Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations

Abstract Given that lumbar disc herniation (LDH) is a prevalent spinal condition that causes significant individual suffering and societal costs, the genetic basis of LDH has received relatively little research. Our aim is to increase understanding of the genetic factors influencing LDH. We perform...

Full description

Bibliographic Details
Published in:	Nature Communications
Main Authors:	Ville Salo, Juhani Määttä, Eeva Sliz, FinnGen, Ene Reimann, Reedik Mägi, Estonian Biobank Research Team, Kadri Reis, Abdelrahman G. Elhanas, Anu Reigo, Priit Palta, Tõnu Esko, Jaro Karppinen, Johannes Kettunen
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-11-01
Online Access:	https://doi.org/10.1038/s41467-024-53467-z

Similar Items

Genetic architecture of lumbar spinal stenosis
by: Ville Salo, et al.
Published: (2026-04-01)

Pathway level metabolomics analysis identifies carbon metabolism as a key factor of incident hypertension in the Estonian Biobank
by: Liis Hiie, et al.
Published: (2025-03-01)

Disentangling the consequences of type 2 diabetes on targeted metabolite profiles using causal inference and interaction QTL analyses.
by: Ozvan Bocher, et al.
Published: (2024-12-01)

Genetic determinants of plasma protein levels in the Estonian population
by: Anette Kalnapenkis, et al.
Published: (2024-04-01)

Genome-wide association study identifies five risk loci for pernicious anemia
by: Triin Laisk, et al.
Published: (2021-06-01)

Leveraging large-scale multi-omics evidences to identify therapeutic targets from genome-wide association studies
by: Samuel Lessard, et al.
Published: (2024-11-01)

Comorbidities confound metabolomics studies of human disease
by: Madis Jaagura, et al.
Published: (2024-10-01)

Self- and informant-reported personality traits and vaccination against COVID-19.
by: Kadri Arumäe, et al.
Published: (2024-01-01)

Polygenic risk scores as a marker for epilepsy risk across lifetime and after unspecified seizure events
by: Henrike O. Heyne, et al.
Published: (2024-07-01)

Genome-wide association study of pulpal and apical diseases
by: Aino Salminen, et al.
Published: (2025-07-01)

The role of co-occurring insomnia and mental distress in the association between lumbar disc degeneration and low back pain related disability
by: Teija Mertimo, et al.
Published: (2023-04-01)

Modeling the Multidimensional Predictors of Multisite Musculoskeletal Pain Across Adulthood—A Generalized Estimating Equations Approach
by: Ville-Heikki Ahlholm, et al.
Published: (2021-08-01)

Association of accelerometer-measured physical activity, back static muscular endurance and abdominal obesity with radicular pain and non-specific low back pain
by: Munkh-Erdene Bayartai, et al.
Published: (2023-05-01)

Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification
by: Kristi Läll, et al.
Published: (2019-06-01)

Proteomic analysis of serum in a population‐based cohort did not reveal a biomarker for Modic changes
by: Friederike Schulze, et al.
Published: (2024-09-01)

Genome-wide screen of otosclerosis in population biobanks: 27 loci and shared associations with skeletal structure
by: Joel T. Rämö, et al.
Published: (2023-01-01)

Haplotype phasing and inheritance of copy number variants in nuclear families.
by: Priit Palta, et al.
Published: (2015-01-01)

Rare copy-number variants as modulators of common disease susceptibility
by: Chiara Auwerx, et al.
Published: (2024-01-01)

Plasma Metabolic Outliers Identified in Estonian Human Knockouts
by: Ketian Yu, et al.
Published: (2025-05-01)

Genome-wide association study of obstructive sleep apnoea in the Million Veteran Program uncovers genetic heterogeneity by sexResearch in context
by: Tamar Sofer, et al.
Published: (2023-04-01)

Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons.
by: Krista Fischer, et al.
Published: (2014-02-01)

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis
by: Sanni E. Ruotsalainen, et al.
Published: (2022-08-01)

Wear resistance of HVOF sprayed coatings from mechanically activated thermally synthesized Cr3C2–Ni spray powder; pp. 101–106
by: Heikki Sarjas, et al.
Published: (2016-02-01)

High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene
by: Fedik Rahimov, et al.
Published: (2024-11-01)

HLA allele-calling using multi-ancestry whole-exome sequencing from the UK Biobank identifies 129 novel associations in 11 autoimmune diseases
by: Guillaume Butler-Laporte, et al.
Published: (2023-11-01)

SCGB1D2 inhibits growth of Borrelia burgdorferi and affects susceptibility to Lyme disease
by: Satu Strausz, et al.
Published: (2024-03-01)

Young people as agents in regional shrinkage – commentary to Syssner
by: Marika Kettunen, et al.
Published: (2023-01-01)

Effectiveness of a classification-based approach to low back pain in primary care – a benchmarking controlled trial
by: Anna Sofia Simula, et al.
Published: (2024-04-01)

Trees in Positive Entropy Subshifts
by: Ville Salo
Published: (2021-04-01)

On Nilpotency and Asymptotic Nilpotency of Cellular Automata
by: Ville Salo
Published: (2012-08-01)

Common clinical blood and urine biomarkers for ischemic stroke: an Estonian Electronic Health Records database study
by: Siim Kurvits, et al.
Published: (2023-03-01)

Changes in the Early Holocene lacustrine environment inferred from the subfossil ostracod record in the Varangu section, northern Estonia
by: Tõnu Meidla, et al.
Published: (2010-09-01)

Effects of data transformation and model selection on feature importance in microbiome classification data
by: Zuzanna Karwowska, et al.
Published: (2025-01-01)

A novel framework for assessing causal effect of microbiome on health: long-term antibiotic usage as an instrument
by: Nele Taba, et al.
Published: (2025-12-01)

Chlorinated hydrocarbons in beef, cow liver and milk products and total mercury in cow liver
by: Hilkka Tyllinen, et al.
Published: (1975-12-01)

Upward transtentorial herniation
by: Nidal B. Omar, et al.
Published: (2020-12-01)

Paraperitoneal herniation of the ureter
by: Bhamidipaty Kanaka Durgaprasad, MD, et al.
Published: (2021-11-01)

Intercostal Lung Herniation
by: David Manthey, et al.
Published: (2017-03-01)

Systematic evaluation of NIPT aneuploidy detection software tools with clinically validated NIPT samples.
by: Priit Paluoja, et al.
Published: (2021-12-01)

Chemical composition of red wines made from hybrid grape and common grape (Vitis vinifera L.) cultivars; pp. 444–453
by: Priit Pedastsaar, et al.
Published: (2014-11-01)