| الملخص: | Porous polyether ether ketone (PEEK) scaffolds with hydroxyapatite (HA) layer coated on the pore wall surface were prepared using sacrificial porogen of HA-coated sodium chloride (NaCl) microspheres. The manufacture of bionic porogen was structurally inspired by the Chinese traditional food Matuan, which is a glutinous rice ball stuck with sesames. Spherical-shaped NaCl@HA microspheres with a uniform size facilitated the generation of an interconnected porous PEEK@HA scaffold with a HA coating layer on the pore surface. And the mechanical properties of PEEK@HA scaffolds were not affected by the coating layer of HA compared with PEEK porous scaffolds. After immersing in simulated body fluid and transplanting in rat proximal tibia, the PEEK@HA porous implants possessed superior in vitro biomineralization and in vivo osseointegration due to the favorable environment of the HA layer for bone ingrowth. This facile manufacturing strategy provides a unique perspective to integratedly fabricate bionic porous PEEK scaffolds with a mineralized coating layer enhancing the osseointegration of PEEK materials with bony tissue interfaces in orthopedics and stomatology. It also presents a general platform for further creating multifunctional porous PEEK implants, such as antibacterial, immunomodulatory, and photothermal therapy, by coating various inorganic nanoparticles with desired characteristics on the pore wall surface.
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