Altering rRNA 2’O-methylation pattern during neuronal differentiation is regulated by FMRP

The Fragile X Messenger Ribonucleoprotein (FMRP) is a selective RNA-binding protein that localizes to the cytoplasm and the nucleus. The loss of FMRP results in Fragile X Syndrome (FXS), an autism spectrum disorder. FMRP interacts with ribosomes and regulates the translation of mRNAs essential for n...

Full description

Bibliographic Details
Published in:	RNA Biology
Main Authors:	Michelle Ninochka D’Souza, Naveen Kumar Chandappa Gowda, Nivedita Hariharan, Syed Wasifa Qadri, Dasaradhi Palakodeti, Ravi S Muddashetty
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	FMRP ribosome snoRNA epitranscriptome Ribosomal RNA
Online Access:	https://www.tandfonline.com/doi/10.1080/15476286.2025.2563986

Similar Items

How Cancer Exploits Ribosomal RNA Biogenesis: A Journey beyond the Boundaries of rRNA Transcription
by: Marco Gaviraghi, et al.
Published: (2019-09-01)

Small but Mighty—The Emerging Role of snoRNAs in Hematological Malignancies
by: Jaime Calvo Sánchez, et al.
Published: (2021-10-01)

Site-specific analysis of ribosomal 2′O-methylation by quantitative reverse transcription PCR under low deoxynucleotide triphosphate concentrations
by: Daniela Barros-Silva, et al.
Published: (2023-05-01)

Ribosomal RNA Pseudouridylation: Will Newly Available Methods Finally Define the Contribution of This Modification to Human Ribosome Plasticity?
by: Chiara Barozzi, et al.
Published: (2022-06-01)

Adaptation of the protein translational apparatus during ATDC5 chondrogenic differentiation
by: Mandy M.F. Steinbusch, et al.
Published: (2022-06-01)

Computational limitations and future needs to unravel the full potential of 2’-O-methylation and C/D box snoRNAs
by: Christian Ramirez, et al.
Published: (2025-12-01)

Small nucleolar RNA dysregulation and potential roles in bovine subclinical mastitis
by: Faith A. Omonijo, et al.
Published: (2025-09-01)

The Conserved RNA Exonuclease Rexo5 Is Required for 3′ End Maturation of 28S rRNA, 5S rRNA, and snoRNAs
by: Stefanie Gerstberger, et al.
Published: (2017-10-01)

Nucleolar Structure and Function in Trypanosomatid Protozoa
by: Santiago Martínez-Calvillo, et al.
Published: (2019-05-01)

SnoRNA in Cancer Progression, Metastasis and Immunotherapy Response
by: Jildou van der Werf, et al.
Published: (2021-08-01)

snoRNPs: Functions in Ribosome Biogenesis
by: Sandeep Ojha, et al.
Published: (2020-05-01)

Small Nucleolar (Sno)RNA: Therapy Lays in Translation
by: Ofri Rabany, et al.
Published: (2023-06-01)

Plant ribosomes as a score to fathom the melody of 2’-O-methylation across evolution
by: Sara Alina Neumann, et al.
Published: (2024-12-01)

Epitranscriptome and FMRP Regulated mRNA Translation
by: Pritha Majumder, et al.
Published: (2017-07-01)

The catalytic activity of methyltransferase METTL15 is dispensable for its role in mitochondrial ribosome biogenesis
by: Christian D. Mutti, et al.
Published: (2024-12-01)

RNA folding and functions of RNA helicases in ribosome biogenesis
by: Valentin Mitterer, et al.
Published: (2022-12-01)

ZNHIT3 Regulates Translation to Ensure Cell Lineage Differentiation in Mouse Preimplantation Development
by: Guanghui Yang, et al.
Published: (2025-06-01)

Maturation of small nucleolar RNAs: from production to function
by: Sarah F. Webster, et al.
Published: (2023-12-01)

Disruption of the RNA modifications that target the ribosome translation machinery in human cancer
by: Maxime Janin, et al.
Published: (2020-04-01)

Exploring the roles of snoRNA-induced ribosome heterogeneity in equine osteoarthritis
by: Alzbeta Chabronova, et al.
Published: (2025-07-01)

Cl gene cluster encoding several small nucleolar RNAs: a comparison amongst trypanosomatids
by: Paola Nocua, et al.
Published: (2009-05-01)

The regulatory roles of small nucleolar RNAs within their host locus
by: Étienne Fafard-Couture, et al.
Published: (2024-12-01)

Annotation of snoRNA abundance across human tissues reveals complex snoRNA-host gene relationships
by: Étienne Fafard-Couture, et al.
Published: (2021-06-01)

Manipulation of Cellular Processes via Nucleolus Hijaking in the Course of Viral Infection in Mammals
by: Olga V. Iarovaia, et al.
Published: (2021-06-01)

Differential expression of snoRNAs in oral squamous cell carcinomas: new potential diagnostic markers
by: Cintia Chamorro-Petronacci, et al.
Published: (2018-01-01)

Regulation of the U3-, U8-, and U13snoRNA Expression by the DEAD Box Proteins Ddx5/Ddx17 with Consequences for Cell Proliferation and Survival
by: Hala Ismael, et al.
Published: (2016-09-01)

SnoRNAs: The promising targets for anti-tumor therapy
by: Xiaoyun Hu, et al.
Published: (2024-11-01)

Human RPF1 and ESF1 in Pre-rRNA Processing and the Assembly of Pre-Ribosomal Particles: A Functional Study
by: Alexander Deryabin, et al.
Published: (2024-02-01)

Visualizing the Role of 2’-OH rRNA Methylations in the Human Ribosome Structure
by: S. Kundhavai Natchiar, et al.
Published: (2018-10-01)

Small nucleolar RNA SNORD13H suppresses tumor progression via FBL-dependent 2′-O-methylation in hepatocellular carcinoma
by: Minglu Zhang, et al.
Published: (2025-08-01)

Synergistic interaction network between the snR30 RNP, Utp23, and ribosomal RNA during ribosome synthesis
by: Timothy J. Vos, et al.
Published: (2022-12-01)

Intronic small nucleolar RNAs regulate host gene splicing through base pairing with their adjacent intronic sequences
by: Danny Bergeron, et al.
Published: (2023-07-01)

Identification of a novel nine‐SnoRNA signature with potential prognostic and therapeutic value in ovarian cancer
by: Wenjing Zhu, et al.
Published: (2022-05-01)

HMGB1 prefers to interact with structural RNAs and regulates rRNA methylation modification and translation in HeLa cells
by: Meimei Liao, et al.
Published: (2024-04-01)

The Host Non-Coding RNA Response to Alphavirus Infection
by: Mahgol Behnia, et al.
Published: (2023-02-01)

Crosstalk between ubiquitination and translation in neurodevelopmental disorders
by: Nagore Elu, et al.
Published: (2024-09-01)

Non-coding RNAs in oral cancer: Emerging biomarkers and therapeutic frontier
by: Mehrdad Hashemi, et al.
Published: (2024-11-01)

A contemporary review of snoRNAs in cardiovascular health: RNA modification and beyond
by: Noah Peter Jagielski, et al.
Published: (2024-03-01)

snoRNAs Offer Novel Insight and Promising Perspectives for Lung Cancer Understanding and Management
by: Nour-El-Houda Mourksi, et al.
Published: (2020-02-01)

Human nucleolar protein 7 (NOL7) is required for early pre-rRNA accumulation and pre-18S rRNA processing
by: Mason A. McCool, et al.
Published: (2023-12-01)