Pharmacological inactivation of the prion protein by targeting a folding intermediate

Spagnolli, Massignan, Astolfi et al. design a new drug discovery approach, termed Pharmacological Protein Inactivation by Folding Intermediate Targeting, in which folding intermediates of disease-causing proteins are targeted. They test it on the cellular prion protein, identifying ligands stabilizi...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Communications Biology
المؤلفون الرئيسيون: Giovanni Spagnolli, Tania Massignan, Andrea Astolfi, Silvia Biggi, Marta Rigoli, Paolo Brunelli, Michela Libergoli, Alan Ianeselli, Simone Orioli, Alberto Boldrini, Luca Terruzzi, Valerio Bonaldo, Giulia Maietta, Nuria L. Lorenzo, Leticia C. Fernandez, Yaiza B. Codeseira, Laura Tosatto, Luise Linsenmeier, Beatrice Vignoli, Gianluca Petris, Dino Gasparotto, Maria Pennuto, Graziano Guella, Marco Canossa, Hermann C. Altmeppen, Graziano Lolli, Stefano Biressi, Manuel M. Pastor, Jesús R. Requena, Ines Mancini, Maria L. Barreca, Pietro Faccioli, Emiliano Biasini
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Nature Portfolio 2021-01-01
الوصول للمادة أونلاين:https://doi.org/10.1038/s42003-020-01585-x

مواد مشابهة

مواد مشابهة