“Restless Nights, Stressed Hearts”: The Link Between Sleep Disorders and Takotsubo Syndrome—A Comprehensive Review

Takotsubo syndrome (TTS), also known as stress-induced cardiomyopathy or “broken heart syndrome”, is characterized by transient left ventricular dysfunction, often triggered by emotional or physical stress. Emerging evidence suggests that sleep-disordered breathing (SDB) and sleep disruption may pla...

Full description

Bibliographic Details
Published in:	Reviews in Cardiovascular Medicine
Main Authors:	Ioannis Alevroudis, Magda Petridou, Agni Sakkou, Serafeim-Chrysovalantis Kotoulas, Sotirios Matzolas, Panagiotis Roumelis, Maria Stougianni, Eleni Massa, Eleni Mouloudi
Format:	Article
Language:	English
Published:	IMR Press 2025-05-01
Subjects:	insomnia obstructive sleep apnea restless leg syndrome sleep deprivation takotsubo syndrome hypothalamic-pituitary-adrenal (hpa) axis elevated catecholamine levels heart rate variability
Online Access:	https://www.imrpress.com/journal/RCM/26/5/10.31083/RCM28244

Similar Items

Pathogenesis of Takotsubo syndrome
by: Daniele Masarone, et al.
Published: (2017-01-01)

Insulin resistance in Takotsubo syndrome
by: Bastian Bruns, et al.
Published: (2024-06-01)

Restless legs syndrome in patients on dialysis
by: Al-Jahdali Hamdan, et al.
Published: (2009-01-01)

Restless legs syndrome and impact on work performance
by: Diana Samara
Published: (2016-02-01)

Association with Asthma and Restless Legs Syndrome and Sleep Quality
by: Aygül Güneş, et al.
Published: (2019-03-01)

Depression and Sleep Quality in Restless Legs Syndrome/Willis-Ekbom Disease
by: Ceyhun Sayman, et al.
Published: (2023-06-01)

Restless Legs Syndrome in Nursing Practice
by: Łukasz Chełminiak, et al.
Published: (2018-06-01)

Is restless legs syndrome in Parkinson disease patients associated with any specific factor?
by: Manoel Alves SOBREIRA-NETO, et al.
Published: (2021-02-01)

The Effect of Foot Reflexology Massage on the Sleep Quality of Elderly Women With Restless Leg Syndrome
by: Amine Abbasi Fakhravari, et al.
Published: (2018-05-01)

Restless Legs Syndrome and Quality of Sleep in Pre-diabetic Patients: A Cross Sectional Study
by: S Razmeh, et al.
Published: (2024-04-01)

Sleep Disorders and Restless Legs Syndrome in Schoolage Pediatric Population
by: İbrahim Erdim, et al.
Published: (2022-06-01)

Prevalence of Restless Legs Syndrome and its related Factors among Older Adults in Eslamabad-e-Gharb, Iran
by: Mohammadali Morowatisharifabad, et al.
Published: (2022-12-01)

Migraine and restless legs syndrome – is there an association?
by: D. Bučaitė, et al.
Published: (2023-10-01)

Migraine and restless legs syndrome – is there an association?
by: D. Bučaitė, et al.
Published: (2023-10-01)

Exploring the Landscape of Restless Legs Syndrome: A Cross-sectional Study
by: Stella Maris Valiensi, et al.
Published: (2025-04-01)

Blood Biomarkers in Takotsubo Syndrome Point to an Emerging Role for Inflammaging in Endothelial Pathophysiology
by: Michiaki Nagai, et al.
Published: (2023-06-01)

Two pedigrees with restless legs syndrome in Brazil
by: A.M. Esteves, et al.
Published: (2008-02-01)

Association of restless leg syndrome with fatigue and sleep quality among students taking paracetamol
by: Ayesha Rehman, et al.
Published: (2024-06-01)

Restless legs syndrome in chronic obstructive pulmonary disease
by: Fariba Rezaeetalab, et al.
Published: (2017-05-01)

The Effect of Wet Cupping Therapy on Patients' Symptom Level and Sleep Quality on Restless Leg Syndrome
by: Gülsüm Yurttutan, et al.
Published: (2020-12-01)

Restless Leg Syndrome In Pregnancy: An Experience From Low Socio-Economic Population Of Karachi
by: Muhammad Ishaq, et al.
Published: (2024-11-01)

Takotsubo cardiomyopathy in a young women after cosmetic laser treatment for facial mole removal
by: Peng Po-Sen, et al.
Published: (2018-01-01)

Restless Chest Syndrome: A Rare Variant of Restless Legs Syndrome
by: Kosuke Ishizuka, et al.
Published: (2022-07-01)

Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score
by: Loïc Faucher, et al.
Published: (2025-04-01)

Acupressure reduces the severity of restless legs syndrome in hemodialysis patients: A cluster-randomized crossover pilot study
by: Li-Hung Tsai, et al.
Published: (2022-06-01)

The Relationship Between 25 (OH) Vitamin D Level and the Severity of Disease and Sleep Quality in Restless Legs Syndrome
by: Arife Çimen Atalar
Published: (2019-06-01)

CBD and THC - influence on insomnia, sleep apnea and restless leg syndrome - review based on recent advances
by: Michał Tomkiewicz, et al.
Published: (2023-02-01)

Restless leg syndrome, sleep quality and fatigue in multiple sclerosis patients
by: N.C.V. Moreira, et al.
Published: (2008-10-01)

The Relationship Between Vitamin D Deficiency and Restless Legs Syndrome in Pregnancy
by: Gonca Sağlam, et al.
Published: (2020-06-01)

Association of restless legs syndrome with malnutrition,inflammation and sleep quality in hemodialysis patients
by: HUANG Hua-xing, et al.
Published: (2017-01-01)

Restless leg syndrome exacerbated by amytriptiline in a patient with Duchenne Muscular Dystrophy
by: Ricardo Tera Akamine, et al.
Published: (2014-09-01)

The Effect of Heat Therapy on the Severity of Restless Legs Syndrome and Sleep Quality in the Elderly
by: Hojjat Azizkhani, et al.
Published: (2022-09-01)

Restless legs syndrome/Willis-Ekbom disease in multiple sclerosis: a contributing factor for anxiety, disability, sleep disorder, and quality of life
by: Meral Seferoğlu, et al.
Published: (2020-11-01)

Restless legs syndrome: abbreviated guidelines by the German sleep society and the German neurological society
by: Claudia Trenkwalder, et al.
Published: (2024-11-01)

A Case of Takotsubo Cardiomyopathy and Posterior Reversible Encephalopathy Syndrome Following Methadone Withdrawal
by: Sacide S. Ozgur, et al.
Published: (2025-03-01)

Prevalence and Awareness of Restless Leg Syndrome in Medical Students and Associated Self Reported Sleep Problems
by: Tuğba Yıldız, et al.
Published: (2024-09-01)

Editorial: The punctual night knocker: circadian rhythm of restless legs syndrome
by: Xiao-Ying Zhu, et al.
Published: (2024-01-01)

Effect of stellate ganglion block on uremic restless legs syndrome
by: ZHANG Ning*，XIE Qipeng，ZHANG Weiwei，FENG Miaomiao，WANG Yunchang，ZHOU Tianyu
Published: (2025-06-01)

Repetitive Transcranial Magnetic Stimulation for the Treatment of Restless Legs Syndrome
by: Yi-Cong Lin, et al.
Published: (2015-01-01)

A rare case report of catecholamine-induced takotsubo in a patient with anaphylaxis shock due to amoxicillin–clavulanate
by: Thang Quoc Le, et al.
Published: (2025-04-01)