CD10-Bound Human Mesenchymal Stem/Stromal Cell-Derived Small Extracellular Vesicles Possess Immunomodulatory Cargo and Maintain Cartilage Homeostasis under Inflammatory Conditions

The onset and progression of human inflammatory joint diseases are strongly associated with the activation of resident synovium/infrapatellar fat pad (IFP) pro-inflammatory and pain-transmitting signaling. We recently reported that intra-articularly injected IFP-derived mesenchymal stem/stromal cell...

Full description

Bibliographic Details
Published in:	Cells
Main Authors:	Dimitrios Kouroupis, Lee D. Kaplan, Johnny Huard, Thomas M. Best
Format:	Article
Language:	English
Published:	MDPI AG 2023-07-01
Subjects:	mesenchymal stem/stromal cells (MSC) synovium infrapatellar fat pad (IFP) CD10 (neprilysin) PRG4 (lubricin) small extracellular vesicles (sEVs)
Online Access:	https://www.mdpi.com/2073-4409/12/14/1824

Similar Items

Modification of Mesenchymal Stem/Stromal Cell-Derived Small Extracellular Vesicles by Calcitonin Gene Related Peptide (CGRP) Antagonist: Potential Implications for Inflammation and Pain Reversal
by: Kevin Liebmann, et al.
Published: (2024-03-01)

Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican
by: Jiapeng Xue, et al.
Published: (2020-07-01)

<i>Prg4</i> and Osteoarthritis: Functions, Regulatory Factors, and Treatment Strategies
by: Peng-Jie Fu, et al.
Published: (2025-03-01)

Engineered MSC‐sEVs as a Versatile Nanoplatform for Enhanced Osteoarthritis Treatment via Targeted Elimination of Senescent Chondrocytes and Maintenance of Cartilage Matrix Metabolic Homeostasis
by: Kai Feng, et al.
Published: (2025-02-01)

Mesenchymal stem cells-derived small extracellular vesicles alleviate diabetic retinopathy by delivering NEDD4
by: Fengtian Sun, et al.
Published: (2022-07-01)

Targeting CD44 Receptor Pathways in Degenerative Joint Diseases: Involvement of Proteoglycan-4 (PRG4)
by: Marwa M. Qadri
Published: (2023-10-01)

USP9X-enriched MSC-sEV inhibits LSEC angiogenesis in MASH mice by downregulating the IκBα/NF-κB/Ang-2 pathway
by: Yanjin Wang, et al.
Published: (2024-11-01)

Investigation of the Presence of Telocyte-like Cells in Human Patellar Fat Pad Tissue
by: Tanriverdi Gamze, et al.
Published: (2024-01-01)

Boundary mode frictional properties of engineered cartilaginous tissues
by: J P Gleghorn, et al.
Published: (2007-08-01)

Single-Cell RNA-Sequencing Identifies Infrapatellar Fat Pad Macrophage Polarization in Acute Synovitis/Fat Pad Fibrosis and Cell Therapy
by: Dimitrios Kouroupis, et al.
Published: (2021-10-01)

Small extracellular vesicles derived from mesenchymal stromal cells loaded with β-nicotinamide mononucleotide activate NAD+/SIRT3 signaling pathway-mediated mitochondrial autophagy to delay skin aging
by: Zixuan Sun, et al.
Published: (2025-07-01)

Culture Time Needed to Scale up Infrapatellar Fat Pad Derived Stem Cells for Cartilage Regeneration: A Systematic Review
by: Sam L. Francis, et al.
Published: (2020-07-01)

INFRAPATELLAR FAT PAD HAEMANGIOMA — CASE REPORT
by: Dzoleva-Tolevska Roza, et al.
Published: (2014-07-01)

Infrapatellar fat pad haemangioma: Case report
by: Dzoleva-Tolevska Roza, et al.
Published: (2014-07-01)

A method for isolating small extracellular vesicles from parenchymal tissues
by: Yanan Sun, et al.
Published: (2025-06-01)

The superficial zone of articular cartilage
by: Taku Saito
Published: (2022-05-01)

Comprehensive comparative analysis of infrapatellar fat pad morphologies in a longitudinal knee osteoarthritis exploratory study: new insights into its role as an independent prognostic marker
by: Jean-Pierre Pelletier, et al.
Published: (2025-04-01)

