A randomized controlled clinical trial to investigate the efficacy and safety of dexmedetomidine in treating postoperative acute pain

Background: This study aims to investigate the efficacy and safety of dexmedetomidine in treating postoperative acute pain through a clinical randomized controlled trial. Methods: This study selected 165 patients who underwent general anesthesia surgeries at our hospital from October 2022 to May 202...

Full description

Bibliographic Details
Published in:	Saudi Journal of Anaesthesia
Main Authors:	Yahui Liu, Jie Du, Yang Li, Qingxuan Zhang, Pu Li, Sha Li, Xiao Ma, Fupeng Xu
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2025-07-01
Subjects:	dexmedetomidine efficacy and safety postoperative acute pain randomized controlled clinical trial total abdominal hysterectomy
Online Access:	https://journals.lww.com/10.4103/sja.sja_511_24

Similar Items

Efficacy of epidural clonidine versus dexmedetomidine in postoperative analgesia with bupivacaine in total abdominal hysterectomy
by: C. Nandhini, et al.
Published: (2025-10-01)

Preoperative Anxiety and Postoperative Pain in Patients With Laparoscopic Hysterectomy
by: Lin Zhang, et al.
Published: (2021-10-01)

Gabapentin for Acute Postoperative Pain Control in Total Abdominal Hysterectomy: A randomized controlled trial
by: Hathaipat Sukjariangporn, et al.
Published: (2021-01-01)

Retraction: Effect of Two Different Doses of Dexmedetomidine as Adjuvant in Bupivacaine Induced Subarachnoid Block for Elective Abdominal Hysterectomy Operations: A Prospective, Double-blind, Randomized Controlled Study
by: Anjan Das, et al.
Published: (2020-07-01)

Comparative Study of Bupivacaine- Dexmeditomidine and Bupivacaine-Fentanyl with Bupivacaine Plain as Local Infiltration for Postoperative Analgesia After Abdominal Hysterectomy Under Subarachnoid Block
by: Brejesh Ravi Varma, et al.
Published: (2025-04-01)

The Effects of Dexmedetomidine As an Adjuvant with Levobupivacaine To Epidural Analgesia on The Outcomes of Patients Undergoing Total Abdominal Hysterectomy Surgery
by: Purwoko Purwoko, et al.
Published: (2024-03-01)

A randomized controlled trial to compare pregabalin with gabapentin for postoperative pain in abdominal hysterectomy
by: Anju Ghai, et al.
Published: (2011-01-01)

Does dexmedetomidine reduce postoperative pain after laparoscopic cholecystectomy with multimodal analgesia?
by: Jung-Kyu Park, et al.
Published: (2012-11-01)

Dexmedetomidine infusion as an analgesic adjuvant during laparoscopic сholecystectomy: a randomized controlled study
by: Kateryna Bielka, et al.
Published: (2018-04-01)

Postoperative pain relief following hysterectomy: A randomized controlled trial
by: K P Raghvendra, et al.
Published: (2016-01-01)

Dexmedetomidine versus Dexamethasone as an Adjuvant to Ropivacaine in Transversus Abdominis Plane Block in Infraumbilical Surgeries for Postoperative Analgesia: A Randomised Clinical Study
by: Anupama Kumari, et al.
Published: (2025-01-01)

Effects of Intraoperative Dexmedetomidine Infusion on Postoperative Pain after Craniotomy: A Narrative Review
by: Nesjla Sofia Syrous, et al.
Published: (2021-12-01)

Dexmedetomidine as a part of multimodal analgesia in postoperative period in trauma patients
by: N. V. Kutsevolova, et al.
Published: (2018-12-01)

Reduction in the incidence of postoperative cognitive impairment after hysterectomy with inhalational sevoflurane anesthesia
by: T. I. Akimenko, et al.
Published: (2018-12-01)

Low-dose dexmedetomidine as a perineural adjuvant for postoperative analgesia: a randomized controlled trial
by: Wei Liu, et al.
Published: (2022-08-01)

Dexmedetomidine as an adjunct in postoperative analgesia following cardiac surgery: A randomized, double-blind study
by: Shio Priye, et al.
Published: (2015-01-01)

Intraperitoneal dexmedetomidine as an adjuvant to bupivacaine for postoperative pain management in children undergoing laparoscopic appendectomy: A prospective randomized trial
by: Ali Mohamed Elnabtity, et al.
Published: (2018-01-01)

Intraoperative dexmedetomidine on postoperative sleep disturbance in older patients undergoing major abdominal surgery: A randomized controlled trial protocol
by: Xiu Yang, et al.
Published: (2024-06-01)

Effects of adding dexmedetomidine to local infiltration of bupivacaine on postoperative pain in pediatric herniorrhaphy: a randomized clinical trial
by: Simin Azemati, et al.
Published: (2020-06-01)

