Identification of DEAD-Box RNA Helicase DDX41 as a Trafficking Protein That Involves in Multiple Innate Immune Signaling Pathways in a Zebrafish Model
DDX41 is an important sensor for host recognition of DNA viruses and initiation of nuclear factor-κB (NF-κB) and IFN signaling pathways in mammals. However, its occurrence and functions in other vertebrates remain poorly defined. Here, a DDX41 ortholog [Danio rerio DDX41 (DrDDX41)] with various cons...
| 發表在: | Frontiers in Immunology |
|---|---|
| Main Authors: | Jun-xia Ma, Jiang-yuan Li, Dong-dong Fan, Wei Feng, Ai-fu Lin, Li-xin Xiang, Jian-zhong Shao |
| 格式: | Article |
| 語言: | 英语 |
| 出版: |
Frontiers Media S.A.
2018-06-01
|
| 主題: | |
| 在線閱讀: | https://www.frontiersin.org/article/10.3389/fimmu.2018.01327/full |
相似書籍
Unique role of DDX41, a DEAD-box type RNA helicase, in hematopoiesis and leukemogenesis
由: Satoru Shinriki, et al.
出版: (2022-09-01)
由: Satoru Shinriki, et al.
出版: (2022-09-01)
Combination therapy with venetoclax and azacitidine for the treatment of myelodysplastic syndromes with DDX41 mutations
由: Xin Wang, et al.
出版: (2024-12-01)
由: Xin Wang, et al.
出版: (2024-12-01)
The BTK-DDX41 axis of the STING pathway is activated during cytomegalovirus lytic infection
由: Vargab Baruah, et al.
出版: (2025-10-01)
由: Vargab Baruah, et al.
出版: (2025-10-01)
Helicase protein DDX11 as a novel antiviral factor promoting RIG-I-MAVS-mediated signaling pathway
由: Jiyu Zhang, et al.
出版: (2024-12-01)
由: Jiyu Zhang, et al.
出版: (2024-12-01)
Clinical Outcome and Molecular Profile in Patients with <i>DDX41</i> Mutation Hot-Spots
由: Nadia Toumeh, et al.
出版: (2025-05-01)
由: Nadia Toumeh, et al.
出版: (2025-05-01)
The human DEAD-box helicase DDX3X as a regulator of mRNA translation
由: Cathal S. Ryan, et al.
出版: (2022-10-01)
由: Cathal S. Ryan, et al.
出版: (2022-10-01)
The Interaction of Mandarin Fish DDX41 with STING Evokes type I Interferon Responses Inhibiting Ranavirus Replication
由: Xiao-Wei Qin, et al.
出版: (2022-12-01)
由: Xiao-Wei Qin, et al.
出版: (2022-12-01)
The DEAD-box RNA helicase, DDX60, Suppresses immunotherapy and promotes malignant progression of pancreatic cancer
由: Tiantian Lai, et al.
出版: (2023-07-01)
由: Tiantian Lai, et al.
出版: (2023-07-01)
The emerging roles of the DDX41 protein in immunity and diseases
由: Yan Jiang, et al.
出版: (2016-08-01)
由: Yan Jiang, et al.
出版: (2016-08-01)
Pan-cancer analysis of the prognostic and immunological roles of DEAD-box helicase 5 (DDX5) in human tumors
由: Shixuan Liu, et al.
出版: (2022-10-01)
由: Shixuan Liu, et al.
出版: (2022-10-01)
DEAD-Box RNA Helicases in Cell Cycle Control and Clinical Therapy
由: Lu Zhang, et al.
出版: (2021-06-01)
由: Lu Zhang, et al.
出版: (2021-06-01)
Biallelic disruption of DDX41 activity is associated with distinct genomic and immunophenotypic hallmarks in acute leukemia
由: Anne Tierens, et al.
出版: (2023-06-01)
由: Anne Tierens, et al.
出版: (2023-06-01)
Case Report of a DDX41 Germline Mutation in a Family with Multiple Relatives Suffering from Leukemia
由: Jan Nicolai Wagner, et al.
