Lymphoblastic transformation of myelodysplastic syndrome
Mielodysplastic syndromes (MDS) are clonal disorders of the hemopoietic stem cell. About one third of the cases terminate in an acute leukemia, usually acute myeloblastic leukemia. However, few cases of transformation into acute lymphoblastic leukemia (ALL) have been described. We present a case of...
| الحاوية / القاعدة: | São Paulo Medical Journal |
|---|---|
| المؤلفون الرئيسيون: | , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
Associação Paulista de Medicina
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000400009&lng=en&tlng=en |
| _version_ | 1852720059722498048 |
|---|---|
| author | Carmen Silvia Passos Lima Cármino Antonio de Souza Izilda Aparecida Cardinalli Irene Lorand-Metze |
| author_facet | Carmen Silvia Passos Lima Cármino Antonio de Souza Izilda Aparecida Cardinalli Irene Lorand-Metze |
| author_sort | Carmen Silvia Passos Lima |
| collection | DOAJ |
| container_title | São Paulo Medical Journal |
| description | Mielodysplastic syndromes (MDS) are clonal disorders of the hemopoietic stem cell. About one third of the cases terminate in an acute leukemia, usually acute myeloblastic leukemia. However, few cases of transformation into acute lymphoblastic leukemia (ALL) have been described. We present a case of refractory anemia that transformed into ALL two months after diagnosis and was successfully treated with conventional chemotherapy. Two years later a hyperfibrotic form of MDS was detected in the patient, that soon after terminated in acute megakaryoblastic leukemia. The course of MDS in the present case provides evidence that MDS can involve a pluripotent stem cell, presenting clonal evolution, documented by successive changes in its clinical and hematological features. |
| format | Article |
| id | doaj-art-e1245e3818aa48ba91d83cc7409b7e29 |
| institution | Directory of Open Access Journals |
| issn | 1806-9460 |
| language | English |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| spelling | doaj-art-e1245e3818aa48ba91d83cc7409b7e292025-08-19T21:12:54ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-946011541508151210.1590/S1516-31801997000400009S1516-31801997000400009Lymphoblastic transformation of myelodysplastic syndromeCarmen Silvia Passos Lima0Cármino Antonio de Souza1Izilda Aparecida Cardinalli2Irene Lorand-Metze3Hematology and Hemotherapy CenterHematology and Hemotherapy CenterHematology and Hemotherapy CenterHematology and Hemotherapy CenterMielodysplastic syndromes (MDS) are clonal disorders of the hemopoietic stem cell. About one third of the cases terminate in an acute leukemia, usually acute myeloblastic leukemia. However, few cases of transformation into acute lymphoblastic leukemia (ALL) have been described. We present a case of refractory anemia that transformed into ALL two months after diagnosis and was successfully treated with conventional chemotherapy. Two years later a hyperfibrotic form of MDS was detected in the patient, that soon after terminated in acute megakaryoblastic leukemia. The course of MDS in the present case provides evidence that MDS can involve a pluripotent stem cell, presenting clonal evolution, documented by successive changes in its clinical and hematological features.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000400009&lng=en&tlng=enMyelodysplastic syndromeAcute lymphoblastic leukemiaClonal evolution |
| spellingShingle | Carmen Silvia Passos Lima Cármino Antonio de Souza Izilda Aparecida Cardinalli Irene Lorand-Metze Lymphoblastic transformation of myelodysplastic syndrome Myelodysplastic syndrome Acute lymphoblastic leukemia Clonal evolution |
| title | Lymphoblastic transformation of myelodysplastic syndrome |
| title_full | Lymphoblastic transformation of myelodysplastic syndrome |
| title_fullStr | Lymphoblastic transformation of myelodysplastic syndrome |
| title_full_unstemmed | Lymphoblastic transformation of myelodysplastic syndrome |
| title_short | Lymphoblastic transformation of myelodysplastic syndrome |
| title_sort | lymphoblastic transformation of myelodysplastic syndrome |
| topic | Myelodysplastic syndrome Acute lymphoblastic leukemia Clonal evolution |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000400009&lng=en&tlng=en |
| work_keys_str_mv | AT carmensilviapassoslima lymphoblastictransformationofmyelodysplasticsyndrome AT carminoantoniodesouza lymphoblastictransformationofmyelodysplasticsyndrome AT izildaaparecidacardinalli lymphoblastictransformationofmyelodysplasticsyndrome AT irenelorandmetze lymphoblastictransformationofmyelodysplasticsyndrome |