Efficacy of dexmedetomidine as an adjuvant in transverse abdominal plane blocks for cesarean section pain management: A systematic review and meta-analysis
by: Dalal Alsultan
Published: (2024-10-01)

Tapentadol Immediate Release (IR) versus Morphine Hydrochloride for Postoperative Analgesia of Patients Undergoing Total Abdominal Hysterectomy—A Prospective Cohort Study
by: Sanja Starčević, et al.
Published: (2023-10-01)

Comparative evaluation of intraoperative dexmedetomidine versus lidocaine for reducing postoperative cognitive decline in the elderly: a prospective randomized controlled trial
by: Mahendran T. Kurup, et al.
Published: (2024-12-01)

Comparison of Local Subcutaneous Infiltration with Ropivacaine Alone and Two Different Doses of Dexmedetomidine Plus Ropivacaine for Postoperative Pain after Cesarean Section Under Spinal Anesthesia
by: Atefeh Ghosouri, et al.
Published: (2025-05-01)

The experience of using dexmedetomidine as an adjuvant of anesthesia in ophthalmic surgery
by: N.V. Mynka, et al.
Published: (2021-03-01)

Efficacy and safety of dexmedetomidine in patients receiving mechanical ventilation: Evidence from randomized controlled trials
by: Qinghua Dong, et al.
Published: (2020-12-01)

Dexmedetomidine for the prevention of postoperative delirium in patients undergoing cardiac surgery: a systematic review and meta-analysis with trial sequential analysis
by: Yiyang Zhong, et al.
Published: (2025-08-01)

Intraperitoneal instillation of ropivacaine plus dexmedetomidine for pain relief after laparoscopic hysterectomy: A comparison with ropivacaine alone
by: Sunil Chiruvella, et al.
Published: (2016-01-01)

Efficacy of intravenous dexmedetomidine versus intraperitoneal dexmedetomidine in laparoscopic cholecystectomy – A prospective randomized double-blinded study
by: Sumati Kandi, et al.
Published: (2022-08-01)

Intrathecal Morphine versus Morphine-Dexmedetomidine Combination for Postoperative Pain Control After Total Knee Replacement: A Randomized Controlled Trial
by: Omara AF, et al.
Published: (2023-08-01)

Impact of different perioperative dexmedetomidine administration regimens on postoperative sleep quality in gastrointestinal tumor resection: a randomized controlled trial
by: Chengying Ji, et al.
Published: (2025-07-01)

A Study to Assess the Efficacy of Ultrasound-guided Bilateral Erector Spinae Plane Block for Total Abdominal Hysterectomy under Spinal Anesthesia: A Prospective Randomized Control Study
by: Ratan Lal Yadav, et al.
Published: (2024-04-01)

Impact of dexmedetomidine on postoperative cognitive dysfunction and inflammatory response in older adult female patients undergoing laparoscopic cholecystectomy
by: Yanlong Fu, et al.
Published: (2025-10-01)

Effect of varying doses of dexmedetomidine added to dexamethasone-enhanced TAPB for post-cesarean pain management
by: Yang Gu, et al.
Published: (2025-07-01)

Effect of perioperative dexmedetomidine on recovery of postoperative gastrointestinal function in patients with general anesthesia: a systematic review and meta-analysis
by: Yanping Liu, et al.
Published: (2024-12-01)

Comparison of the Effect of Adding Dexmedmodine and Fentanyl to Bupivacaine on the Adequacy of Anesthesia and Postoperative Pain in Lumbar Discectomy under Spinal Anesthesia
by: Mohamadali Attari, et al.
Published: (2018-06-01)

Efficacy and safety of intravenous dexmedetomidine as an adjuvant to general anesthesia in gynecological surgeries: A systematic review and meta-analysis of randomized controlled trials
by: Tsung-Yu Hung, et al.
Published: (2023-03-01)

Effect of dexmedetomidine on postoperative sleep quality and complications in women undergoing elective cesarean delivery
by: YOU Yiying, ZHONG Weilong, WANG Yanling, LI Liping
Published: (2025-02-01)

Impact of postoperative dexmedetomidine infusion on incidence of delirium in elderly patients undergoing major elective noncardiac surgery: a randomized clinical trial
by: Sun Y, et al.
Published: (2019-08-01)

The Effect of Adding Dexmedetomidine to Fentanyl for Pain Management after Spinal Fusion Surgery Using Intravenous Patient-Controlled Analgesia Pumps; A Clinical Trial Study
by: Mojtaba Rahimi-Varposhti, et al.
Published: (2019-10-01)

Impact of Postoperative Dexmedetomidine Infusion on Incidence of Delirium in Elderly Patients Undergoing Major Elective Noncardiac Surgery: a Randomized Clinical Trial [Retraction]
by: Sun Y, et al.
Published: (2023-09-01)