Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity

Abstract Background Changes in glycogen metabolism is an essential feature among the various metabolic adaptations used by cancer cells to adjust to the conditions imposed by the tumor microenvironment. Our previous study showed that glycogen branching enzyme (GBE1) is downstream of the HIF1 pathway...

書目詳細資料
發表在:	Molecular Cancer
Main Authors:	Lifeng Li, Li Yang, Shiqi Cheng, Zhirui Fan, Zhibo Shen, Wenhua Xue, Yujia Zheng, Feng Li, Dong Wang, Kai Zhang, Jingyao Lian, Dan Wang, Zijia Zhu, Jie Zhao, Yi Zhang
格式:	Article
語言:	英语
出版:	BMC 2019-06-01
主題:	GBE1 STING pathway Type I interferon T cell infiltration PD-L1 Anti-tumor immunity
在線閱讀:	http://link.springer.com/article/10.1186/s12943-019-1027-x

相似書籍

Development of the A&GBE base editor for efficiently generating abundant genetic variation in rice
由: Wenhui Zhang, et al.
出版: (2024-12-01)

A Synchronic Lexical Study of Gbe Language Varieties: The Effects of Different Similarity Judgment Criteria
由: Angela Kluge
出版: (2005-01-01)

Improvement of the Anticancer Efficacy of PD‐1/PD‐L1 Blockade: Advances in Molecular Mechanisms and Therapeutic Strategies
由: Peng Gao, et al.
出版: (2025-08-01)

Living Donor Liver Transplantation in a Korean Child with Glycogen Storage Disease Type IV and a GBE1 Mutation
出版: (2009-03-01)

Induced pluripotent stem cell (iPSC) modeling validates reduced GBE1 enzyme activity due to a novel variant, p.Ile694Asn, found in a patient with suspected glycogen storage disease IV
由: Chie Naito, et al.
出版: (2024-06-01)

Clinical genetic analysis of an adult polyglucosan body disease (APBD) family caused by the compound heterozygous variant of GBE1 p.R156C and deletion exon 3-7
由: Juan Zhu, et al.
出版: (2025-03-01)

WTAP/IGF2BP3-mediated GBE1 expression accelerates the proliferation and enhances stemness in pancreatic cancer cells via upregulating c-Myc
由: Weiwei Jin, et al.
出版: (2024-07-01)

Medicinal Values and Potential Risks Evaluation of <i>Ginkgo biloba</i> Leaf Extract (GBE) Drinks Made from the Leaves in Autumn as Dietary Supplements
由: Xiaojia Su, et al.
出版: (2022-11-01)

Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses
由: Yu Yu, et al.
出版: (2023-04-01)

STING-Activating Nanoparticles Combined with PD-1/PD-L1 Blockade: A Synergistic Approach in Cancer Immunotherapy
由: Dorota Bartusik-Aebisher, et al.
出版: (2025-09-01)

Identification of copper metabolism-related markers in Parkinson’s disease
由: Jie Lin, et al.
出版: (2024-12-01)

Aberrant Activation of the STING-TBK1 Pathway in γδ T Cells Regulates Immune Responses in Oral Lichen Planus
由: Shan Huang, et al.
出版: (2023-03-01)

Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies
由: Jiawen Zhang, et al.
出版: (2024-01-01)

Targeting STING signaling for the optimal cancer immunotherapy
由: Yan Xu, et al.
出版: (2024-10-01)

Induction of the STING-dependent DNA damage pathway by cucurbitacin B enhances immunotherapy efficacy in osteosarcoma
由: Bin Luo, et al.
出版: (2025-10-01)

High-Speed VCSEL-Based Transceiver for 200 GbE Short-Reach Intra-Datacenter Optical Interconnects
由: Giannis Kanakis, et al.
出版: (2019-06-01)

What goes up must come down: dynamics of type 1 interferon signaling across the lifespan
由: Lucy Hartnell, et al.
出版: (2025-10-01)

COPB1-knockdown induced type I interferon signaling activation inhibits Chlamydia psittaci intracellular proliferation
由: Nana Li, et al.
出版: (2025-03-01)

