The Golgi Apparatus May Be a Potential Therapeutic Target for Apoptosis-Related Neurological Diseases
Increasing evidence shows that, in addition to the classical function of protein processing and transport, the Golgi apparatus (GA) is also involved in apoptosis, one of the most common forms of cell death. The structure and the function of the GA is damaged during apoptosis. However, the specific e...
| 出版年: | Frontiers in Cell and Developmental Biology |
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| 主要な著者: | , , , , , , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Frontiers Media S.A.
2020-08-01
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| 主題: | |
| オンライン･アクセス: | https://www.frontiersin.org/article/10.3389/fcell.2020.00830/full |
| _version_ | 1857034512127492096 |
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| author | Qiang He Hui Liu Shuwen Deng Xiqian Chen Dong Li Xuan Jiang Wenbo Zeng Wei Lu |
| author_facet | Qiang He Hui Liu Shuwen Deng Xiqian Chen Dong Li Xuan Jiang Wenbo Zeng Wei Lu |
| author_sort | Qiang He |
| collection | DOAJ |
| container_title | Frontiers in Cell and Developmental Biology |
| description | Increasing evidence shows that, in addition to the classical function of protein processing and transport, the Golgi apparatus (GA) is also involved in apoptosis, one of the most common forms of cell death. The structure and the function of the GA is damaged during apoptosis. However, the specific effect of the GA on the apoptosis process is unclear; it may be involved in initiating or promoting apoptosis, or it may inhibit apoptosis. Golgi-related apoptosis is associated with a variety of neurological diseases including glioma, Alzheimer’s disease (AD), Parkinson’s disease (PD), and ischemic stroke. This review summarizes the changes and the possible mechanisms of Golgi structure and function during apoptosis. In addition, we also explore the possible mechanisms by which the GA regulates apoptosis and summarize the potential relationship between the Golgi and certain neurological diseases from the perspective of apoptosis. Elucidation of the interaction between the GA and apoptosis broadens our understanding of the pathological mechanisms of neurological diseases and provides new research directions for the treatment of these diseases. Therefore, we propose that the GA may be a potential therapeutic target for apoptosis-related neurological diseases. |
| format | Article |
| id | doaj-art-dfd21ccf2b2f4b9889b7360a7cb0fa08 |
| institution | Directory of Open Access Journals |
| issn | 2296-634X |
| language | English |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| spelling | doaj-art-dfd21ccf2b2f4b9889b7360a7cb0fa082025-08-19T19:38:53ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-08-01810.3389/fcell.2020.00830560159The Golgi Apparatus May Be a Potential Therapeutic Target for Apoptosis-Related Neurological DiseasesQiang He0Hui Liu1Shuwen Deng2Xiqian Chen3Dong Li4Xuan Jiang5Wenbo Zeng6Wei Lu7Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, ChinaState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, ChinaState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, ChinaState Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, ChinaDepartment of Neurology, The Second Xiangya Hospital, Central South University, Changsha, ChinaIncreasing evidence shows that, in addition to the classical function of protein processing and transport, the Golgi apparatus (GA) is also involved in apoptosis, one of the most common forms of cell death. The structure and the function of the GA is damaged during apoptosis. However, the specific effect of the GA on the apoptosis process is unclear; it may be involved in initiating or promoting apoptosis, or it may inhibit apoptosis. Golgi-related apoptosis is associated with a variety of neurological diseases including glioma, Alzheimer’s disease (AD), Parkinson’s disease (PD), and ischemic stroke. This review summarizes the changes and the possible mechanisms of Golgi structure and function during apoptosis. In addition, we also explore the possible mechanisms by which the GA regulates apoptosis and summarize the potential relationship between the Golgi and certain neurological diseases from the perspective of apoptosis. Elucidation of the interaction between the GA and apoptosis broadens our understanding of the pathological mechanisms of neurological diseases and provides new research directions for the treatment of these diseases. Therefore, we propose that the GA may be a potential therapeutic target for apoptosis-related neurological diseases.https://www.frontiersin.org/article/10.3389/fcell.2020.00830/fullGolgi apparatusapoptosiscaspasesneurological diseasestherapeutic target |
| spellingShingle | Qiang He Hui Liu Shuwen Deng Xiqian Chen Dong Li Xuan Jiang Wenbo Zeng Wei Lu The Golgi Apparatus May Be a Potential Therapeutic Target for Apoptosis-Related Neurological Diseases Golgi apparatus apoptosis caspases neurological diseases therapeutic target |
| title | The Golgi Apparatus May Be a Potential Therapeutic Target for Apoptosis-Related Neurological Diseases |
| title_full | The Golgi Apparatus May Be a Potential Therapeutic Target for Apoptosis-Related Neurological Diseases |
| title_fullStr | The Golgi Apparatus May Be a Potential Therapeutic Target for Apoptosis-Related Neurological Diseases |
| title_full_unstemmed | The Golgi Apparatus May Be a Potential Therapeutic Target for Apoptosis-Related Neurological Diseases |
| title_short | The Golgi Apparatus May Be a Potential Therapeutic Target for Apoptosis-Related Neurological Diseases |
| title_sort | golgi apparatus may be a potential therapeutic target for apoptosis related neurological diseases |
| topic | Golgi apparatus apoptosis caspases neurological diseases therapeutic target |
| url | https://www.frontiersin.org/article/10.3389/fcell.2020.00830/full |
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