DOWNSTREAM PROCESS OF BIOPHARMACEUTICALS
The development of the biopharmaceuticals begins with the development of effective producers. But the more complex protein and its producer, the greater the amount of impurities is synthesized or accumulated during the upstream process. Among them are as follows: bacterial endotoxins, viruses, host...
| Published in: | Разработка и регистрация лекарственных средств |
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| Main Author: | |
| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/294 |
| Summary: | The development of the biopharmaceuticals begins with the development of effective producers. But the more complex protein and its producer, the greater the amount of impurities is synthesized or accumulated during the upstream process. Among them are as follows: bacterial endotoxins, viruses, host cell proteins, related impurities, aggregates and high molecular weight admixtures etc. This article describes approaches to the downstream process purification of biopharmaceutical proteins. We discuss the main chromatography and non-chromatographical methods. |
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| ISSN: | 2305-2066 2658-5049 |