Coronavirus Inhibitors Targeting nsp16
During the past three decades, humans have been confronted with different new coronavirus outbreaks. Since the end of the year 2019, COVID-19 threatens the world as a rapidly spreading infectious disease. For this work, we targeted the non-structural protein 16 (nsp16) as a key protein of SARS-CoV-2...
| Published in: | Molecules |
|---|---|
| Main Authors: | Ejlal A. Omer, Sara Abdelfatah, Max Riedl, Christian Meesters, Andreas Hildebrandt, Thomas Efferth |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/3/988 |
Similar Items
In Silico Design of Peptide-Based SARS-CoV-2 Fusion Inhibitors That Target WT and Mutant Versions of SARS-CoV-2 HR1 Domains
by: Shana V. Stoddard, et al.
Published: (2021-07-01)
by: Shana V. Stoddard, et al.
Published: (2021-07-01)
Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and Nsp13 helicase
by: Muhammad Usman Mirza, et al.
Published: (2020-08-01)
by: Muhammad Usman Mirza, et al.
Published: (2020-08-01)
LMP7 as a Target for Coronavirus Therapy: Inhibition by Ixazomib and Interaction with SARS-CoV-2 Proteins Nsp13 and Nsp16
by: Yi Ru, et al.
Published: (2025-09-01)
by: Yi Ru, et al.
Published: (2025-09-01)
3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors
by: Olga Bobileva, et al.
Published: (2023-01-01)
by: Olga Bobileva, et al.
Published: (2023-01-01)
The interplay between emerging human coronavirus infections and autophagy
by: Zhenyu Zhao, et al.
Published: (2021-01-01)
by: Zhenyu Zhao, et al.
Published: (2021-01-01)
SARS-CoV-2 and Coronaviruses: Understanding Transmission, Impact, and Strategies for Prevention and Treatment
by: Seyede Nafise Tabatabaei, et al.
Published: (2025-02-01)
by: Seyede Nafise Tabatabaei, et al.
Published: (2025-02-01)
The Comparative Immunological Characteristics of SARS-CoV, MERS-CoV, and SARS-CoV-2 Coronavirus Infections
by: Yun-yu Zhang, et al.
Published: (2020-08-01)
by: Yun-yu Zhang, et al.
Published: (2020-08-01)
The relation between avian coronaviruses and SARS-CoV-2 coronavirus
by: Hanan Al-Khalaifah, et al.
Published: (2022-10-01)
by: Hanan Al-Khalaifah, et al.
Published: (2022-10-01)
Contribution to pathogenesis of accessory proteins of deadly human coronaviruses
by: Jesus Hurtado-Tamayo, et al.
Published: (2023-05-01)
by: Jesus Hurtado-Tamayo, et al.
Published: (2023-05-01)
The biological diversity of coronaviruses: where will the new threat come from?
by: Alexandr Khaitovich, et al.
Published: (2022-05-01)
by: Alexandr Khaitovich, et al.
Published: (2022-05-01)
Structure-Based Virtual Screening for Methyltransferase Inhibitors of SARS-CoV-2 nsp14 and nsp16
by: Kejue Wu, et al.
Published: (2024-05-01)
by: Kejue Wu, et al.
Published: (2024-05-01)
A Novel Frameshifting Inhibitor Having Antiviral Activity against Zoonotic Coronaviruses
by: Dae-Gyun Ahn, et al.
Published: (2021-08-01)
by: Dae-Gyun Ahn, et al.
Published: (2021-08-01)
Coronaviruses: Is Sialic Acid a Gate to the Eye of Cytokine Storm? From the Entry to the Effects
by: Przemyslaw Wielgat, et al.
Published: (2020-08-01)
by: Przemyslaw Wielgat, et al.
Published: (2020-08-01)
Antiviral Potential of <i>Antillogorgia americana</i> and <i>elisabethae</i> Natural Products against nsp16–nsp10 Complex, nsp13, and nsp14 Proteins of SARS-CoV-2: An In Silico Investigation
by: Omkar Pokharkar, et al.
