In Situ-Forming Gels Loaded with Stimuli-Responsive Gated Mesoporous Silica Nanoparticles for Local Sustained Drug Delivery

A novel combination of in situ-forming hydrogels of hyaluronic acid with gated mesoporous materials was developed to design depots for local sustained release of chemotherapeutics. The depot consists of a hyaluronic-based gel loaded with redox-responsive mesoporous silica nanoparticles loaded with s...

Full description

Bibliographic Details
Published in:	Pharmaceutics
Main Authors:	Cristina de la Torre, Carmen Coll, Amelia Ultimo, Félix Sancenón, Ramón Martínez-Máñez, Eduardo Ruiz-Hernández
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Subjects:	mesoporous silica drug delivery molecular gates in situ-forming gels
Online Access:	https://www.mdpi.com/1999-4923/15/4/1071

Similar Items

Fluorogenic Detection of Human Serum Albumin Using Curcumin-Capped Mesoporous Silica Nanoparticles
by: Ismael Otri, et al.
Published: (2022-02-01)

Molecule gated mesoporous silica for on-command drug delivery: A review
by: Muhson Isroni, et al.
Published: (2023-12-01)

Surfactant-Triggered Molecular Gate Tested on Different Mesoporous Silica Supports for Gastrointestinal Controlled Delivery
by: Elisa Poyatos-Racionero, et al.
Published: (2020-06-01)

Mesoporous Silica Materials as an Emerging Tool for Cancer Immunotherapy
by: Blanca Escriche‐Navarro, et al.
Published: (2022-09-01)

Performance and Long Term Stability of Mesoporous Silica Membranes for Desalination
by: João C. Diniz da Costa, et al.
Published: (2013-07-01)

Anchoring Gated Mesoporous Silica Particles to Ethylene Vinyl Alcohol Films for Smart Packaging Applications
by: Virginia Muriel-Galet, et al.
Published: (2018-10-01)

Recent advances in mesoporous silica nanoparticle: synthesis, drug loading, release mechanisms, and diverse applications
by: Rabia Fatima, et al.
Published: (2025-03-01)

Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy
by: Thashini Moodley, et al.
Published: (2021-01-01)

Amine-Impregnated Dendritic Mesoporous Silica for the Adsorption of Formaldehyde
by: Ji Myeong Lee, et al.
Published: (2023-12-01)

Synthesis of Mesoporous Silica Using the Sol–Gel Approach: Adjusting Architecture and Composition for Novel Applications
by: Yandong Han, et al.
Published: (2024-05-01)

Formulation and optimization of mesoporous silica loaded gel containing extract of Rosmarinus officinalis for treatment of acute wound healing
by: Raosaheb S. Shendge, et al.
Published: (2024-08-01)

Mesoporous Silica Nanoparticles in Chemical Detection: From Small Species to Large Bio-Molecules
by: Margarita Parra, et al.
Published: (2021-12-01)

Mesoporous silica matrices derived from sol-gel process assisted by low power ultrasonic activation
by: Václav Štengl, et al.
Published: (2009-06-01)

Investigating the Trimethylaluminium/Water ALD Process on Mesoporous Silica by In Situ Gravimetric Monitoring
by: Verena E. Strempel, et al.
Published: (2018-05-01)

Facile fabrication of mesostructured natural rubber/silica nanocomposites with enhanced thermal stability and hydrophobicity
by: Supphathee Chaowamalee, et al.
Published: (2019-12-01)

Immobilization of Levocetirizine on Mesoporous Silica for Antiallergenic Gel Formulation
by: Klára Szentmihályi, et al.
Published: (2024-10-01)

Oil absorption in mesoporous silica particles
by: Radislav Filipović, et al.
Published: (2010-12-01)

Core/shell magnetic mesoporous silica nanoparticles with radially oriented wide mesopores
by: Nikola Ž. Knežević
Published: (2014-06-01)

pH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of <i>Giardia intestinalis</i>
by: Isabel González-Alvarez, et al.
Published: (2021-01-01)

