Identifying in-market application of Pelargonium root extract EPs 7630 for the treatment of COVID-19: analysis of pharmacovigilance data

Introduction: Phytopharmaceutical products are successfully used for acute respiratory infections and may therefore be promising candidates for adjuvant symptomatic treatment of COVID-19. In vitro and clinical studies suggest that the proprietary Pelargonium sidoides DC. root extract EPs 7630 has an...

Full description

Bibliographic Details
Published in:	Frontiers in Pharmacology
Main Authors:	Fathi Abdul Malek, Petra Funk
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Subjects:	Pelargonium sidoides root extract (EPs 7630) off-label use case reports COVID-19 spontaneous reporting safety
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1335309/full

Similar Items

Pelargonium sidoides extract EPs 7630: a review of its clinical efficacy and safety for treating acute respiratory tract infections in children
by: Careddu D, et al.
Published: (2018-03-01)

African Geranium (Pelargonium sidoides) in the Treatment of Acute Respiratory Tract Infections: A Review of Mechanisms of Action, Efficacy, and Clinical Applications
by: Anna Kwasniewska, et al.
Published: (2025-04-01)

In vitro and in vivo effects of Pelargonium sidoides DC. root extract EPs® 7630 and selected constituents against SARS-CoV-2 B.1, Delta AY.4/AY.117 and Omicron BA.2
by: Jackson Emanuel, et al.
Published: (2023-07-01)

Development and application of a chemical profiling method for the assessment of the quality and consistency of the Pelargonium sidoides extract
by: Se Mi Yu, et al.
Published: (2021-10-01)

Unlocking the therapeutic potential of Pelargonium sidoides natural extract: A scoping review
by: Bárbara Donadon Reina, et al.
Published: (2024-12-01)

Long-term benefits of EPs® 7630 in patients with acute sinusitis: a real-world cohort study
by: Matthias Tisch, et al.
Published: (2024-03-01)

Initially purported hepatotoxicity by Pelargonium sidoides: the dilemma of pharmacovigilance and proposals for improvement
by: Rolf Teschke, M.D., et al.
Published: (2012-07-01)

Pelargonium root (Pelargonium sidoides DC) extract in paediatric patients - food supplement or medicine?
by: Baraniak Justyna, et al.
Published: (2020-06-01)

Prescription of EPs 7630 is associated with short- and long-term benefits in acute bronchitis: a real-world data analysis
by: Adrian Gillissen, et al.
Published: (2025-09-01)

Cultivation and beneficial uses of Pelargonium sidoides DC. – A review
by: Yandiswa Mtimkulu, et al.
Published: (2024-05-01)

Up-Regulated Vitamin D Receptor by <i>Pelargonium sidoides</i> Extract EPs<sup>®</sup> 7630 Contributes to Rhinovirus Defense in Bronchial Epithelial Cells
by: Michael Roth, et al.
Published: (2021-02-01)

Hand, foot, and mouth disease: could EPs® 7630 be a treatment option? A prospective randomized open-label multicenter clinical study
by: Murat Sütçü, et al.
Published: (2024-05-01)

Immunomodulatory Effects of Pelargonium sidoides Extract (EPs7630) in the Treatment of Acute Rhinosinusitis
by: Aleksandar Perić, et al.
Published: (2025-01-01)

Possibilities of using combined drugs in the treatment of nasal obstruction syndrome
by: S. V. Ryazantsev, et al.
Published: (2021-05-01)

<i>Pelargonium sidoides</i> Root Extract: Simultaneous HPLC Separation, Determination, and Validation of Selected Biomolecules and Evaluation of SARS-CoV-2 Inhibitory Activity
by: Manal A. Alossaimi, et al.
Published: (2022-09-01)

Vermicompost leachates enhance morpho-physiological properties in Pelargonium sidoides DC
by: McMaster Vambe, et al.
Published: (2024-06-01)

Open, Randomised, Controlled Study to Evaluate the Role of a Dietary Supplement Containing <i>Pelargonium sidoides</i> Extract, Honey, Propolis, and Zinc as Adjuvant Treatment in Children with Acute Tonsillopharyngitis
by: Fabio Cardinale, et al.
Published: (2025-03-01)

