High-confidence glycosomal membrane protein inventory unveils trypanosomal peroxin PEX15
Summary: Trypanosomatid parasite infections cause Chagas disease, human African trypanosomiasis, and leishmaniasis, affecting over 12 million people worldwide. Glycosomes, the peroxisome-related organelles of trypanosomes, are essential for survival, making their metabolic functions and biogenesis m...
| Published in: | Cell Reports |
|---|---|
| Main Authors: | Chethan K. Krishna, Hirak Das, Lisa Hohnen, Wolfgang Schliebs, Silke Oeljeklaus, Bettina Warscheid, Vishal C. Kalel, Ralf Erdmann |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-05-01
|
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725003857 |
Similar Items
Molecular basis of the glycosomal targeting of PEX11 and its mislocalization to mitochondrion in trypanosomes
by: Chethan K. Krishna, et al.
Published: (2023-08-01)
by: Chethan K. Krishna, et al.
Published: (2023-08-01)
PEX1 is essential for glycosome biogenesis and trypanosomatid parasite survival
by: Lavanya Mahadevan, et al.
Published: (2024-03-01)
by: Lavanya Mahadevan, et al.
Published: (2024-03-01)
Inhibitors of glycosomal protein import provide new leads against trypanosomiasis
by: Vishal C. Kalel, et al.
Published: (2017-07-01)
by: Vishal C. Kalel, et al.
Published: (2017-07-01)
The rice peroxisomal receptor PEX5 negatively regulates resistance to rice blast fungus Magnaporthe oryzae
by: Xiaoman You, et al.
Published: (2023-10-01)
by: Xiaoman You, et al.
Published: (2023-10-01)
Immunodominant surface epitopes power immune evasion in the African trypanosome
by: Anastasia Gkeka, et al.
Published: (2023-03-01)
by: Anastasia Gkeka, et al.
Published: (2023-03-01)
The Structure of the Arabidopsis PEX4-PEX22 Peroxin Complex—Insights Into Ubiquitination at the Peroxisomal Membrane
by: Melissa S. Traver, et al.
Published: (2022-02-01)
by: Melissa S. Traver, et al.
Published: (2022-02-01)
Confidence bias prescribes the neurocomputational mechanism of decision-making
by: Fanru Sun, et al.
Published: (2025-05-01)
by: Fanru Sun, et al.
Published: (2025-05-01)
A population representation of the confidence in a decision in the parietal cortex
by: Ariel Zylberberg, et al.
Published: (2025-04-01)
by: Ariel Zylberberg, et al.
Published: (2025-04-01)
Peroxin FgPEX22-Like Is Involved in FgPEX4 Tethering and Fusarium graminearum Pathogenicity
by: Li Zhang, et al.
Published: (2021-12-01)
by: Li Zhang, et al.
Published: (2021-12-01)
Glycosome biogenesis in trypanosomes and the de novo dilemma.
by: Sarah Bauer, et al.
Published: (2017-04-01)
by: Sarah Bauer, et al.
Published: (2017-04-01)
Pex14p Phosphorylation Modulates Import of Citrate Synthase 2 Into Peroxisomes in Saccharomyces cerevisiae
by: Andreas Schummer, et al.
Published: (2020-09-01)
by: Andreas Schummer, et al.
Published: (2020-09-01)
An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease
by: Marcell Harhai, et al.
Published: (2025-08-01)
by: Marcell Harhai, et al.
Published: (2025-08-01)
Hansenula polymorpha cells lacking the ER-localized peroxins Pex23 or Pex29 show defects in mitochondrial function and morphology
by: Haiqiong Chen, et al.
Published: (2024-05-01)
by: Haiqiong Chen, et al.
Published: (2024-05-01)
Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders
by: Han Gao, et al.
Published: (2023-06-01)
by: Han Gao, et al.
Published: (2023-06-01)
The zebrafish heart harbors a thermogenic beige fat depot analog of human epicardial adipose tissue
by: Paul-Andres Morocho-Jaramillo, et al.
Published: (2024-03-01)
by: Paul-Andres Morocho-Jaramillo, et al.
Published: (2024-03-01)
A Small Molecule Inhibitor of Pex3–Pex19 Interaction Disrupts Glycosome Biogenesis and Causes Lethality in Trypanosoma brucei
by: Hiren Banerjee, et al.
Published: (2021-07-01)
by: Hiren Banerjee, et al.
Published: (2021-07-01)
The Early-Acting Peroxin PEX19 Is Redundantly Encoded, Farnesylated, and Essential for Viability in Arabidopsis thaliana.
by: Margaret M McDonnell, et al.
Published: (2016-01-01)
by: Margaret M McDonnell, et al.
Published: (2016-01-01)
SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck
by: Nupur Nigam, et al.
Published: (2023-07-01)
by: Nupur Nigam, et al.
Published: (2023-07-01)
Integrative Omics reveals changes in the cellular landscape of peroxisome-deficient pex3 yeast cells
by: Tjasa Kosir, et al.
Published: (2025-02-01)
by: Tjasa Kosir, et al.
Published: (2025-02-01)
Identifying potential dietary treatments for inherited metabolic disorders using Drosophila nutrigenomics
by: Felipe Martelli, et al.
Published: (2024-03-01)
by: Felipe Martelli, et al.
