NOS3 rs3918188C>A is associated with susceptibility to resistant hypertension while CES1 genetic variation was not associated with resistant hypertension among South Africans

IntroductionGenetic variation in genes coding for enzymes metabolising antihypertensive drugs, may affect the efficacy of angiotensin converting enzyme (ACE) inhibitors such as enalapril, potentially leading to resistant hypertension (RHTN). We set out to evaluate the contribution of genetic variati...

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Bibliographic Details
Published in:	Frontiers in Genetics
Main Authors:	Jonathan N. Katsukunya, Revina Naicker, Nyarai D. Soko, Dirk Blom, Phumla Sinxadi, Emile R. Chimusa, Brian Rayner, Erika Jones, Collet Dandara
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Subjects:	CES1 NOS3 pharmacogenomics hypertension Africans ACE inhibitors
Online Access:	https://www.frontiersin.org/articles/10.3389/fgene.2025.1608423/full

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