Hospitalization requiring intensive care unit due to SARS-CoV-2 infection correlated with IgM depression and IgG elevation

• 出版年: Future Science OA
• 主要な著者: Sara Tamizuddin, Jason Cham, Yasamin Ghiasi, Luis Borroto, Cindy Cao, Natalia Orendain, Michael M Quigley, Laura J Nicholson, Amitabh C Pandey
• フォーマット: 論文
• 言語: 英語
• 出版事項: Taylor & Francis Group 2022-03-01
• 主題: antibody response; COVID-19; ICU; immunology; infectious disease; SARS-CoV-2
• オンライン･アクセス: https://www.future-science.com/doi/10.2144/fsoa-2021-0126
• ISSN: 2056-5623

Aim: This study investigated the humoral response against SARS-CoV-2 in patients needing intensive care unit (ICU) care compared with those on general medicine wards. Materials & methods: The authors retrospectively reviewed 113 hospitalized patients with COVID-19. They assessed antibody response against five SARS-CoV-2 epitopes at 6–14 days post symptom onset in these patients. Results: Patients with ICU admissions had decreased anti-nucleocapsid immunoglobulin (Ig)M and increased anti-spike IgG compared with patients not requiring the ICU. IgG levels were positively correlated with length of stay. Conclusion: Higher levels of IgG against the spike protein correlate with COVID-19 disease severity and length of stay in hospitalized patients. This adds to the knowledge of biochemical response to clinical disease and may help predict ICU needs.