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression
由: Angel Garcia-Diaz, et al.
出版: (2017-05-01)

Advanced Cancer Immunotherapy via SMARCAL1 Blockade Using a Glucose‐Responsive CRISPR Nanovaccine
由: Yuwei Li, et al.
出版: (2025-10-01)

The Potential of PD-1 and PD-L1 as Prognostic and Predictive Biomarkers in Colorectal Adenocarcinoma Based on TILs Grading
由: Nur Rahmah Rasyid, et al.
出版: (2024-11-01)

Verteporfin inhibits the cGAS-STING pathway and improves the tumor microenvironment during cisplatin treatment in hepatocellular carcinoma
由: Yi Gong, et al.
出版: (2025-08-01)

Tupaia GBP1 exploits autophagy to restrict herpes simplex virus type 1 infection
由: Tianle Gu, et al.
出版: (2022-12-01)

Língua Geral de Mina: uma fotografia da história linguística dos africanos escravizados no Brasil
由: Wellington Santos da Silva
出版: (2023-04-01)

Pembrolizumab Versus High-Dose Interferon-α2b as Adjuvant Therapy for Pediatric Melanoma: A Retrospective Study
由: Yu Du, et al.
出版: (2024-01-01)

LC-MS based untargeted metabolomics studies of the metabolic response of Ginkgo biloba extract on arsenism patients
由: Weiwei Li, et al.
出版: (2024-04-01)

Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis
由: Nengwen Xia, et al.
出版: (2022-10-01)

Porcine cGAS-STING signalling induced apoptosis negatively regulates STING downstream IFN response and autophagy via different mechanisms
由: Nengwen Xia, et al.
出版: (2025-12-01)

STING controls opioid-induced itch and chronic itch via spinal tank-binding kinase 1-dependent type I interferon response in mice
由: Nan Li, et al.
出版: (2023-04-01)

Tumor microenvironment and drug resistance in lung adenocarcinoma: molecular mechanisms, prognostic implications, and therapeutic strategies
由: Qianqian Cao, et al.
出版: (2025-02-01)

Prognostic implications of immune classification based on PD-L1 expression and tumor-infiltrating lymphocytes in endocervical adenocarcinoma
由: Li-Jun Wei, et al.
出版: (2025-02-01)

Phenotypic spectrum in recessive STING-associated vasculopathy with onset in infancy: Four novel cases and analysis of previously reported cases
由: Rensheng Wan, et al.
出版: (2022-10-01)

Differentiation status determines the effects of IFNγ on the expression of PD-L1 and immunomodulatory genes in melanoma
由: Teitur Sævarsson, et al.
出版: (2024-12-01)

Cytosolic DNA sensors in neurodegenerative diseases: from physiological defenders to pathological culprits
由: Jiatian Xie, et al.
出版: (2024-03-01)

Tetrandrine activates STING/TBK1/IRF3 pathway to potentiate anti-PD-1 immunotherapy efficacy in non-small cell lung cancer
由: Yan Tan, et al.
出版: (2024-09-01)

FBXO38 deficiency promotes lysosome-dependent STING degradation and inhibits cGAS–STING pathway activation
由: Yijia Wu, et al.
出版: (2024-03-01)

Uniportal VATS Treatment of Giant Bullous Emphysema: Is It Safe and Effective?
由: Antonio Giulio Napolitano, et al.
出版: (2025-03-01)

Relationship between consolidation tumor ratio and tumor‐infiltrating lymphocytes in small‐sized lung adenocarcinoma
由: Yuki Ono, et al.
出版: (2022-08-01)

In Vitro Effects of Sulforaphane on Interferon-Driven Inflammation and Exploratory Evaluation in Two Healthy Volunteers
由: Elena Genova, et al.
出版: (2021-06-01)

Low Expression of Programmed Death 1 (PD-1), PD-1 Ligand 1 (PD-L1), and Low CD8+ T Lymphocyte Infiltration Identify a Subgroup of Patients With Gastric and Esophageal Adenocarcinoma With Severe Prognosis
由: Silvio Däster, et al.
出版: (2020-04-01)