Replication-independent endogenous DNA double-strand breaks in Saccharomyces cerevisiae model.

Without exposure to any DNA-damaging agents, non-dividing eukaryotic cells carry endogenous DNA double-strand breaks (EDSBs), or Replication-Independent (RIND)-EDSBs. In human cells, RIND-EDSBs are enriched in the methylated heterochromatic areas of the genome and are repaired by an ATM-dependent no...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Jirapan Thongsroy, Oranart Matangkasombut, Araya Thongnak, Prakasit Rattanatanyong, Siwanon Jirawatnotai, Apiwat Mutirangura
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Online Access:	http://europepmc.org/articles/PMC3747138?pdf=render