The nuts and bolts of the platelet release reaction

Secretion is essential to many of the roles that platelets play in the vasculature, e.g., thrombosis, angiogenesis, and inflammation, enabling platelets to modulate the microenvironment at sites of vascular lesions with a myriad of bioactive molecules stored in their granules. Past studies demonstra...

Full description

Bibliographic Details
Published in:	Platelets
Main Authors:	Smita Joshi, Sidney W. Whiteheart
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2017-02-01
Subjects:	exocytosis munc13 munc18 rab snares stxbp5
Online Access:	http://dx.doi.org/10.1080/09537104.2016.1240768

Similar Items

Neuronal SNARE complex assembly guided by Munc18‐1 and Munc13‐1
by: Shen Wang, et al.
Published: (2022-11-01)

Exploring the Two Coupled Conformational Changes That Activate the Munc18-1/Syntaxin-1 Complex
by: Jihong Gong, et al.
Published: (2021-12-01)

Identification of residues critical for the extension of Munc18-1 domain 3a
by: Xianping Wang, et al.
Published: (2023-07-01)

Multiple factors maintain assembled trans-SNARE complexes in the presence of NSF and αSNAP
by: Eric A Prinslow, et al.
Published: (2019-01-01)

Autoinhibition of Munc18-1 modulates synaptobrevin binding and helps to enable Munc13-dependent regulation of membrane fusion
by: Ewa Sitarska, et al.
Published: (2017-05-01)

Targeted stabilization of Munc18‐1 function via pharmacological chaperones
by: Debra Abramov, et al.
Published: (2020-12-01)

Munc18-1-regulated stage-wise SNARE assembly underlying synaptic exocytosis
by: Lu Ma, et al.
Published: (2015-12-01)

Functional synergy between the Munc13 C-terminal C1 and C2 domains
by: Xiaoxia Liu, et al.
Published: (2016-05-01)

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis
by: Alexander M Walter, et al.
Published: (2017-10-01)

Sec17 (α-SNAP) and an SM-tethering complex regulate the outcome of SNARE zippering in vitro and in vivo
by: Matthew L Schwartz, et al.
Published: (2017-09-01)

Extracellular Alpha-Synuclein Promotes a Neuroinhibitory Secretory Phenotype in Astrocytes
by: Bruno Di Marco Vieira, et al.
Published: (2020-09-01)

CAPS and Munc13: CATCHRs that SNARE vesicles
by: Declan J James, et al.
Published: (2013-12-01)

Mechanisms that regulate the C1-C2B mutual inhibition control functional switch of UNC-13
by: Haowen Liu, et al.
Published: (2025-04-01)

Protein expression of PKCZ (Protein Kinase C Zeta), Munc18c, and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic ovary syndrome (PCOS)
by: Rivero Rodrigo, et al.
Published: (2012-03-01)

Effects of Munc13-1 and Munc18-1 on dopamine secretion dysfunction in manganese-exposed SH-SY5Y cells
by: Changzhe LI, et al.
Published: (2023-03-01)

Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region
by: Marcial Camacho, et al.
Published: (2021-11-01)

UNC13D mutation presenting as fulminant familial hemophagocytic lymphohistiocytosis
by: Chun-Hua Liao, et al.
Published: (2020-12-01)

Similarity and Diversity of Presynaptic Molecules at Neuromuscular Junctions and Central Synapses
by: Kenji Takikawa, et al.
Published: (2022-01-01)

Cocaine Self-Administration and Abstinence Modulate NMDA Receptor Subunits and Active Zone Proteins in the Rat Nucleus Accumbens
by: Irena Smaga, et al.
Published: (2020-07-01)

Munc13-1 translocates to the plasma membrane in a Doc2B- and calcium-dependent manner
by: Reut eFriedrich, et al.
Published: (2013-09-01)

Regulation of Syntaxin3B-Mediated Membrane Fusion by T14, Munc18, and Complexin
by: Rajkishor Nishad, et al.
Published: (2023-09-01)

Membrane bridging by Munc13-1 is crucial for neurotransmitter release
by: Bradley Quade, et al.
Published: (2019-02-01)

Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics
by: Keming Zhou, et al.
Published: (2013-11-01)

CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles
by: Brian D Mueller, et al.
Published: (2023-02-01)

The complementary roles of VAMP-2, -3, and -7 in platelet secretion and function
by: Smita Joshi, et al.
Published: (2023-12-01)

Molecular Docking and Dynamics Simulation Studies Predict Munc18b as a Target of Mycolactone: A Plausible Mechanism for Granule Exocytosis Impairment in Buruli Ulcer Pathogenesis
by: Samuel K. Kwofie, et al.
Published: (2019-03-01)

Delineating the Molecular Basis of the Calmodulin–bMunc13-2 Interaction by Cross-Linking/Mass Spectrometry—Evidence for a Novel CaM Binding Motif in bMunc13-2
by: Christine Piotrowski, et al.
Published: (2020-01-01)

Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones
by: Chao Tan, et al.
Published: (2022-11-01)

Translating neuronal activity at the synapse: presynaptic calcium sensors in short-term plasticity
by: Arthur P.H. De Jong, et al.
Published: (2014-10-01)

A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release
by: Marisa M. Brockmann, et al.
Published: (2020-08-01)

Griscelli Syndrome Type 2 Sine Albinism: Unraveling Differential RAB27A Effector Engagement
by: Yuta Ohishi, et al.
Published: (2020-12-01)

Loss of synaptic Munc13-1 underlies neurotransmission abnormalities in spinal muscular atrophy
by: Mehri Moradi, et al.
Published: (2025-08-01)

Phosphorylation of the N-terminus of Syntaxin-16 controls interaction with mVps45 and GLUT4 trafficking in adipocytes
by: Shaun K. Bremner, et al.
Published: (2023-07-01)

Skewed distribution of spines is independent of presynaptic transmitter release and synaptic plasticity, and emerges early during adult neurogenesis
by: Nina Rößler, et al.
Published: (2023-08-01)

Comparison of Two Fiber Post Removal Techniques Evaluating Dentin Removal, Efficiency, and Heat Production
by: Matthew Fenigstein, et al.
Published: (2025-05-01)

The accessory helix of complexin functions by stabilizing central helix secondary structure
by: Daniel T Radoff, et al.
Published: (2014-11-01)

The SNARE machinery in mast cell secretion
by: Axel eLorentz, et al.
Published: (2012-06-01)

Rab3a attenuates spinal cord injury by mediating vesicle release
by: Yuhao Yang, et al.
Published: (2024-03-01)

α-Synuclein is the major platelet isoform but is dispensable for activation, secretion, and thrombosis
by: Alexis N. Smith, et al.
Published: (2023-12-01)

Heterologous Expression of Arabidopsis AtARA6 in Soybean Enhances Salt Tolerance
by: Zhipeng Hong, et al.
Published: (2022-05-01)