Intravitreal safety profiles of sol-gel mesoporous silica microparticles and the degradation product (Si(OH)4)
by: Yaoyao Sun, et al.
Published: (2020-01-01)

Visible Light Photocleavable Ruthenium-Based Molecular Gates to Reversibly Control Release from Mesoporous Silica Nanoparticles
by: Yolanda Salinas, et al.
Published: (2020-05-01)

Tannin as a porogenic agent in the synthesis of silica by an acid-catalyzed sol-gel process
by: Fernanda A. Arzani, et al.
Published: (2025-08-01)

An Assessment of Mesoporous Silica Nanoparticle Architectures as Antigen Carriers
by: Xinyue Huang, et al.
Published: (2020-03-01)

Immobilization of Metronidazole on Mesoporous Silica Materials
by: Klára Szentmihályi, et al.
Published: (2022-10-01)

Design and fabrication of a mesoporous silica scaffold for oral delivery of peptides
by: Yasir Mehmood, et al.
Published: (2025-08-01)

Chiral Mesoporous Silica Materials: A Review on Synthetic Strategies and Applications
by: Mingshu Cui, et al.
Published: (2020-08-01)

Design of Nickel-Containing Nanocomposites Based on Ordered Mesoporous Silica: Synthesis, Structure, and Methylene Blue Adsorption
by: Tatyana Kouznetsova, et al.
Published: (2024-02-01)

Growth and Functionalization of Particle-Based Mesoporous Silica Films and Their Usage in Catalysis
by: Pei-Hsuan Wu, et al.
Published: (2019-04-01)

Propylsulfonic Acid-Functionalized Mesostructured Natural Rubber/Silica Nanocomposites as Promising Hydrophobic Solid Catalysts for Alkyl Levulinate Synthesis
by: Supphathee Chaowamalee, et al.
Published: (2022-02-01)

Study of the physicochemical characteristics of mesoporous carbons obtained by using SBA-16 mesoporous silica as template
by: Leidy Hoyos, et al.
Published: (2010-01-01)

Mesoporous Silica Nanoparticles as Theranostic Antitumoral Nanomedicines
by: Alejandro Baeza, et al.
Published: (2020-10-01)

In situ supported rhodium catalyst on mesoporous silica for chemoselective hydrogenation of nitriles to primary amines
by: Ajjou Abdelaziz Nait, et al.
Published: (2025-02-01)

Characterization and Comparison of Mesoporous Silica Particles for Optimized Drug Delivery
by: Xinyue Huang, et al.
Published: (2014-01-01)

Mesoporous Silica-Based Catalysts for Biodiesel Production: A Review
by: Is Fatimah, et al.
Published: (2023-06-01)

Degradation of Mesoporous Silica Materials in Biological Milieu: The Gateway for Therapeutic Applications
by: Sergio E. Moya, et al.
Published: (2024-10-01)

New Oleic Acid‐Capped Mesoporous Silica Particles as Surfactant‐Responsive Delivery Systems
by: Elisa Poyatos‐Racionero, et al.
Published: (2019-08-01)

Influence of Mesoporous Silica Functionalization and Pore Size on Resveratrol Release Profiles
by: Daniel Lincu, et al.
Published: (2019-10-01)

Progress in Mesoporous Silica Nanoparticles as Drug Delivery Agents for Cancer Treatment
by: Eleen Dayana Mohamed Isa, et al.
Published: (2021-01-01)

Pyranine Immobilized on Aminopropyl-Modified Mesoporous Silica Film for Paraquat Detection
by: Sudarat Sombatsri, et al.
Published: (2023-04-01)

Synthesis of Mesoporous Silica and Modified as a Drug Delivery System of Ibuprofen
by: Y. Mortazavi, et al.
Published: (2016-01-01)