Feasibility and First Results of Heart Failure Monitoring Using the Wearable Cardioverter–Defibrillator in Newly Diagnosed Heart Failure with Reduced Ejection Fraction

• 发表在: Sensors
• Main Authors: Henrike Aenne Katrin Hillmann, Stephan Hohmann, Johanna Mueller-Leisse, Christos Zormpas, Jörg Eiringhaus, Johann Bauersachs, Christian Veltmann, David Duncker
• 格式: 文件
• 语言: 英语
• 出版: MDPI AG 2021-11-01
• 主题: wearable cardioverter–defibrillator; sudden cardiac death; heart failure; heart failure monitoring
• 在线阅读: https://www.mdpi.com/1424-8220/21/23/7798

The wearable cardioverter–defibrillator (WCD) is used in patients with newly diagnosed heart failure and reduced ejection fraction (HFrEF). In addition to arrhythmic events, the WCD provides near-continuous telemetric heart failure monitoring. The purpose of this study was to evaluate the clinical relevance of additionally recorded parameters, such as heart rate or step count. We included patients with newly diagnosed HFrEF prescribed with a WCD. Via the WCD, step count and heart rate were acquired, and an approximate for heart rate variability (HRV5) was calculated. Multivariate analysis was performed to analyze predictors for an improvement in left ventricular ejection fraction (LVEF). Two hundred and seventy-six patients (31.9% female) were included. Mean LVEF was 25.3 ± 8.5%. Between the first and last seven days of usage, median heart rate fell significantly (<i>p</i> < 0.001), while median step count and HRV5 significantly increased (<i>p</i> < 0.001). In a multivariate analysis, a delta of HRV5 > 23 ms was an independent predictor for LVEF improvement of ≥10% between prescription and 3-month follow-up. Patients with newly diagnosed HFrEF showed significant changes in heart rate, step count, and HRV5 between the beginning and end of WCD prescription time. HRV5 was an independent predictor for LVEF improvement and could serve as an early indicator of treatment response.