Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF
On culture of hippocampal HT-22 cells line it is shown that dimeric dipeptide mimetiks of different Loops of NGF realize their action via specific neurotrophic TrkA-receptor and selective activate post-receptor intracellular signal ways. Mimetiks of 1th (GK-6 (10-6M)) and the 3rd Loops (GTS-115 ((10...
| 發表在: | Фармакокинетика и Фармакодинамика |
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| Main Authors: | , , , , , , , |
| 格式: | Article |
| 語言: | 俄语 |
| 出版: |
LLC “Publisher OKI”
2016-03-01
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| 主題: | |
| 在線閱讀: | https://www.pharmacokinetica.ru/jour/article/view/168 |
| _version_ | 1849465584393125888 |
|---|---|
| author | T. A. Antipova I. O. Logvinov S. V. Nikolaev S. V. Kruglov A. V. Tarasiuk P. I. Antipov T. A. Gudasheva S. B. Seredenin |
| author_facet | T. A. Antipova I. O. Logvinov S. V. Nikolaev S. V. Kruglov A. V. Tarasiuk P. I. Antipov T. A. Gudasheva S. B. Seredenin |
| author_sort | T. A. Antipova |
| collection | DOAJ |
| container_title | Фармакокинетика и Фармакодинамика |
| description | On culture of hippocampal HT-22 cells line it is shown that dimeric dipeptide mimetiks of different Loops of NGF realize their action via specific neurotrophic TrkA-receptor and selective activate post-receptor intracellular signal ways. Mimetiks of 1th (GK-6 (10-6M)) and the 3rd Loops (GTS-115 ((10-6M)) evoke activation of two main signal cascades - PI3/Akt and MAP/Erk, while mimetic the 4th loop of NGF (GK-2 (10-8M)) only one - a PI3/Akt-way. |
| format | Article |
| id | doaj-art-e196399e3ccb4e7e86fdadb54fb902b5 |
| institution | Directory of Open Access Journals |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2016-03-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| spelling | doaj-art-e196399e3ccb4e7e86fdadb54fb902b52025-08-20T03:20:16ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302016-03-01021417167Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGFT. A. Antipova0I. O. Logvinov1S. V. Nikolaev2S. V. Kruglov3A. V. Tarasiuk4P. I. Antipov5T. A. Gudasheva6S. B. Seredenin7FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»FSBI «Zakusov Institute of PharmacoLogy»On culture of hippocampal HT-22 cells line it is shown that dimeric dipeptide mimetiks of different Loops of NGF realize their action via specific neurotrophic TrkA-receptor and selective activate post-receptor intracellular signal ways. Mimetiks of 1th (GK-6 (10-6M)) and the 3rd Loops (GTS-115 ((10-6M)) evoke activation of two main signal cascades - PI3/Akt and MAP/Erk, while mimetic the 4th loop of NGF (GK-2 (10-8M)) only one - a PI3/Akt-way.https://www.pharmacokinetica.ru/jour/article/view/168ngftrk-aвнутриклеточный сигналингдимерные дипептидные миметикиngftrk-aintracellular signalingdimeric dipeptide mimetiks |
| spellingShingle | T. A. Antipova I. O. Logvinov S. V. Nikolaev S. V. Kruglov A. V. Tarasiuk P. I. Antipov T. A. Gudasheva S. B. Seredenin Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF ngf trk-a внутриклеточный сигналинг димерные дипептидные миметики ngf trk-a intracellular signaling dimeric dipeptide mimetiks |
| title | Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF |
| title_full | Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF |
| title_fullStr | Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF |
| title_full_unstemmed | Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF |
| title_short | Comparative analysis activation of post-receptor signal ways by dimeric dipeptide mimetiks of different loops of NGF |
| title_sort | comparative analysis activation of post receptor signal ways by dimeric dipeptide mimetiks of different loops of ngf |
| topic | ngf trk-a внутриклеточный сигналинг димерные дипептидные миметики ngf trk-a intracellular signaling dimeric dipeptide mimetiks |
| url | https://www.pharmacokinetica.ru/jour/article/view/168 |
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