Efficacy and Safety of YJP-40 in Patients with Acute Bronchitis: A Randomized, Double-Blind, Parallel Group Study
by: Chin Kook Rhee
Published: (2025-07-01)

Stevens’ Cure (Umckaloabo)—the vindication of a patent medicine
by: T. Brendler, et al.
Published: (2024-01-01)

Effect of Meta-topolin on in vitro propagation of Pelargonium × hortorum and Pelargonium × hederaefolium cultivars
by: Agnieszka Wojtania
Published: (2011-01-01)

Water stress enhances geranium (Pelargonium) cuttings rooting quality
by: Yaarit Kutsher, et al.
Published: (2022-04-01)

Possibilities of phytotherapy in the treatment of acute respiratory infections in children
by: I. N. Kholodova
Published: (2022-05-01)

Efficacy and Safety of a Novel Gummy Formulation for the Management of Cough in Adults: Double Blind, Randomized, Placebo-Controlled Trial
by: Domenico Leonardo Grasso, et al.
Published: (2022-03-01)

Herbal hepatotoxicity and WHO global introspection method
by: Rolf Teschke, M.D., et al.
Published: (2013-01-01)

Pelargonium endlicherianum Fenzl. Root Extract Suppresses Cell Proliferation of Prostate Cancer Cells
by: Selda Eren, et al.
Published: (2017-11-01)

Clinical and microbiological rationale for the use of a herbal preparation in children with rhinopharyngitis
by: O. E. Chelpachenko, et al.
Published: (2022-03-01)

Modern possibilities of herbal medicine in the treatment of acute inflammatory diseases of the upper respiratory tract
by: A. V. Gurov, et al.
Published: (2021-12-01)

Collection of Pelargonium genus: history of formation and development prospects
by: Nadezhda Gutiyeva
Published: (2014-12-01)

Functional Analysis of Four Terpene Synthases in Rose-Scented Pelargonium Cultivars (Pelargonium × hybridum) and Evolution of Scent in the Pelargonium Genus
by: Bernard Blerot, et al.
Published: (2018-11-01)

Anti-Inflammatory Potential of Umckalin Through the Inhibition of iNOS, COX-2, Pro-Inflammatory Cytokines, and MAPK Signaling in LPS-Stimulated RAW 264.7 Cells
by: So-Yeon Oh, et al.
Published: (2025-01-01)

Application of a herbal preparation in the therapy of acute tonzillopharyngitis in children
by: O. V. Borisova, et al.
Published: (2021-11-01)

Significant Broad-Spectrum Antiviral Activity of Bi121 against Different Variants of SARS-CoV-2
by: Bobban Subhadra, et al.
Published: (2023-05-01)

Enhancing genetic diversity in Pelargonium: insights from crossbreeding in the gene pool
by: Özgül Karagüzel, et al.
Published: (2024-09-01)

The effect of organic and chemical fertilization on vegetative and floral characteristics of Pelargonium graveolens L.
by: Raghad Tahrir Salim Al-Shallal, et al.
Published: (2021-06-01)

Aclimatização de mudas micropropagadas de gerânio (<i>Pelargonium</i> <i>graveolens</i> L.)
by: Ana Catarina Lima de Oliveira, et al.
Published: (2007-06-01)

Plastid-encoded RNA polymerase variation in Pelargonium sect Ciconium
by: FC Breman, et al.
Published: (2024-01-01)

Influence of Compost from Post-Consumer Wood on Development, Nutrition State of Plants, Microbiological and Biochemical Parameters of Substrates in Zonal Pelargonium (<i>Pelargonium zonale</i>)
by: Anita Schroeter-Zakrzewska, et al.
Published: (2021-05-01)

CHEMICAL CONSTITUENTS AND BIOLOGICAL ACTIVITIES OF ESSENTIAL OILS OF THE SPECIES Malva sylvestrisand Pelargonium graveolens: A REVIEW
by: Janine Machado Oliveira
Published: (2021-07-01)

Luminosidade e interação de reguladores de crescimento na micropropagação de gerânio (<i>Pelargonium</i> <i>graveolens</i> L)
by: Ana Catarina Lima de Oliveira, et al.
Published: (2007-06-01)

Nickel(II) and cadmium(II) uptake by carbon iron composite derived from Pelargonium graveolens
by: P.M. Thabede, et al.
Published: (2025-06-01)