Published: (2023-07-01)
by: Omkar Pokharkar, et al.
Published: (2023-07-01)
Commentary: Origin and evolution of pathogenic coronaviruses
by: Shun Adachi, et al.
Published: (2020-04-01)
by: Shun Adachi, et al.
Published: (2020-04-01)
Insight into 2019 novel coronavirus — An updated interim review and lessons from SARS-CoV and MERS-CoV
by: Mingxuan Xie, et al.
Published: (2020-05-01)
by: Mingxuan Xie, et al.
Published: (2020-05-01)
An Overview of the Pathogenesis, Transmission, Diagnosis, and Management of Endemic Human Coronaviruses: A Reflection on the Past and Present Episodes and Possible Future Outbreaks
by: Adeoye J. Kayode, et al.
Published: (2021-08-01)
by: Adeoye J. Kayode, et al.
Published: (2021-08-01)
Development of Coronavirus Treatments Using Neutralizing Antibodies
by: Saman Fouladirad, et al.
Published: (2021-01-01)
by: Saman Fouladirad, et al.
Published: (2021-01-01)
SARS-CoV-2, the other face to SARS-CoV and MERS-CoV: Future predictions
by: T.M. Abdelghany, et al.
Published: (2021-03-01)
by: T.M. Abdelghany, et al.
Published: (2021-03-01)
Coronavirus Antiviral Research Database (CoV-RDB): An Online Database Designed to Facilitate Comparisons between Candidate Anti-Coronavirus Compounds
by: Philip L. Tzou, et al.
Published: (2020-09-01)
by: Philip L. Tzou, et al.
Published: (2020-09-01)
Discovery of Highly Potent Small Molecule Pan-Coronavirus Fusion Inhibitors
by: Francesca Curreli, et al.
Published: (2023-04-01)
by: Francesca Curreli, et al.
Published: (2023-04-01)
Evolutionary Dynamics and Epidemiology of Endemic and Emerging Coronaviruses in Humans, Domestic Animals, and Wildlife
by: Ariful Islam, et al.
Published: (2021-09-01)
by: Ariful Islam, et al.
Published: (2021-09-01)
Localization of SARS-CoV-2 Capping Enzymes Revealed by an Antibody against the nsp10 Subunit
by: Vladimira Horova, et al.
Published: (2021-07-01)
by: Vladimira Horova, et al.
Published: (2021-07-01)
Nucleoside Analogs and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other Coronaviruses
by: Nicola Borbone, et al.
Published: (2021-02-01)
by: Nicola Borbone, et al.
Published: (2021-02-01)
Computational Investigation of Structural Dynamics of SARS-CoV-2 Methyltransferase-Stimulatory Factor Heterodimer nsp16/nsp10 Bound to the Cofactor SAM
by: Md Fulbabu Sk, et al.
Published: (2020-11-01)
by: Md Fulbabu Sk, et al.
Published: (2020-11-01)
The Differences in the Evolutionary Dynamics of MERS and SARS Coronaviruses
by: Yushan Ding, et al.
Published: (2025-08-01)
by: Yushan Ding, et al.
Published: (2025-08-01)
Autopsy Tool in Unknown Diseases: The Experience with Coronaviruses (SARS-CoV, MERS-CoV, SARS-CoV-2)
by: Francesco Sessa, et al.
Published: (2021-03-01)
by: Francesco Sessa, et al.
Published: (2021-03-01)
Comment on Alfassam et al. Development of a Colorimetric Tool for SARS-CoV-2 and Other Respiratory Viruses Detection Using Sialic Acid Fabricated Gold Nanoparticles. <i>Pharmaceutics</i> 2021, <i>13</i>, 502
by: Milad Zandi, et al.
Published: (2022-09-01)
by: Milad Zandi, et al.