出版: (2023-12-01)
由: Jan Nicolai Wagner, et al.
出版: (2023-12-01)
Next‐generation sequencing reveals the presence of DDX41 mutations in acute lymphoblastic leukemia and aplastic anemia
由: Yang Zhang, et al.
出版: (2021-08-01)
由: Yang Zhang, et al.
出版: (2021-08-01)
DEAD box RNA helicase 5 is a new pro-viral host factor for Sindbis virus infection
由: Mélanie Messmer, et al.
出版: (2024-03-01)
由: Mélanie Messmer, et al.
出版: (2024-03-01)
DEAD-box RNA helicase 21 negatively regulates cytosolic RNA-mediated innate immune signaling
由: Jia Li, et al.
出版: (2022-08-01)
由: Jia Li, et al.
出版: (2022-08-01)
RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X
由: Sundy N. Y. Yang, et al.
出版: (2020-01-01)
由: Sundy N. Y. Yang, et al.
出版: (2020-01-01)
RNA Helicase DDX3 Interacts with the Capsid Protein of Hepatitis E Virus and Plays a Vital Role in the Viral Replication
由: Shaoli Lin, et al.
出版: (2025-02-01)
由: Shaoli Lin, et al.
出版: (2025-02-01)
Corrigendum: DEAD-Box Helicase DDX6 Facilitated RIG-I-Mediated Type-I Interferon Response to EV71 Infection
由: Rui Zhang, et al.
出版: (2021-10-01)
由: Rui Zhang, et al.
出版: (2021-10-01)
A Dual Role of DDX3X in dsRNA-Derived Innate Immune Signaling
由: Juntae Kwon, et al.
出版: (2022-07-01)
由: Juntae Kwon, et al.
出版: (2022-07-01)
DEAD-Box Helicase DDX25 Is a Negative Regulator of Type I Interferon Pathway and Facilitates RNA Virus Infection
由: Tingting Feng, et al.
出版: (2017-08-01)
由: Tingting Feng, et al.
出版: (2017-08-01)
Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity
由: Steven M. Heaton, et al.
出版: (2019-09-01)
由: Steven M. Heaton, et al.
出版: (2019-09-01)
Comparative Transcriptomics Analyses Identify DDX43 as a Cellular Regulator Involved in Suppressing HSV-2 Replication
由: Ranqing Cheng, et al.
出版: (2025-10-01)
由: Ranqing Cheng, et al.
出版: (2025-10-01)
The Role of the RNA Helicase DDX3X in Medulloblastoma Progression
由: Akanksha Swarup, et al.
出版: (2024-07-01)
由: Akanksha Swarup, et al.
出版: (2024-07-01)
Identification of a novel nuclease activity in human DDX49 helicase
由: Ashley J. Parkes, et al.
出版: (2024-12-01)
由: Ashley J. Parkes, et al.
出版: (2024-12-01)
An in‐cell helicase reporter system for quantifying DDX3X and DDX3Y activities
由: Zhi Sheng Poh, et al.
出版: (2025-05-01)
由: Zhi Sheng Poh, et al.
出版: (2025-05-01)
RNA helicase DEAD-box-5 is involved in R-loop dynamics of preimplantation embryos
由: Hyeonji Lee, et al.
出版: (2024-06-01)
由: Hyeonji Lee, et al.
出版: (2024-06-01)
DDX58 deficiency leads to triple negative breast cancer chemotherapy resistance by inhibiting Type I IFN-mediated signalling apoptosis
由: Shiyu Cao, et al.
出版: (2024-03-01)
由: Shiyu Cao, et al.
出版: (2024-03-01)
DEAD-Box Helicase 17 Promotes Amyloidogenesis by Regulating BACE1 Translation
由: Yue Liu, et al.
出版: (2023-04-01)
由: Yue Liu, et al.
