Application experience of extracorporeal photopheresis for treatment of acute “graft-versus-host” disease after allogeneic hematopoietic stem cell transplantation

• Published in: Онкогематология
• Main Authors: A. V. Kozlov, T. A. Bykova, I. I. Kulagina, S. N. Bondarenko, E. V. Semenova, l. S. Zubarovskaya, B. V. Afanasyev
• Format: Article
• Language: Russian
• Published: ABV-press 2014-07-01
• Subjects: allogeneic hematopoietic stem cells transplantation; extracorporeal photopheresis; combined immunosuppressive therapy; acute “graft-versus-host” disease
• Online Access: https://oncohematology.abvpress.ru/ongm/article/view/23
• ISSN: 1818-8346; 2413-4023

Extracorporeal photopheresis (ECP) has been used as a component of combined immunosuppressive therapy in 53 patients with steroid-refractoryacute “graft-versus-host” disease. Overall response was observed in 35 patients (66 %; 95 % CI 52.6–77.3): complete response (CR) in 15 pts (28.3 %; 95 % CI 18–41.6) and partial response (PR) in 20 pts (37.7 %; 95 % CI 25.9–51.2). 3-year OS was 39 % in patients with clinical response (CR or PR); in the absence of clinical response OS was 8 % during the first year (p < 0.0001). Median methylprednisolone dose before ECP was 2 mg/kg/day, and at the end of ECP course – 0.7 mg/kg/day (p < 0.0001).