Identification of pyroptosis-related subtypes and comprehensive analysis of characteristics of the tumor microenvironment infiltration in clear cell renal cell carcinoma

• Published in: Scientific Reports
• Main Authors: Jiayi Zeng, Ping Zhu, Yanlin Tang, Changzheng Zhang, Chujin Ye, Shouyu Cheng, Kaiwen Tian, Bowen Yang, Weinan Zeng, Yanjun Liu, Zhiyong Xian, Yuming Yu
• Format: Article
• Language: English
• Published: Nature Portfolio 2023-09-01
• Online Access: https://doi.org/10.1038/s41598-023-43023-y

Abstract Pyroptosis is a kind of programmed cell death triggered by the inflammasome. Growing evidence has revealed the crucial utility of pyroptosis in tumors. However, the potential mechanism of pyroptosis in clear cell renal cell carcinoma (ccRCC) is still unclear. In this research, we systematically analyze the genetic and transcriptional alterations of pyroptosis-related genes (PRGs) in ccRCC, identify pyroptosis-related subtypes, analyze the clinical and microenvironmental differences among different subtypes, develop a corresponding prognostic model to predict the prognosis of patients, and interpret the effect of pyroptosis on ccRCC microenvironment. This study provides a new perspective for a comprehensive understanding of the role of pyroptosis in ccRCC and its impact on the immune microenvironment, and a reliable scoring system was established to predict patients’ prognosis.