Published: (2024-03-01)
A trypanosomal orthologue of an intermembrane space chaperone has a non-canonical function in biogenesis of the single mitochondrial inner membrane protein translocase.
by: Christoph Wenger, et al.
Published: (2017-08-01)
by: Christoph Wenger, et al.
Published: (2017-08-01)
Endogenous viral elements in termite genomes reveal extensive diversity of deltaviruses and provide insights into their origins
by: Jose Gabriel Nino Barreat, et al.
Published: (2025-09-01)
by: Jose Gabriel Nino Barreat, et al.
Published: (2025-09-01)
Integrative genomic identification of therapeutic targets for pancreatic cancer
by: Jimmy A. Guo, et al.
Published: (2025-09-01)
by: Jimmy A. Guo, et al.
Published: (2025-09-01)
A capsular polysaccharide from a healthy human microbiota member activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy
by: Allison M. Weis, et al.
Published: (2025-09-01)
by: Allison M. Weis, et al.
Published: (2025-09-01)
Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism
by: Aprajita Tripathi, et al.
Published: (2025-09-01)
by: Aprajita Tripathi, et al.
Published: (2025-09-01)
Human brain cell types shape host-rabies virus transcriptional interactions revealing a preexisting pro-viral astrocyte subpopulation
by: Lena Feige, et al.
Published: (2025-09-01)
by: Lena Feige, et al.
Published: (2025-09-01)
C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer
by: Ran Liu, et al.
Published: (2025-09-01)
by: Ran Liu, et al.
Published: (2025-09-01)
Gut commensal microbiota drive tailored macrophage responses
by: Josh Jones, et al.
Published: (2025-08-01)
by: Josh Jones, et al.
Published: (2025-08-01)
Spatiotemporal profiling reveals the impact of caloric restriction in the aging mammalian brain
by: Zehao Zhang, et al.
Published: (2025-09-01)
by: Zehao Zhang, et al.
Published: (2025-09-01)
Exogenous estrogen enhances T cell activation in male primates
by: Patricia A. Hahn, et al.
Published: (2025-09-01)
by: Patricia A. Hahn, et al.
Published: (2025-09-01)
A comprehensive analysis of supermere, exomere, and extracellular vesicle isolation and cargo in colorectal cancer
by: Oleg S. Tutanov, et al.
Published: (2025-10-01)
by: Oleg S. Tutanov, et al.
Published: (2025-10-01)
Disruption of fibroblast MYD88 signaling promotes antitumor immunity in pancreatic ductal adenocarcinoma
by: Maria Korah, et al.
Published: (2025-10-01)
by: Maria Korah, et al.
Published: (2025-10-01)
Gut metagenome and plasma metabolome profiles in older adults suggest pyruvate metabolism as a link between sleep quality and frailty
by: Yanni Pu, et al.
Published: (2025-10-01)
by: Yanni Pu, et al.
Published: (2025-10-01)
Metabolic reprogramming in the spinal cord drives the transition to pain chronicity
by: Alex Mabou Tagne, et al.
Published: (2025-09-01)
by: Alex Mabou Tagne, et al.
Published: (2025-09-01)
The major role of the REL2/NF-κB pathway in the regulation of midgut bacterial homeostasis in the malaria vector Anopheles gambiae
by: Suzana Zaković, et al.
Published: (2025-09-01)
by: Suzana Zaković, et al.
Published: (2025-09-01)
Evolution of a melanoma that escapes allogeneic rejection
by: Ahmed Rokan, et al.
Published: (2025-09-01)
by: Ahmed Rokan, et al.
Published: (2025-09-01)
Early adipose tissue wasting in a preclinical model of human lung cancer cachexia
by: Deena B. Snoke, et al.
Published: (2025-09-01)
by: Deena B. Snoke, et al.
Published: (2025-09-01)
Integrated spatial transcriptomic profiling to dissect the cellular characteristics of tumor-associated tertiary lymphoid structures
by: Xiangjie Li, et al.
Published: (2025-09-01)
by: Xiangjie Li, et al.
Published: (2025-09-01)
Temporal control of eating and body weight by GHSR-expressing suprachiasmatic nucleus neurons
by: Omprakash Singh, et al.
Published: (2025-09-01)
by: Omprakash Singh, et al.
Published: (2025-09-01)
Hypoxic stress dysregulates functions of glioma-associated myeloid cells through epigenomic and transcriptional programs
by: Monika Dzwigonska, et al.
Published: (2025-09-01)
by: Monika Dzwigonska, et al.
Published: (2025-09-01)
Similar Items
-
Molecular basis of the glycosomal targeting of PEX11 and its mislocalization to mitochondrion in trypanosomes
by: Chethan K. Krishna, et al.
Published: (2023-08-01) -
PEX1 is essential for glycosome biogenesis and trypanosomatid parasite survival
by: Lavanya Mahadevan, et al.
Published: (2024-03-01) -
Inhibitors of glycosomal protein import provide new leads against trypanosomiasis
by: Vishal C. Kalel, et al.
Published: (2017-07-01) -
The rice peroxisomal receptor PEX5 negatively regulates resistance to rice blast fungus Magnaporthe oryzae
by: Xiaoman You, et al.
Published: (2023-10-01) -
Immunodominant surface epitopes power immune evasion in the African trypanosome
by: Anastasia Gkeka, et al.
Published: (2023-03-01)
