The Emerging World of JAK Inhibitors

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The Janus Kinase inhibitors are a new emerging class of small molecules. These target the Janus Kinase proteins located on the cell membrane. Janus Kinase proteins regulate the cellular transcription of several proteins and act as mediators in several cytokine pathways. Dysregulation in these cytok...

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Bibliographic Details
Published in:Nepal Journal of Dermatology, Venereology & Leprology
Main Author: Shraddha Uprety
Format: Article
Language:English
Published: Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON) 2024-10-01
Subjects:
Alopecia areata
Atopic Dermatitis
JAK inhibitors
Lichen Planus
Pruritus
Psoriasis
Online Access:https://www.nepjol.info/index.php/NJDVL/article/view/68527
Description
Summary:The Janus Kinase inhibitors are a new emerging class of small molecules. These target the Janus Kinase proteins located on the cell membrane. Janus Kinase proteins regulate the cellular transcription of several proteins and act as mediators in several cytokine pathways. Dysregulation in these cytokine pathways is responsible for disorders like alopecia areata, psoriasis, vitiligo, lichen planus, and more in dermatology. Contrary to the injectable biologics, these Janus kinase inhibitors can be taken per oral route and have greater patient acceptability. In this review, we seek to discuss the various indications of Janus Kinase inhibitors and their side effects. We also strive to discuss the monitoring for this class of drugs.
ISSN:2091-0231
2091-167X

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