Bartter Syndrome Presenting with Metabolic Alkalosis: A Case Series
Bartter Syndrome (BS) is a rare, inherited renal tubulopathy characterised by hypokalaemic, hypochloraemic metabolic alkalosis. Children present with the complaint of polyuria, dehydration, failure to thrive and normal blood pressure despite hyperreninemia and hyperaldosteronism. This is a series...
| Published in: | Journal of Clinical and Diagnostic Research |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2023-07-01
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| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/18178/62148_CE[Ra1]_F(IS)_PF1(AKA_SS)_PN(KM).pdf |
| Summary: | Bartter Syndrome (BS) is a rare, inherited renal tubulopathy characterised by hypokalaemic, hypochloraemic metabolic alkalosis.
Children present with the complaint of polyuria, dehydration, failure to thrive and normal blood pressure despite hyperreninemia
and hyperaldosteronism. This is a series of eight children (2 months -1 years of age, 5 males and 3 females children) diagnosed with
BS. Mean age of onset was five months with male predominance. Most common presentation was failure to thrive and polyuria.
All children showed metabolic alkalosis with hyponatremia, hypokalemia and hypochloremia. Urinary losses of sodium, potassium
and chloride were noted in all the eight children. Diagnosis was based on clinical manifestation and electrolyte abnormalities.
All children were started on indomethacin and positive response was noted. On follow-up correction of electrolyte abnormalities
along with adequate weight gain was seen. Although, it is a rare disease requiring high index of suspicion, but with prompt clinical
diagnosis and early treatment, morbidity and mortality can be significantly reduced. |
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| ISSN: | 2249-782X 0973-709X |