MDSCs in breast cancer: an important enabler of tumor progression and an emerging therapeutic target

Women worldwide are more likely to develop breast cancer (BC) than any other type of cancer. The treatment of BC depends on the subtype and stage of the cancer, such as surgery, radiotherapy, chemotherapy, and immunotherapy. Although significant progress has been made in recent years, advanced or me...

Full description

Bibliographic Details
Published in:	Frontiers in Immunology
Main Authors:	Haoyu Liu, Zhicheng Wang, Yuntao Zhou, Yanming Yang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-07-01
Subjects:	myeloid-derived suppressor cells breast cancer immunosuppression immunotherapy tumor microenvironments
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1199273/full

Similar Items

Research progress of MDSCs-targeted immunotherapy for pancreatic cancer
by: QIN Yahan, et al.
Published: (2023-10-01)

Immunotherapy of targeting MDSCs in tumor microenvironment
by: Hongshu Sui, et al.
Published: (2022-09-01)

The Role of Myeloid-Derived Suppressor Cells (MDSCs) in the Development and/or Progression of Endometriosis-State of the Art
by: Dorota Suszczyk, et al.
Published: (2021-03-01)

Immunotherapy Targeting Myeloid-Derived Suppressor Cells (MDSCs) in Tumor Microenvironment
by: Xidan Gao, et al.
Published: (2021-02-01)

Myeloid-derived suppressor cells: key immunosuppressive regulators and therapeutic targets in hematological malignancies
by: Shifen Wang, et al.
Published: (2023-03-01)

Novel therapeutic strategies targeting myeloid-derived suppressor cell immunosuppressive mechanisms for cancer treatment
by: Eric Jou, et al.
Published: (2024-02-01)

Immunosuppression in Glioblastoma: Current Understanding and Therapeutic Implications
by: Benjamin T. Himes, et al.
Published: (2021-10-01)

Evolution of our understanding of myeloid regulatory cells: from MDSCs to Mregs
by: Masoud H Manjili, et al.
Published: (2014-07-01)

The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression
by: Viktor Umansky, et al.
Published: (2016-11-01)

Clinical Relevance and Immunosuppressive Pattern of Circulating and Infiltrating Subsets of Myeloid-Derived Suppressor Cells (MDSCs) in Epithelial Ovarian Cancer
by: Karolina Okła, et al.
Published: (2019-04-01)

Myeloid-derived suppressor cells in gliomas
by: Anna Gieryng, et al.
Published: (2016-12-01)

Myeloid-Derived Suppressor Cells (MDSCs) in Ovarian Cancer—Looking Back and Forward
by: Karolina Okła
Published: (2023-07-01)

A Complex Metabolic Network Confers Immunosuppressive Functions to Myeloid-Derived Suppressor Cells (MDSCs) within the Tumour Microenvironment
by: Francesca Hofer, et al.
Published: (2021-10-01)

Modulation of T-cell function by myeloid-derived suppressor cells in hematological malignancies
by: Vaishali Bhardwaj, et al.
Published: (2023-04-01)

PKM2 orchestrates tumor progression via metabolic reprogramming and MDSCs-mediated immune suppression in the tumor microenvironment
by: Wenxi Liu, et al.
Published: (2025-08-01)

Immunomodulatory role of MDSCs during the neonatal period
by: Dong Rui, et al.
Published: (2024-06-01)

The Function and Therapeutic Implications of TNF Signaling in MDSCs
by: Kun Yu, et al.
Published: (2022-11-01)

Advances in Anti-tumor Therapy of Myeloid-derived Suppressor Cells Combined with Immunological Checkpoint Inhibitors
by: SUN Haiyan, et al.
Published: (2020-09-01)

Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment
by: Xinyu Tian, et al.
Published: (2019-08-01)

Aging modulates the immunosuppressive, polarizing and metabolic functions of blood-derived myeloid-derived suppressor cells (MDSCs)
by: Emma Keltsch, et al.
Published: (2025-07-01)

mTOR inhibitor INK128 promotes wound healing by regulating MDSCs
by: Yi Li, et al.
Published: (2021-03-01)

Obesity correlates with the immunosuppressive ILC2s‐MDSCs axis in advanced breast cancer
by: Wei Liu, et al.
Published: (2024-03-01)

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
by: Yeon Ji Park, et al.
Published: (2025-08-01)

Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer
by: Andrew M. K. Law, et al.
Published: (2020-02-01)

Myeloid-Derived Suppressor Cells in Bladder Cancer: An Emerging Target
by: Clément Klein, et al.
Published: (2024-10-01)

Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies
by: Boyuan Huang, et al.
Published: (2023-02-01)

Research Progress of Granulocytic Myeloid-derived Suppressor Cells  in Non-small Cell Lung Cancer
by: Chaodan YANG, et al.
Published: (2024-01-01)

MDSCs: Key Criminals of Tumor Pre-metastatic Niche Formation
by: Yungang Wang, et al.
Published: (2019-02-01)

Proliferation of MDSCs may indicate a lower CD4+ T cell immune response in schistosomiasis japonica
by: Peng Bo, et al.
Published: (2024-01-01)

Inhibiting CXCR4 reduces immunosuppressive effects of myeloid cells in breast cancer immunotherapy
by: Nicholas G. Ciavattone, et al.
Published: (2025-02-01)

KDM6A Lysine Demethylase Directs Epigenetic Polarity of MDSCs during Murine Sepsis
by: Isatou Bah, et al.
Published: (2021-07-01)

Drug-Loaded Mesoporous Silica Nanoparticles Enhance Antitumor Immunotherapy by Regulating MDSCs
by: Changlin Xu, et al.
Published: (2024-05-01)

Molecular mechanisms governing the differentiation and expansion of myeloid-derived suppressor cells
by: Ke Wang, et al.
Published: (2025-10-01)

Myeloid-Derived Suppressor Cells in Solid Tumors
by: Tianmiao Ma, et al.
Published: (2022-01-01)

S100A10 promotes cancer metastasis via recruitment of MDSCs within the lungs
by: Juan Li, et al.
Published: (2024-12-01)

Corrigendum: The Emerging Role of Myeloid-Derived Suppressor Cells in Tuberculosis
by: Tandeka Magcwebeba, et al.
Published: (2019-07-01)

Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling
by: Yifeng Zheng, et al.
Published: (2023-05-01)

Astaxanthin Treatment Induces Maturation and Functional Change of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice
by: Seong Mun Jeong, et al.
Published: (2020-04-01)

The Yin and Yang of Myeloid Derived Suppressor Cells
by: Snehil Budhwar, et al.
Published: (2018-11-01)

Immunosenescence: A Critical Factor Associated With Organ Injury After Sepsis
by: Xuan Lu, et al.
Published: (2022-07-01)