Goji Berry Fruit Extract Suppresses Cell Proliferation of Breast Cancer Cells by Inhibiting EGFR/ERK Signalling
Herbal medicines have been used in cancer treatment, with many exhibiting favorable side effect and toxicity profiles compared with conventional chemotherapeutic agents. The aim of this study was to verify whether Lycium barbarum fruit (red and black fruit) extracts inhibit proliferation of MDA-MB-2...
| Published in: | Proceedings |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2017-11-01
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| Online Access: | https://www.mdpi.com/2504-3900/1/10/1058 |
| _version_ | 1850030651455045632 |
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| author | Hatice Bekci Guzide Satır Basaran Ayse Baldemir Ahmet Cumaoglu |
| author_facet | Hatice Bekci Guzide Satır Basaran Ayse Baldemir Ahmet Cumaoglu |
| author_sort | Hatice Bekci |
| collection | DOAJ |
| container_title | Proceedings |
| description | Herbal medicines have been used in cancer treatment, with many exhibiting favorable side effect and toxicity profiles compared with conventional chemotherapeutic agents. The aim of this study was to verify whether Lycium barbarum fruit (red and black fruit) extracts inhibit proliferation of MDA-MB-231cells through EGFR/ERK pathway. Cytotoxicity with MTT reduction assay and phosphorylation of EGFR and ERK were analyzed by western blot. IC50 values were 87.0 and 79.4 µg/mL for goji berry black fruit extract (GBBFE) and goji berry red fruit extract (GBRFE) expectively. Pretreatment with both extract inhibited phosphorylation of EGFR/ERK in EGF-treated cells. Goji berry fruit extracts cause cellular death of MDA-MB-231 breast cancer cells by inhibiting EGFR/ERK signaling and this study suggests that Goji berry fruit extracts could be beneficial for treating breast cancer. |
| format | Article |
| id | doaj-art-e18da92b95e34f6aa97c4f68e1856ed4 |
| institution | Directory of Open Access Journals |
| issn | 2504-3900 |
| language | English |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-e18da92b95e34f6aa97c4f68e1856ed42025-08-20T00:36:09ZengMDPI AGProceedings2504-39002017-11-01110105810.3390/proceedings1101058proceedings1101058Goji Berry Fruit Extract Suppresses Cell Proliferation of Breast Cancer Cells by Inhibiting EGFR/ERK SignallingHatice Bekci0Guzide Satır Basaran1Ayse Baldemir2Ahmet Cumaoglu3Department of Food Engineering, Engineering Faculty, Erciyes University, Kayseri 38030, TurkeyDepartment of Biochemistry, Faculty of Pharmacy, Erciyes University, Kayseri 38030, TurkeyDepartment of Pharmaceutical botany, Faculty of Pharmacy, Erciyes University, Kayseri 38030, TurkeyDepartment of Biochemistry, Faculty of Pharmacy, Erciyes University, Kayseri 38030, TurkeyHerbal medicines have been used in cancer treatment, with many exhibiting favorable side effect and toxicity profiles compared with conventional chemotherapeutic agents. The aim of this study was to verify whether Lycium barbarum fruit (red and black fruit) extracts inhibit proliferation of MDA-MB-231cells through EGFR/ERK pathway. Cytotoxicity with MTT reduction assay and phosphorylation of EGFR and ERK were analyzed by western blot. IC50 values were 87.0 and 79.4 µg/mL for goji berry black fruit extract (GBBFE) and goji berry red fruit extract (GBRFE) expectively. Pretreatment with both extract inhibited phosphorylation of EGFR/ERK in EGF-treated cells. Goji berry fruit extracts cause cellular death of MDA-MB-231 breast cancer cells by inhibiting EGFR/ERK signaling and this study suggests that Goji berry fruit extracts could be beneficial for treating breast cancer.https://www.mdpi.com/2504-3900/1/10/1058Goji berrycancerEGFR/ERK |
| spellingShingle | Hatice Bekci Guzide Satır Basaran Ayse Baldemir Ahmet Cumaoglu Goji Berry Fruit Extract Suppresses Cell Proliferation of Breast Cancer Cells by Inhibiting EGFR/ERK Signalling Goji berry cancer EGFR/ERK |
| title | Goji Berry Fruit Extract Suppresses Cell Proliferation of Breast Cancer Cells by Inhibiting EGFR/ERK Signalling |
| title_full | Goji Berry Fruit Extract Suppresses Cell Proliferation of Breast Cancer Cells by Inhibiting EGFR/ERK Signalling |
| title_fullStr | Goji Berry Fruit Extract Suppresses Cell Proliferation of Breast Cancer Cells by Inhibiting EGFR/ERK Signalling |
| title_full_unstemmed | Goji Berry Fruit Extract Suppresses Cell Proliferation of Breast Cancer Cells by Inhibiting EGFR/ERK Signalling |
| title_short | Goji Berry Fruit Extract Suppresses Cell Proliferation of Breast Cancer Cells by Inhibiting EGFR/ERK Signalling |
| title_sort | goji berry fruit extract suppresses cell proliferation of breast cancer cells by inhibiting egfr erk signalling |
| topic | Goji berry cancer EGFR/ERK |
| url | https://www.mdpi.com/2504-3900/1/10/1058 |
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