Lyophilized Small Extracellular Vesicles (sEVs) Derived from Human Adipose Stem Cells Maintain Efficacy to Promote Healing in Neuronal Injuries
by: Brianna Jones, et al.
Published: (2025-01-01)

Tropoelastin improves adhesion and migration of intra-articular injected infrapatellar fat pad MSCs and reduces osteoarthritis progression
by: Junjun Yang, et al.
Published: (2022-04-01)

An Assessment of Administration Route on MSC-sEV Therapeutic Efficacy
by: Bin Zhang, et al.
Published: (2024-05-01)

The clinical efficacy of arthroscopic therapy with knee infrapatellar fat pad cell concentrates in treating knee cartilage lesion: a prospective, randomized, and controlled study
by: Yiqin Zhou, et al.
Published: (2021-01-01)

Extracellular Vesicles in Infrapatellar Fat Pad from Osteoarthritis Patients Impair Cartilage Metabolism and Induce Senescence
by: Yumei Cao, et al.
Published: (2024-01-01)

A novel infrapatellar fat pad preservation technique in anterior cruciate ligament reconstruction reduces postoperative pain and cartilage damage: a retrospective study
by: Shilin Li, et al.
Published: (2025-08-01)

Circulating Small Extracellular Vesicles Involved in Systemic Regulation Respond to RGC Degeneration in Glaucoma
by: Tong Li, et al.
Published: (2024-08-01)

Effects on patellar chondromalacia of the size of the infrapatellar fat pad
by: Abuzer Uludag, et al.
Published: (2019-03-01)

The equine patellar ligaments and the infrapatellar fat pad – a microanatomical study
by: Cathrine Taule Fjordbakk, et al.
Published: (2023-01-01)

Dimensional changes of Hoffa’s fat pad related to aging: evaluation by MRI
by: Valentina Testini, et al.
Published: (2024-01-01)

Peptide-modified chondroitin sulfate reduces coefficient of friction at articular cartilage surface
by: Celina Twitchell, et al.
Published: (2020-11-01)

A IMPLEMENTAÇÃO DO PRONATEC NO IFPE
by: André Luís Pereira
Published: (2018-06-01)

Extracellular Vesicles in Therapeutics: A Comprehensive Review on Applications, Challenges, and Clinical Progress
by: Jiyoung Goo, et al.
Published: (2024-02-01)

Therapeutic Efficacy of Mesenchymal Stem/Stromal Cell Small Extracellular Vesicles in Alleviating Arthritic Progression by Restoring Macrophage Balance
by: Bin Zhang, et al.
Published: (2023-10-01)

A pH-responsive PEG coating strategy for enhancing the enrichment of small extracellular vesicles towards disease regions with acidic microenvironment
by: Jianwei Zhao, et al.
Published: (2025-06-01)

Bioregulation of lubricin expression by growth factors and cytokines
by: A R C Jones, et al.
Published: (2007-03-01)

Long-term effects of infrapatellar fat pad SVF infiltration in knee osteoarthritis management: A prospective cohort study
by: Klaus Werner Labarre, et al.
Published: (2025-03-01)

Enhancing Immunomodulatory Function of Mesenchymal Stromal Cells by Hydrogel Encapsulation
by: Hui-Yun Cheng, et al.
Published: (2024-01-01)

Anti-hypertrophic effect of synovium-derived stromal cells on costal chondrocytes promotes cartilage repairs
by: Yiyang Ma, et al.
Published: (2022-01-01)

A Hoffa’s fat pad lipoma mimicked patellar subluxation.
by: Kamel REMITA, et al.
Published: (2024-06-01)

Infrapatellar fat pad as a source of biomarkers and therapeutic target for knee osteoarthritis
by: Betzabeth Pereira Herrera, et al.
Published: (2025-04-01)

Adipose Tissue-Derived Mesenchymal Stem Cells as a Potential Restorative Treatment for Cartilage Defects: A PRISMA Review and Meta-Analysis
by: Henry Yue-Hong Meng, et al.
Published: (2021-12-01)

3D Solar Irradiance Model for Non-Uniform Shading Environments Using Shading (Aperture) Matrix Enhanced by Local Coordinate System
by: Kenji Araki, et al.
Published: (2023-05-01)