Flavonoids from <i>Ficus pandurate</i> var. <i>angustifolia</i> W.C. Cheng Restore Cognitive Impairment and Regulate the Gut Microbiota in Sleep-Deprived Mice

• الحاوية / القاعدة: Foods
• المؤلفون الرئيسيون: Haochen Dai, Songmei Luo, Xin Zhang
• التنسيق: مقال
• اللغة: الإنجليزية
• منشور في: MDPI AG 2025-08-01
• الموضوعات: <i>Ficus pandurata</i> var. <i>angustifolia</i> W.C. Cheng; flavonoids; gut microbiota; inflammation; cognition
• الوصول للمادة أونلاين: https://www.mdpi.com/2304-8158/14/16/2888

Sleep deprivation (SD) induces cognitive impairment associated with gut microbiota dysbiosis, making it crucial to explore natural remedies targeting the microbiota–gut–brain axis. This study aims to investigate whether <i>Ficus pandurata</i> var. <i>angustifolia</i> W.C. Cheng (a traditional medicine–food plant rich in flavonoids) can mitigate cognitive impairment caused by SD by modulating the gut microbiota. The sleep-deprived mouse model was established using the multiple platform water environment method. This study investigated the effects of <i>F. pandurata</i> var. <i>angustifolia</i> flavonoids (FCFs) via behavioral tests, 16S rRNA sequencing, and biochemical analyses to assess cognitive function, gut microbiota, and related pathways. FCF alleviated SD-induced cognitive deficits, reversed gut microbiota dysbiosis (increased beneficial bacteria like <i>Lactobacillus</i>, reduced harmful ones like <i>Desulfovibrio</i>), promoted short-chain fatty acids production, improved colonic histopathology and intestinal barrier function, reduced serum lipopolysaccharide, inhibited glial cell activation and TLR4/NF-κB signaling, and regulated neurotransmitters. In conclusion, FCF ameliorates SD-induced cognitive impairment through regulating gut microbiota, enhancing intestinal barrier, and suppressing neuroinflammation via the microbiota–gut–brain axis, providing a theoretical basis for its application.