Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling

Tissue engineering-based therapies targeting cartilage diseases, such as osteoarthritis, require in vitro expansion of articular chondrocytes. A major obstacle for these therapies is the dedifferentiation and loss of phenotype accompanying chondrocyte expansion. Recent studies suggest that manipulat...

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Bibliographic Details
Published in:European Cells & Materials
Main Authors: CL Thompson, JCT Plant, AKT Wann, CL Bishop, P Novak, HM Mitchison, PL Beales, JP Chapple, MM Knight
Format: Article
Language:English
Published: Forum Multimedia Publishing LLC 2017-09-01
Subjects:
Chondrocyte
dedifferentiation
re-differentiation
primary cilia
cilium
hedgehog
lithium chloride
Online Access:http://www.ecmjournal.org/papers/vol034/pdf/v034a09.pdf

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