Loss of the SWI/SNF-ATPase subunit members SMARCF1 (ARID1A), SMARCA2 (BRM), SMARCA4 (BRG1) and SMARCB1 (INI1) in oesophageal adenocarcinoma

Abstract Background The SWI/SNF complex is an important chromatin remodeler, commonly dysregulated in cancer, with an estimated mutation frequency of 20%. ARID1A is the most frequently mutated subunit gene. Almost nothing is known about the other familiar members of the SWI/SNF complexes, SMARCA2 (B...

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Bibliographic Details
Published in:	BMC Cancer
Main Authors:	Simon Schallenberg, Julian Bork, Ahlem Essakly, Hakan Alakus, Reinhard Buettner, Axel M. Hillmer, Christiane Bruns, Wolfgang Schroeder, Thomas Zander, Heike Loeser, Florian Gebauer, Alexander Quaas
Format:	Article
Language:	English
Published:	BMC 2020-01-01
Subjects:	SWI/SNF-complex Loss-of-function Oesophageal adenocarcinoma TP53 loss Heterogeneity
Online Access:	https://doi.org/10.1186/s12885-019-6425-3

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