Ferroptosis in pain: evidence, challenges, and opportunities

Pain, an unpleasant but essential feeling for life, affects more than 20% of the global population and burdens health and the economy. Due to the lack of understanding of the exact fundamental mechanism, the existing therapeutic strategies for pain offer finite efficacy and troublesome side effects....

Full description

Bibliographic Details
Published in:	Frontiers in Immunology
Main Authors:	Qianqian Yan, Fang Wang, Mengyuan Liu, Jinyan Mao, Zihao Zhao, Bo Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-09-01
Subjects:	ferroptosis pain lipid peroxidation iron dyshomeostasis oxidative stress
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1673783/full

Similar Items

The Role Played by Ferroptosis in Osteoarthritis: Evidence Based on Iron Dyshomeostasis and Lipid Peroxidation
by: Shaoyun Zhang, et al.
Published: (2022-08-01)

The Emerging Roles of Ferroptosis in Vascular Cognitive Impairment
by: Nao Yan, et al.
Published: (2019-08-01)

Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis
by: Azhaar Ashraf, et al.
Published: (2020-05-01)

Molecular mechanisms of ferroptosis in Alzheimer's disease and breakthroughs in targeted therapeutics: translational advances from bench to bedside
by: WANG Younian, et al.
Published: (2025-06-01)

Mechanisms and regulations of ferroptosis
by: Xu-Dong Zhang, et al.
Published: (2023-10-01)

The mechanisms crosstalk and therapeutic opportunities between ferroptosis and ovary diseases
by: Ying Yao, et al.
Published: (2023-07-01)

The molecular mechanism of ferroptosis and its role in COPD
by: Dandan Meng, et al.
Published: (2023-01-01)

Ferroptosis as an emerging target in rheumatoid arthritis
by: Hui Zhao, et al.
Published: (2023-10-01)

Exerkines: Potential regulators of ferroptosis
by: Min Jia, et al.
Published: (2025-12-01)

HCMV infection downregulates GPX4 and stimulates lipid peroxidation but does not induce ferroptosis
by: Madison Martin, et al.
Published: (2025-02-01)

The Emerging Role of Ferroptosis in Sepsis, Opportunity or Challenge?
by: Huang Q, et al.
Published: (2023-08-01)

Ferroptosis and Its Emerging Role in Pre-Eclampsia
by: Zhixian Chen, et al.
Published: (2022-06-01)

The Multifaceted Regulation of Mitochondria in Ferroptosis
by: Hao Wu, et al.
Published: (2021-03-01)

Neurotoxicity of manganese via ferroptosis induced by redox imbalance and iron overload
by: Changyong Wang, et al.
Published: (2024-06-01)

Role of Ferroptosis in Non-Alcoholic Fatty Liver Disease and Its Implications for Therapeutic Strategies
by: Han Zhang, et al.
Published: (2021-11-01)

Mitochondrial ferroptosis in cardiovascular diseases: Mechanisms, biomarkers, and therapeutic opportunities — A narrative review
by: Siana Veedal Sequeira, et al.
Published: (2026-06-01)

Ferroptosis and Its Multifaceted Role in Cancer: Mechanisms and Therapeutic Approach
by: Heshu Chen, et al.
Published: (2022-07-01)

The role of ferroptosis in esophageal cancer
by: Zimin Wang, et al.
Published: (2022-08-01)

Ferroptosis: An Energetic Villain of Age-Related Macular Degeneration
by: Na Zhao, et al.
Published: (2025-04-01)

Targeting Ferroptosis in Rare Neurological Disorders Including Pediatric Conditions: Innovations and Therapeutic Challenges
by: Ahmed D. Alatawi, et al.
Published: (2025-01-01)

The Chains of Ferroptosis Interact in the Whole Progression of Atherosclerosis
by: Wan X, et al.
Published: (2023-10-01)

Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia
by: Hiroki Akiyama, et al.
Published: (2023-04-01)

Targeting ferroptosis: a novel insight into thyroid cancer therapy
by: Xinyao Liu, et al.
Published: (2025-06-01)

Ferroptosis in the tumor microenvironment: mechanisms, advances, and therapeutic perspectives
by: Weijuan Gao, et al.
Published: (2025-08-01)

The Mechanisms of Ferroptosis and the Applications in Tumor Treatment: Enemies or Friends?
by: Shuzheng Tan, et al.
Published: (2022-07-01)

Current understanding of ferroptosis in the progression and treatment of pancreatic cancer
by: Shi Dong, et al.
Published: (2021-09-01)

Pathological Characteristics of Ferroptosis in Kidney Tissues in Type 2 Diabetic Patients with Diabetic Kidney Disease
by: Li M, et al.
Published: (2024-11-01)

Ferroptosis in myocardial infarction: not a marker but a maker
by: Xiao-dong Wang, et al.
Published: (2021-04-01)

Ferroptosis in arterial atherosclerosis: mechanistic hypotheses, cell type specific vulnerabilities, translational biomarkers, and therapeutic opportunities
by: Cai Li, et al.
Published: (2026-06-01)

Ferroptosis: An emerging therapeutic opportunity for cancer
by: Liyuan Wang, et al.
Published: (2022-03-01)

Methionine alleviates heat stress-induced ferroptosis in bovine mammary epithelial cells through the Nrf2 pathway
by: Jie Xu, et al.
Published: (2023-05-01)

Role of ferroptosis in the pathogenesis of heart disease
by: Sulail Fatima, et al.
Published: (2024-09-01)

The Role of Ferroptosis in Nervous System Disorders
by: Lixia Du, et al.
Published: (2023-01-01)

The roles of sirtuins in ferroptosis
by: Jieqing Zeng, et al.
Published: (2023-04-01)

Targeting Ferroptosis Holds Potential for Intervertebral Disc Degeneration Therapy
by: Jiaxing Chen, et al.
Published: (2022-11-01)

Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular Disease
by: Lai-Hua Xie, et al.
Published: (2022-09-01)

Ferroptosis and Iron Metabolism after Intracerebral Hemorrhage
by: Yuanyuan Sun, et al.
Published: (2022-12-01)

Ferroptosis: Mechanism and potential applications in cervical cancer
by: Xiangyu Chang, et al.
Published: (2023-03-01)

Ferroptosis: key regulatory pathways and their implications in cardiovascular pathophysiology
by: Kaishen Cao, et al.
Published: (2026-04-01)

Recent progress in the effect of ferroptosis of HSCs on the development of liver fibrosis
by: Rui Tang, et al.
Published: (2023-09-01)