Closing the loops: chromatin loop dynamics after DNA damage
Chromatin is a dynamic polymer in constant motion. These motions are heterogeneous between cells and within individual cell nuclei and are profoundly altered in response to DNA damage. The shifts in chromatin motions following genomic insults depend on the temporal and physical scales considered. Th...
| Published in: | Nucleus |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
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| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19491034.2024.2438633 |
| _version_ | 1849705125013094400 |
|---|---|
| author | Pierre-Alexandre Vidi Jing Liu Keith Bonin Kerry Bloom |
| author_facet | Pierre-Alexandre Vidi Jing Liu Keith Bonin Kerry Bloom |
| author_sort | Pierre-Alexandre Vidi |
| collection | DOAJ |
| container_title | Nucleus |
| description | Chromatin is a dynamic polymer in constant motion. These motions are heterogeneous between cells and within individual cell nuclei and are profoundly altered in response to DNA damage. The shifts in chromatin motions following genomic insults depend on the temporal and physical scales considered. They are also distinct in damaged and undamaged regions. In this review, we emphasize the role of chromatin tethering and loop formation in chromatin dynamics, with the view that pulsing loops are key contributors to chromatin motions. Chromatin tethers likely mediate micron-scale chromatin coherence predicted by polymer models and measured experimentally, and we propose that remodeling of the tethers in response to DNA breaks enables uncoupling of damaged and undamaged chromatin regions. |
| format | Article |
| id | doaj-art-e22e56ea3d0a4440891c1d70af46e552 |
| institution | Directory of Open Access Journals |
| issn | 1949-1034 1949-1042 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| spelling | doaj-art-e22e56ea3d0a4440891c1d70af46e5522025-08-20T02:00:17ZengTaylor & Francis GroupNucleus1949-10341949-10422025-12-0116110.1080/19491034.2024.2438633Closing the loops: chromatin loop dynamics after DNA damagePierre-Alexandre Vidi0Jing Liu1Keith Bonin2Kerry Bloom3Laboratoire InGenO, Institut de Cancérologie de l’Ouest, Angers, FranceDepartment of Physics and Astronomy, Purdue University, West Lafayette, IN, USADepartment of Physics, Wake Forest University, Winston-Salem, NC, USADepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USAChromatin is a dynamic polymer in constant motion. These motions are heterogeneous between cells and within individual cell nuclei and are profoundly altered in response to DNA damage. The shifts in chromatin motions following genomic insults depend on the temporal and physical scales considered. They are also distinct in damaged and undamaged regions. In this review, we emphasize the role of chromatin tethering and loop formation in chromatin dynamics, with the view that pulsing loops are key contributors to chromatin motions. Chromatin tethers likely mediate micron-scale chromatin coherence predicted by polymer models and measured experimentally, and we propose that remodeling of the tethers in response to DNA breaks enables uncoupling of damaged and undamaged chromatin regions.https://www.tandfonline.com/doi/10.1080/19491034.2024.2438633Chromatin coherencechromatin motionscohesinDNA damageloopstethers |
| spellingShingle | Pierre-Alexandre Vidi Jing Liu Keith Bonin Kerry Bloom Closing the loops: chromatin loop dynamics after DNA damage Chromatin coherence chromatin motions cohesin DNA damage loops tethers |
| title | Closing the loops: chromatin loop dynamics after DNA damage |
| title_full | Closing the loops: chromatin loop dynamics after DNA damage |
| title_fullStr | Closing the loops: chromatin loop dynamics after DNA damage |
| title_full_unstemmed | Closing the loops: chromatin loop dynamics after DNA damage |
| title_short | Closing the loops: chromatin loop dynamics after DNA damage |
| title_sort | closing the loops chromatin loop dynamics after dna damage |
| topic | Chromatin coherence chromatin motions cohesin DNA damage loops tethers |
| url | https://www.tandfonline.com/doi/10.1080/19491034.2024.2438633 |
| work_keys_str_mv | AT pierrealexandrevidi closingtheloopschromatinloopdynamicsafterdnadamage AT jingliu closingtheloopschromatinloopdynamicsafterdnadamage AT keithbonin closingtheloopschromatinloopdynamicsafterdnadamage AT kerrybloom closingtheloopschromatinloopdynamicsafterdnadamage |