Autophagy Modulation and Its Implications on Glioblastoma Treatment
Autophagy is a vital cellular process that functions to degrade and recycle damaged organelles into basic metabolites. This allows a cell to adapt to a diverse range of challenging conditions. Autophagy assists in maintaining homeostasis, and it is tightly regulated by the cell. The disruption of au...
| Published in: | Current Issues in Molecular Biology |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
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| Subjects: | |
| Online Access: | https://www.mdpi.com/1467-3045/45/11/546 |
| _version_ | 1850345571586408448 |
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| author | Johnny Chen Andrea Salinas Rodriguez Maximiliano Arath Morales Xiaoqian Fang |
| author_facet | Johnny Chen Andrea Salinas Rodriguez Maximiliano Arath Morales Xiaoqian Fang |
| author_sort | Johnny Chen |
| collection | DOAJ |
| container_title | Current Issues in Molecular Biology |
| description | Autophagy is a vital cellular process that functions to degrade and recycle damaged organelles into basic metabolites. This allows a cell to adapt to a diverse range of challenging conditions. Autophagy assists in maintaining homeostasis, and it is tightly regulated by the cell. The disruption of autophagy has been associated with many diseases, such as neurodegenerative disorders and cancer. This review will center its discussion on providing an in-depth analysis of the current molecular understanding of autophagy and its relevance to brain tumors. We will delve into the current literature regarding the role of autophagy in glioma pathogenesis by exploring the major pathways of JAK2/STAT3 and PI3K/AKT/mTOR and summarizing the current therapeutic interventions and strategies for glioma treatment. These treatments will be evaluated on their potential for autophagy induction and the challenges associated with their utilization. By understanding the mechanism of autophagy, clinical applications for future therapeutics in treating gliomas can be better targeted. |
| format | Article |
| id | doaj-art-e22735d0e2eb4e54914a2790c14c10ca |
| institution | Directory of Open Access Journals |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-e22735d0e2eb4e54914a2790c14c10ca2025-08-19T23:12:16ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452023-10-0145118687870310.3390/cimb45110546Autophagy Modulation and Its Implications on Glioblastoma TreatmentJohnny Chen0Andrea Salinas Rodriguez1Maximiliano Arath Morales2Xiaoqian Fang3Department of Neuroscience, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX 78539, USADepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Edinburg, TX 78539, USADepartment of Biology, College of Science, University of Texas Rio Grande Valley, Edinburg, TX 78539, USADepartment of Neuroscience, School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX 78539, USAAutophagy is a vital cellular process that functions to degrade and recycle damaged organelles into basic metabolites. This allows a cell to adapt to a diverse range of challenging conditions. Autophagy assists in maintaining homeostasis, and it is tightly regulated by the cell. The disruption of autophagy has been associated with many diseases, such as neurodegenerative disorders and cancer. This review will center its discussion on providing an in-depth analysis of the current molecular understanding of autophagy and its relevance to brain tumors. We will delve into the current literature regarding the role of autophagy in glioma pathogenesis by exploring the major pathways of JAK2/STAT3 and PI3K/AKT/mTOR and summarizing the current therapeutic interventions and strategies for glioma treatment. These treatments will be evaluated on their potential for autophagy induction and the challenges associated with their utilization. By understanding the mechanism of autophagy, clinical applications for future therapeutics in treating gliomas can be better targeted.https://www.mdpi.com/1467-3045/45/11/546autophagyglioblastomatreatmentJAK2/STAT3 signaling pathwayPI3K/AKT/mTOR signaling pathway |
| spellingShingle | Johnny Chen Andrea Salinas Rodriguez Maximiliano Arath Morales Xiaoqian Fang Autophagy Modulation and Its Implications on Glioblastoma Treatment autophagy glioblastoma treatment JAK2/STAT3 signaling pathway PI3K/AKT/mTOR signaling pathway |
| title | Autophagy Modulation and Its Implications on Glioblastoma Treatment |
| title_full | Autophagy Modulation and Its Implications on Glioblastoma Treatment |
| title_fullStr | Autophagy Modulation and Its Implications on Glioblastoma Treatment |
| title_full_unstemmed | Autophagy Modulation and Its Implications on Glioblastoma Treatment |
| title_short | Autophagy Modulation and Its Implications on Glioblastoma Treatment |
| title_sort | autophagy modulation and its implications on glioblastoma treatment |
| topic | autophagy glioblastoma treatment JAK2/STAT3 signaling pathway PI3K/AKT/mTOR signaling pathway |
| url | https://www.mdpi.com/1467-3045/45/11/546 |
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