Published: (2022-09-01)
From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses
by: Zhixing Zhu, et al.
Published: (2020-08-01)
by: Zhixing Zhu, et al.
Published: (2020-08-01)
Potential Immunogenic Activity of Computationally Designed mRNA- and Peptide-Based Prophylactic Vaccines against MERS, SARS-CoV, and SARS-CoV-2: A Reverse Vaccinology Approach
by: Taimoor Khan, et al.
Published: (2022-04-01)
by: Taimoor Khan, et al.
Published: (2022-04-01)
Comparison and Analysis of Neutralizing Antibody Levels in Serum after Inoculating with SARS-CoV-2, MERS-CoV, or SARS-CoV Vaccines in Humans
by: Sicong Yu, et al.
Published: (2021-06-01)
by: Sicong Yu, et al.
Published: (2021-06-01)
Recent Chronology of COVID-19 Pandemic
by: Sazada Siddiqui, et al.
Published: (2022-05-01)
by: Sazada Siddiqui, et al.
Published: (2022-05-01)
Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16
by: Huan Wang, et al.
Published: (2023-12-01)
by: Huan Wang, et al.
Published: (2023-12-01)
Assay development and screening of inhibitors targeting the SARS-CoV-2 2′-O-methyltransferase NSP16
by: Mengtong Cao, et al.
Published: (2025-12-01)
by: Mengtong Cao, et al.
Published: (2025-12-01)
Feasibility of Known RNA Polymerase Inhibitors as Anti-SARS-CoV-2 Drugs
by: Ujjwal Neogi, et al.
Published: (2020-04-01)
by: Ujjwal Neogi, et al.
Published: (2020-04-01)
Plant Molecular Pharming and Plant-Derived Compounds towards Generation of Vaccines and Therapeutics against Coronaviruses
by: Srividhya Venkataraman
Published: (2022-10-01)
by: Srividhya Venkataraman
Published: (2022-10-01)
Molecular docking and pharmacokinetic studies of phytocompounds from Nigerian Medicinal Plants as promising inhibitory agents against SARS-CoV-2 methyltransferase (nsp16)
by: Tolulope Peter Saliu, et al.
Published: (2021-11-01)
by: Tolulope Peter Saliu, et al.
Published: (2021-11-01)
Unraveling the Epidemiology, Geographical Distribution, and Genomic Evolution of Potentially Lethal Coronaviruses (SARS, MERS, and SARS CoV-2)
by: Nosheen Masood, et al.
Published: (2020-08-01)
by: Nosheen Masood, et al.
Published: (2020-08-01)
Discovery of SARS-CoV-2 Nsp14 and Nsp16 Methyltransferase Inhibitors by High-Throughput Virtual Screening
by: Raitis Bobrovs, et al.
Published: (2021-11-01)
by: Raitis Bobrovs, et al.
Published: (2021-11-01)
Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays
by: Francesca Curreli, et al.
Published: (2021-12-01)
by: Francesca Curreli, et al.
Published: (2021-12-01)
Similar Items
-
In Silico Design of Peptide-Based SARS-CoV-2 Fusion Inhibitors That Target WT and Mutant Versions of SARS-CoV-2 HR1 Domains
by: Shana V. Stoddard, et al.
Published: (2021-07-01) -
Structural elucidation of SARS-CoV-2 vital proteins: Computational methods reveal potential drug candidates against main protease, Nsp12 polymerase and Nsp13 helicase
by: Muhammad Usman Mirza, et al.
Published: (2020-08-01) -
LMP7 as a Target for Coronavirus Therapy: Inhibition by Ixazomib and Interaction with SARS-CoV-2 Proteins Nsp13 and Nsp16
by: Yi Ru, et al.
Published: (2025-09-01) -
3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors
by: Olga Bobileva, et al.
Published: (2023-01-01) -
The interplay between emerging human coronavirus infections and autophagy
by: Zhenyu Zhao, et al.
Published: (2021-01-01)
