In Silico Evaluation of the Biopharmaceutical and Pharmacokinetic Behavior of Metronidazole from Coated Colonic Release Matrix Tablets

<b>Background:</b> Physiologically based biopharmaceutics modeling (PBBM) models can help to predict drug release and in vivo absorption behaviors. Colon drug delivery systems have gained interest over the past few years due to the advantages they provide in treating certain diseases in...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Roberto Arévalo-Pérez, Cristina Maderuelo, José M. Lanao
Format:	Article
Language:	English
Published:	MDPI AG 2025-05-01
Subjects:	SIMCYP physiologically based pharmacokinetic modeling (PBPK) physiologically based biopharmaceutics modeling (PBBM) advanced dissolution absorption model (ADAM) biopharmaceutical simulations pharmacokinetics
Online Access:	https://www.mdpi.com/1999-4923/17/5/647