Adiponectin/Leptin Ratio as an Index to Determine Metabolic Risk in Patients after Kidney Transplantation

• 發表在: Medicina
• Main Authors: Karol Graňák, Matej Vnučák, Monika Beliančinová, Patrícia Kleinová, Margaréta Pytliaková, Juraj Miklušica, Ivana Dedinská
• 格式: Article
• 語言: 英语
• 出版: MDPI AG 2022-11-01
• 主題: adiponectin/leptin ratio; kidney transplantation; posttransplant diabetes mellitus
• 在線閱讀: https://www.mdpi.com/1648-9144/58/11/1656
• ISSN: 1010-660X; 1648-9144

<i>Background and Objectives:</i> It has been confirmed that adiponectin/leptin (A/L) ratio correlates better with cardiometabolic risk factors than hormone levels alone. The aim of our study was to determine the risk of developing post-transplant diabetes mellitus (PTDM) and other metabolic conditions depending on A/L ratio after kidney transplantation (KT). <i>Material and Methods</i>: In a prospective analysis, the studied samples were divided into three groups: control group, prediabetes and PTDM group. Pre-transplantation, at 3, 6 and 12 months after KT, we recorded basic characteristics of donor and recipient. We also monitored levels of adipocytokines and calculated A/L ratio. <i>Results</i>: During observed period, we recorded significant increase in A/L ratio in control group (<i>p</i> = 0.0013), on the contrary, a significant decrease in PTDM group (<i>p</i> = 0.0003). Using Cox regression Hazard model, we identified age at time of KT (HR 2.8226, <i>p</i> = 0.0225), triglycerides at 1 year (HR 3.5735, <i>p</i> = 0.0174) and A/L ratio < 0.5 as independent risk factors for prediabetes and PTDM 1-year post-transplant (HR 3.1724, <i>p</i> = 0.0114). <i>Conclusions:</i> This is the first study to evaluate the relationship between A/L and risk of PTDM and associated metabolic states after KT. We found out that A/L ratio <0.5 is independent risk factor for prediabetes and PTDM 1 year post-transplant.