Phytochemical Screening, GC-MS Analysis, and Evaluating In Vivo Antitrypanosomal Effects of a Methanolic Extract of <i>Garcinia kola</i> Nuts on Rats

Trypanosomiasis is a serious disease that affects both humans and animals, causing social and economic losses. Efforts to find new therapeutic approaches are warranted to improve treatment options. Therefore, the purpose of this communication includes the phytochemical screening of a methanolic extr...

Full description

Bibliographic Details
Published in:	Antibiotics
Main Authors:	Fatihu Ahmad Rufa’i, Daniel Baecker, Muhammad Dauda Mukhtar
Format:	Article
Language:	English
Published:	MDPI AG 2023-04-01
Subjects:	<i>Garcinia kola</i> methanolic extract sleeping sickness suramin <i>Trypanosoma brucei brucei</i> trypanosomiasis
Online Access:	https://www.mdpi.com/2079-6382/12/4/713

Similar Items

African Trypanosomiasis: Extracellular Vesicles Shed by <i>Trypanosoma brucei brucei</i> Manipulate Host Mononuclear Cells
by: Tatiana Dias-Guerreiro, et al.
Published: (2021-08-01)

Antitrypanosomal and Antileishmanial Activity of Chalcones and Flavanones from <i>Polygonum salicifolium</i>
by: Ahmed M. Zheoat, et al.
Published: (2021-02-01)

Synthesis, Structure and In Vitro Anti-Trypanosomal Activity of Non-Toxic Arylpyrrole-Based Chalcone Derivatives
by: Ayanda I. Zulu, et al.
Published: (2020-04-01)

Reanalyzing the 1900–1920 Sleeping Sickness Epidemic in Uganda
by: E.M. Fèvre, et al.
Published: (2004-04-01)

Antitrypanosomal Activity of <i>Anthriscus</i> Nemorosa Essential Oils and Combinations of Their Main Constituents
by: Cecilia Baldassarri, et al.
Published: (2021-11-01)

Chemical Derivatization and Characterization of Novel Antitrypanosomals for African Trypanosomiasis
by: Aboagye Kwarteng Dofuor, et al.
Published: (2021-07-01)

Fexinidazole for Human African Trypanosomiasis, the Fruit of a Successful Public-Private Partnership
by: Sonja Bernhard, et al.
Published: (2022-10-01)

Two-Year Follow-Up of <i>Trypanosoma brucei gambiense</i> Serology after Successful Treatment of Human African Trypanosomiasis: Results of Four Different Sero-Diagnostic Tests
by: Raquel Inocencio da Luz, et al.
Published: (2022-01-01)

African trypanosomes
by: Mathieu Cayla, et al.
Published: (2019-04-01)

Isolation and Antitrypanosomal Characterization of Furoquinoline and Oxylipin from <i>Zanthoxylum zanthoxyloides</i>
by: Aboagye Kwarteng Dofuor, et al.
Published: (2020-12-01)

Designing Antitrypanosomal and Antileishmanial BODIPY Derivatives: A Computational and In Vitro Assessment
by: Raquel C. R. Gonçalves, et al.
Published: (2024-04-01)

<i>Salvia officinalis</i> L.: Antitrypanosomal Activity and Active Constituents against <i>Trypanosoma brucei rhodesiense</i>
by: Núria Llurba Montesino, et al.
Published: (2021-05-01)

2-(Nitroaryl)-5-Substituted-1,3,4-Thiadiazole Derivatives with Antiprotozoal Activities: In Vitro and In Vivo Study
by: Alireza Mousavi, et al.
Published: (2022-08-01)

African animal trypanocide resistance: A systematic review and meta-analysis
by: Keneth Iceland Kasozi, et al.
Published: (2023-01-01)

Temporal and Wash-Out Studies Identify Medicines for Malaria Venture Pathogen Box Compounds with Fast-Acting Activity against Both <i>Trypanosoma cruzi</i> and <i>Trypanosoma brucei</i>
by: Melissa L. Sykes, et al.
Published: (2022-06-01)

The Activity of Red Nigerian Propolis and Some of Its Components against <i>Trypanosoma brucei</i> and <i>Trypanosoma congolense</i>
by: Samya S. Alenezi, et al.
Published: (2023-01-01)

Evaluation of the Antitrypanosomal Activity of the Crude Extracts of Uvaria Ovata: In vitro and In silico Approach
by: Mary Anti Chama, et al.
Published: (2024-06-01)

Trypanocidal activity of organotin chlorides on Trypanosoma brucei-infected mice
by: Shuaibu M.N., et al.
Published: (2000-03-01)

Enolase Inhibitors as Early Lead Therapeutics against <i>Trypanosoma brucei</i>
by: Colm P. Roster, et al.
Published: (2023-10-01)

