Hepcidin–Minireview
Iron related disorders are encountered in daily clinical settings. Maintenance of stable extracellular iron concentrations requires the coordinate regulation of iron transport into plasma from dietary sources in the duodenum, from recycled senescent red cells in macrophages and from storage in hep...
| الحاوية / القاعدة: | Journal of Clinical and Diagnostic Research |
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| المؤلفون الرئيسيون: | , , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
JCDR Research and Publications Private Limited
2013-08-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://jcdr.net/articles/PDF/3273/78-%206420_E(C)_PF1(M)_F(P)_PF1(P)_PFA(PP).pdf |
| الملخص: | Iron related disorders are encountered in daily clinical settings. Maintenance of stable extracellular iron concentrations requires
the coordinate regulation of iron transport into plasma from dietary sources in the duodenum, from recycled senescent red cells in
macrophages and from storage in hepatocytes. Hepcidin acts as a systemic iron-regulatory hormone. Many human diseases are
associated with alterations in hepcidin concentrations. This review has focused on hepcidin structure, kinetics and function, its correlation
with iron metabolism disorders, the therapeutic potential for modulating hepcidin expression and the diagnostic potential of hepcidin
measurements in clinical practice. |
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| تدمد: | 2249-782X 0973-709X |