出版: (2023-04-01)
CRL2LRRC41-Mediated DDX5 Ubiquitination Enhances Interaction with ELAVL1 Preventing NOG mRNA Degradation and Sustaining Proliferation and Migration of Human Spermatogonial Stem Cell-Like Cell Line
由: Bing Jiang, et al.
出版: (2025-08-01)
由: Bing Jiang, et al.
出版: (2025-08-01)
Deletion of <i>ddx4</i> Ovary-Specific Transcript Causes Dysfunction of Meiosis and Derepress of DNA Transposons in Zebrafish Ovaries
由: Yuanyuan Chen, et al.
出版: (2024-12-01)
由: Yuanyuan Chen, et al.
出版: (2024-12-01)
Expression of DDX5 and DDX17 in ovarian cancer tissues and their effects on proliferation and drug resistance of human ovarian cancer cell line SKOV3
由: HUANG Jie, LI Runbo, GUO Jianxin, HAN Jian
出版: (2023-08-01)
由: HUANG Jie, LI Runbo, GUO Jianxin, HAN Jian
出版: (2023-08-01)
Pan-cancer analysis and breast cancer validation reveal DEAD-box helicase 23 as a crucial prognostic and immuno-biomarker
由: Haotian Ma, et al.
出版: (2026-04-01)
由: Haotian Ma, et al.
出版: (2026-04-01)
Regulation of the U3-, U8-, and U13snoRNA Expression by the DEAD Box Proteins Ddx5/Ddx17 with Consequences for Cell Proliferation and Survival
由: Hala Ismael, et al.
出版: (2016-09-01)
由: Hala Ismael, et al.
出版: (2016-09-01)
DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression
由: Kun Xu, et al.
出版: (2022-08-01)
由: Kun Xu, et al.
出版: (2022-08-01)
Corrigendum: DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression
由: Kun Xu, et al.
出版: (2023-06-01)
由: Kun Xu, et al.
出版: (2023-06-01)
DEAD-Box Helicase 27 Triggers Epithelial to Mesenchymal Transition by Regulating Alternative Splicing of Lipoma-Preferred Partner in Gastric Cancer Metastasis
由: Yirong Jin, et al.
出版: (2022-05-01)
由: Yirong Jin, et al.
出版: (2022-05-01)
DEAD‐Box Helicase 6 Blockade in Brain‐Derived Aβ Oligomers From Alzheimer's Disease Patients Attenuates Neurotoxicity
由: Xiaoxu Wang, et al.
出版: (2025-05-01)
由: Xiaoxu Wang, et al.
出版: (2025-05-01)
DEAD-Box RNA Helicase 21 (DDX21) Positively Regulates the Replication of Porcine Reproductive and Respiratory Syndrome Virus via Multiple Mechanisms
由: Jia Li, et al.
出版: (2022-02-01)
由: Jia Li, et al.
出版: (2022-02-01)
RNA helicase DDX21 sustains hematopoietic stem cell homeostasis by preventing nucleolar stress
由: Yalan Xiao, et al.
出版: (2026-03-01)
由: Yalan Xiao, et al.
出版: (2026-03-01)
相似書籍
-
Unique role of DDX41, a DEAD-box type RNA helicase, in hematopoiesis and leukemogenesis
由: Satoru Shinriki, et al.
出版: (2022-09-01) -
Combination therapy with venetoclax and azacitidine for the treatment of myelodysplastic syndromes with DDX41 mutations
由: Xin Wang, et al.
出版: (2024-12-01) -
The BTK-DDX41 axis of the STING pathway is activated during cytomegalovirus lytic infection
由: Vargab Baruah, et al.
出版: (2025-10-01) -
Helicase protein DDX11 as a novel antiviral factor promoting RIG-I-MAVS-mediated signaling pathway
由: Jiyu Zhang, et al.
出版: (2024-12-01) -
Clinical Outcome and Molecular Profile in Patients with <i>DDX41</i> Mutation Hot-Spots
由: Nadia Toumeh, et al.
出版: (2025-05-01)
