7Iona Y. Millwood8Steven Bell9Gautam Mehta10Division of Psychiatry, University College LondonResearch Department of Epidemiology and Public Health, University College LondonResearch Department of Epidemiology and Public Health, University College LondonClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of OxfordClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of OxfordBig Data Institute, Nuffield Department of Population Health, University of OxfordDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science CenterClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of OxfordClinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of OxfordPrecision Breast Cancer Institute, Department of Oncology, University of CambridgeInstitute for Liver and Digestive Health, University College LondonAbstract Alcohol-related liver disease (ARLD) represents a major public health burden. Identification of high-risk individuals would allow efficient targeting of public health interventions. Here, we show significant interactions between pattern of drinking, genetic predisposition (polygenic risk score, PRS) and diabetes mellitus, and risk of incident ARLD, in 312,599 actively drinking adults in UK Biobank. Binge and heavy binge drinking significantly increase the risk of alcohol-related cirrhosis (ARC), with higher genetic predisposition further amplifying the risk. Further, we demonstrate a pronounced interaction between heavy binge drinking and high PRS, resulting in a relative excess risk due to interaction (RERI) of 6.07. Diabetes consistently elevates ARC risk across all drinking and PRS categories, and showed significant interaction with both binge patterns and genetic risk. Overall, we demonstrate synergistic effects of binge drinking, genetics, and diabetes on ARC, with potential to identify high-risk individuals for targeted interventions.https://doi.org/10.1038/s41467-023-43064-x |
| spellingShingle | Chengyi Ding Linda Ng Fat Annie Britton Pek Kei Im Kuang Lin Anya Topiwala Liming Li Zhengming Chen Iona Y. Millwood Steven Bell Gautam Mehta Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease |
| title | Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease |
| title_full | Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease |
| title_fullStr | Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease |
| title_full_unstemmed | Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease |
| title_short | Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease |
| title_sort | binge pattern alcohol consumption and genetic risk as determinants of alcohol related liver disease |
| url | https://doi.org/10.1038/s41467-023-43064-x |
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