Effect of ferulic acid on Myocardial Ischemia/Reperfusion Injury In Male Mice.

• 出版年: Kufa Journal for Veterinary Medical Sciences
• 主要な著者: Bassim I. Mohammad AL-Sheibani, Najah Raiesh Hadi, Najwan Abdulameer Atia, Fadhil Ghaly. Yousif
• フォーマット: 論文
• 言語: 英語
• 出版事項: Faculty of Veterinary Medicine, University of Kufa 2014-12-01
• 主題: Dimethylsulfoxide (DMSO); Ferulic acid (FA); Ischemia-reperfusion (I/R); multiple organ dysfunction syndrome (MODS); systemic inflammatory response syndrome (SIRS); left anterior descending (LAD)
• オンライン･アクセス: https://journal.uokufa.edu.iq/index.php/kjvs/article/view/4187
• ISSN: 2077-9798; 2959-8478

Myocardial ischemia–reperfusion represents a clinically relevant problem associated with thrombolysis, angioplasty and coronary bypass surgery. Injury of myocardium due to ischemia–reperfusion includes cardiac contractile dysfunction, arrhythmias as well as irreversible myocytes damage.                                                               A total of 24 Swiss albino adult male mice were randomized into 4 equal groups. Group (1) sham group; Group (2) control group; Group (3) control vehicle (DMSO) group; Group (4) Ferulic acid treated group. Results of this study showed that levels of myocardial IL-6, were increased (p<0.001) in the control group. Histologically, all mice  in control group showed significant cardiac injury (p<0.001). Ferulic acid   significantly counteract the increase in myocardium level of IL-6 (P < 0.001). Histological analysis revealed that ferulic acid   markedly reduced (P < 0.001) the severity of cardiac injury in the mice underwent LAD ligation procedure. Keywords: Ischemia-reperfusion (I/R) ,systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS) ,  Ferulic acid (FA), left anterior descending (LAD), Dimethylsulfoxide (DMSO).