Revealing the intercellular communication changes of human abdominal aortic aneurysms at single-cell resolution
Background: Abdominal aortic aneurysm (AAA) is a chronic vascular inflammation progression with a high mortality. However, intercellular communication has not been sufficiently explored in human AAA tissue. Aims: Here, we investigated available single-cell RNA sequencing data generated from human AA...
| Published in: | Indian Journal of Vascular and Endovascular Surgery |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
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| Subjects: | |
| Online Access: | http://www.indjvascsurg.org/article.asp?issn=0972-0820;year=2023;volume=10;issue=4;spage=253;epage=264;aulast=Niu |
| Summary: | Background: Abdominal aortic aneurysm (AAA) is a chronic vascular inflammation progression with a high mortality. However, intercellular communication has not been sufficiently explored in human AAA tissue. Aims: Here, we investigated available single-cell RNA sequencing data generated from human AAA. Results: These cells were divided into 27 clusters and 6 main cell types, such as T-cells, B-cells, myeloid cells, neutrophils, endothelial cells, and fibroblasts. Immune cells were present in AAA tissues more than control. In addition, we established an intercellular communication network and observed a more pronounced enrichment of TGFB1, CCL, VEGF, IL6, and complement pathways in the AAA group compared to the control group. Conclusion: Together, our analyses provide beneficial insight into cell–cell communication and expand channels for the effective immunotherapy development of AAA in the future. |
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| ISSN: | 0972-0820 2394-0999 |