Cognate Ligand Chaperoning: a Novel Mechanism for the Post-translational Regulation of Neurotransmitter Receptor Biogenesis

The functional unit for inter-neuronal communication in the central nervous system is the neuronal synapse. The number of postsynaptic neurotransmitter receptors at the cell surface is an important determinant of synaptic efficacy and plasticity. A diverse array of post-translational processes regul...

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Bibliographic Details

Published in:	Frontiers in Cellular Neuroscience
Main Author:	Nancy J. Leidenheimer
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-08-01
Subjects:	cognate ligand chaperoning endoplasmic reticulum GABAA receptor glutamate receptor pharmacological chaperone
Online Access:	http://journal.frontiersin.org/article/10.3389/fncel.2017.00245/full