EUCALYPTUS OIL NANOEMULSION: EVALUATION OF IN VITRO ACTIVITY AGAINST TRYPANOSOMA BRUCEI
by: Emmanuel Maduabuchi Uronnachi, et al.
Published: (2024-12-01)

Evaluating the influence of trypanosomiasis on murine model using Corchorus olitorius leaf extract as a trypanocidal agent
by: Madaki Fatima M., et al.
Published: (2024-01-01)

Synthesis and Evaluation of Marine-Inspired Compounds Result in Hybrids with Antitrypanosomal and Antileishmanial Activities
by: Diogo Teixeira Carvalho, et al.
Published: (2023-10-01)

Variable Surface Glycoprotein from <i>Trypanosoma brucei</i> Undergoes Cleavage by Matrix Metalloproteinases: An in silico Approach
by: Cláudia Jassica Gonçalves Moreno, et al.
Published: (2019-10-01)

Activité thérapeutique et prophylactique de la combinaison Berenil<sup>R</sup> et DL-alpha-difluorométhylornithine (DFMO<sup>R</sup>) contre l’infection à <em>Trypanosoma brucei brucei</em> chez la souris
by: P.A. Onyeyili, et al.
Published: (1991-04-01)

Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream <i>Trypanosoma brucei</i>
by: Cecilia Ortíz, et al.
Published: (2021-01-01)

Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme
by: Alcione Silva de Carvalho, et al.
Published: (2014-06-01)

<i>Garcinia kola</i> Nuts: A Molecular Cocktail for Skin Care
by: Durand Dah-Nouvlessounon, et al.
Published: (2025-09-01)

Molecular Evidence of a Trypanosoma brucei gambiense Sylvatic Cycle in the Human African Trypanosomiasis Foci of Equatorial Guinea
by: Carlos eCordon-Obras, et al.
Published: (2015-07-01)

Novel Cytoskeleton-Associated Proteins in <i>Trypanosoma brucei</i> Are Essential for Cell Morphogenesis and Cytokinesis
by: Marina Schock, et al.
Published: (2021-10-01)

Compétence vectorielle des lignées Bobo-Dioulasso et Maisons-Alfort de <em>Glossina palpalis gambiensis</em> Vanderplank 1949 infectées simultanément par <em>Trypanosoma brucei brucei</em> EATRO 1125
by: J.M. Kazadi, et al.
Published: (1998-04-01)

In Vivo Efficacy of SQ109 against <i>Leishmania donovani</i>, <i>Trypanosoma</i> spp. and <i>Toxoplasma gondii</i> and In Vitro Activity of SQ109 Metabolites
by: Kyung-Hwa Baek, et al.
Published: (2022-03-01)

Genome-Wide Screening for Pathogenic Proteins and microRNAs Associated with Parasite–Host Interactions in <i>Trypanosoma brucei</i>
by: Zhiyuan Yang, et al.
Published: (2022-10-01)

In Silico and In Vitro Search for Dual Inhibitors of the <i>Trypanosoma brucei</i> and <i>Leishmania major</i> Pteridine Reductase 1 and Dihydrofolate Reductase
by: Katharina Possart, et al.
Published: (2023-11-01)

In-Vitro Antagonistic Characteristics of Crude Aqueous and Methanolic Extracts of Garcinia kola (Heckel) Seeds against Some Vibrio Bacteria
by: Anthony I. Okoh, et al.
Published: (2011-03-01)

An X-Domain Phosphoinositide Phospholipase C (PI-PLC-like) of <i>Trypanosoma brucei</i> Has a Surface Localization and Is Essential for Proliferation
by: Núria W. Negrão, et al.
Published: (2023-02-01)

Effet du moment de la stimulation antigénique sur le déroulement de la parasitémie et immunodépression consécutive lors d’une infection expérimentale à <em>Trypanosoma brucei</em>
by: M.M. Ikeme, et al.
Published: (1990-03-01)

Garcinia kola: A Scoping Review of its Benefits in Cardiometabolic Health
by: Kasimu Ghandi Ibrahim1,2,3*, Kehinde Ahmad Adeshina1,4, and Amina Yusuf Jega 5
Published: (2024-07-01)

Exploring grafting to propagate and conserve Garcinia kola a vulnerable species in Côte d’Ivoire
by: Jonas Patrick DAO, et al.
Published: (2025-05-01)

Assessment of Antimicrobial Effect of Alcohol and Aqueous Extracts of <i>Garcinia kola </i>on <i>Staphylococcus aureus</i>, Bacillus cereus, Escherichia coli</i> and<i> Klebsiella pneumonia</i>
by: A. Banso, et al.
Published: (2020-10-01)

Activity of Compounds from Temperate Propolis against <i>Trypanosoma brucei</i> and <i>Leishmania mexicana</i>
by: Adullah Alotaibi, et al.
Published: (2021-06-01)