Interferon-Stimulated SAMHD1 Restricts Hepatitis C Virus Replication

Human SAMHD1 is an IFN-induced dNTP triphosphatase that is able to restrict HIV-1 replication, whereas its role in innate immunity against virus infection remains largely unexplored. In this work, we provided evidence that SAMHD1 functions as an anti-HCV host factor. We found that overexpression of...

Full description

Bibliographic Details
Published in:	Proceedings
Main Authors:	Ni An, Jianyuan Zhao, Shan Cen
Format:	Article
Language:	English
Published:	MDPI AG 2020-06-01
Subjects:	SAMHD1 HCV lipid droplets
Online Access:	https://www.mdpi.com/2504-3900/50/1/42

Similar Items

SAMHD1 Enhances Chikungunya and Zika Virus Replication in Human Skin Fibroblasts
by: Sineewanlaya Wichit
Published: (2020-06-01)

The Chemokine CCL5 Inhibits the Replication of Influenza A Virus Through SAMHD1 Modulation
by: Thauane Silva, et al.
Published: (2021-08-01)

Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection
by: Timothy Plitnik, et al.
Published: (2018-12-01)

Identification and characterization of naturally occurring splice variants of SAMHD1
by: Welbourn Sarah, et al.
Published: (2012-10-01)

Lipid Droplets Accumulation during Hepatitis C Virus Infection in Cell-Culture Varies among Genotype 1–3 Strains and Does Not Correlate with Virus Replication
by: Andrea Galli, et al.
Published: (2021-02-01)

PNP inhibitors selectively kill cancer cells lacking SAMHD1
by: Tamara Davenne, et al.
Published: (2020-11-01)

Impaired influenza A virus replication by the host restriction factor SAMHD1 which inhibited by PA-mediated dephosphorylation of the host transcription factor IRF3
by: Zhilei Zhao, et al.
Published: (2024-01-01)

SAMHD1 Is a Modulator of Nucleos(t)ide Analogues’ Efficacy
by: Ifeanyi Ezeonwumelu, et al.
Published: (2020-06-01)

The SAMHD1-MX2 axis restricts HIV-1 infection at postviral DNA synthesis
by: Haoran Guo, et al.
Published: (2024-07-01)

SAMHD1 Functions and Human Diseases
by: Si’Ana A. Coggins, et al.
Published: (2020-03-01)

SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity
by: Christopher H. Mauney, et al.
Published: (2018-04-01)

SAMHD1 … and Viral Ways around It
by: Janina Deutschmann, et al.
Published: (2021-03-01)

SAMHD1 is a barrier to antimetabolite-based cancer therapies
by: Sean G. Rudd, et al.
Published: (2017-03-01)

Hepatitis C Virus Uses Host Lipids to Its Own Advantage
by: Malgorzata Sidorkiewicz
Published: (2021-04-01)

Mechanism of hepatitis B virus X mediating SAMHD1 degradation to promote proliferation of hepatoma cells through AKT/p27 pathway
by: ZHENG Xiaochuan, et al.
Published: (2021-05-01)

dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction
by: Pak-Hin Hinson Cheung, et al.
Published: (2025-05-01)

Deubiquitinase USP37 enhances the anti-HIV-2/SIV ability of the host restriction factor SAMHD1
by: Wenzhe Cui, et al.
Published: (2025-01-01)

PIAS1 Regulates Hepatitis C Virus-Induced Lipid Droplet Accumulation by Controlling Septin 9 and Microtubule Filament Assembly
by: Abdellah Akil, et al.
Published: (2021-10-01)

Host SAMHD1 protein restricts endogenous reverse transcription of HIV-1 in nondividing macrophages
by: Bijan Mahboubi, et al.
Published: (2018-10-01)

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction, and cellular dNTP levels
by: Moritz Schüssler, et al.
Published: (2023-10-01)

Functional conservation and divergence of arabidopsis VENOSA4 and human SAMHD1 in DNA repair
by: Raquel Sarmiento-Mañús, et al.
Published: (2025-01-01)

Acetylation of SAMHD1 at lysine 580 is crucial for blocking HIV-1 infection
by: Angel Bulnes-Ramos, et al.
Published: (2024-09-01)

Deciphering lentiviral Vpr/Vpx determinants required for HUSH and SAMHD1 antagonism highlights the molecular plasticity of these evolutionary conflicts
by: Pauline Larrous, et al.
Published: (2025-05-01)

A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery
by: Ferdinand Roesch, et al.
Published: (2018-03-01)

Effect of NME2 and SAMHD1 genetic polymorphisms involved in Ara-C metabolism on the response to induction chemotherapy in adult acute myeloid leukemia
by: Lamiaa Ahmed Fouad, et al.
Published: (2025-04-01)

SAMHD1 Phosphorylation at T592 Regulates Cellular Localization and S-phase Progression
by: Stephanie Batalis, et al.
Published: (2021-08-01)

Targeting SAMHD1: To overcome multiple anti-cancer drugs resistance in hematological malignancies
by: Tao Wang, et al.
Published: (2023-05-01)

The SAMHD1 rs6029941 (A/G) Polymorphism Seems to Influence the HTLV-1 Proviral Load and IFN-Alpha Levels
by: Maria Alice Freitas Queiroz, et al.
Published: (2020-05-01)

PIAS1 potentiates the anti-EBV activity of SAMHD1 through SUMOylation
by: Farjana Saiada, et al.
Published: (2021-07-01)

SAMHD1 expression modulates innate immune activation and correlates with ovarian cancer prognosis
by: Lucía Gutiérrez-Chamorro, et al.
Published: (2023-02-01)

Ribonucleotide reductase inhibitors suppress SAMHD1 ara‐CTPase activity enhancing cytarabine efficacy
by: Sean G Rudd, et al.
Published: (2020-01-01)

Hypoxia-inducible factor 2 triggers the production of highly infectious native-like hepatitis C virus particles
by: Mathilde Couteaudier, et al.
Published: (2025-06-01)

SAMHD1 deficiency enhances macrophage-mediated clearance of Salmonella Typhimurium via NF-κB activation in zebrafish
by: Alicia Martínez-López, et al.
Published: (2025-04-01)

Deciphering the role of SAMHD1 in endometrial cancer progression
by: Ping Qiang, et al.
Published: (2024-10-01)

Modulation of Lipid Droplet Metabolism—A Potential Target for Therapeutic Intervention in Flaviviridae Infections
by: Jingshu Zhang, et al.
Published: (2017-11-01)

The avengers: SAMHD1 cooperates with MX2/MxB to defend against HIV-1
by: Zhi Wan, et al.
Published: (2024-10-01)

Characterization of a mutant samhd1 zebrafish model implicates dysregulation of cholesterol biosynthesis in Aicardi-Goutières syndrome
by: Sarah E. Withers, et al.
Published: (2023-03-01)

Molecular Events Occurring in Lipophagy and Its Regulation in Flaviviridae Infection
by: Keke Wu, et al.
Published: (2021-05-01)

SAMHD1 enhances HIV-1-induced apoptosis in monocytic cells via the mitochondrial pathway
by: Hua Yang, et al.
Published: (2025-07-01)

Regulating Action of in Vitro Hepatitis C Virus Infection on Interferon-Induced Interferon Stimulating Genes in Murine Macrophages
by: Dolgorsuren Sandagdorj, et al.
Published: (2018-03-01)